The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Itgb2l  -  integrin beta 2-like

Mus musculus

Synonyms: 5033406G21Rik, Integrin beta-2-like protein, Protein pactolus, pactolus
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Itgb2l

  • In addition, intracellular Pactolus translocates to the neutrophil surface following induction of apoptosis [1].
  • The increased expression of the membrane form of Pactolus by granulocytes of C57BL/6 mice suggests a compensatory adhesion function that is reduced in cells from the low producing strains [2].
  • One gene was identified that was preferentially expressed in the SCF-derived cells and encodes a novel murine integrin beta subunit-like molecule, dubbed Pactolus-1 (Pactolus) [3].
  • Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow [3].
  • Two distinct forms of Pactolus mRNA were detected which, via alternative splicing, are predicted to encode a membrane-bound form and truncated version of the protein [3].

Biological context of Itgb2l


Anatomical context of Itgb2l

  • These data suggest that Pactolus does not function as a neutrophil phagocytic or adhesion receptor, but may instead serve as a sugar-bearing ligand for lectin recognition by other cells [1].

Regulatory relationships of Itgb2l

  • Sequence analysis of the negative control region in the Pactolus promoter suggested potential control by Snail and/or Smad families of transcription regulators [5].
  • The numbers and expression patterns of these resident CXCL13-expressing cells do not vary in na??ve animals of wild type or Pactolus-deficient origin [6].

Other interactions of Itgb2l


Analytical, diagnostic and therapeutic context of Itgb2l


  1. Surface translocation of pactolus is induced by cell activation and death, but is not required for neutrophil migration and function. Garrison, S., Hojgaard, A., Margraf, R., Weis, J.J., Weis, J.H. J. Immunol. (2003) [Pubmed]
  2. Functional characterization of Pactolus, a beta-integrin-like protein preferentially expressed by neutrophils. Garrison, S., Hojgaard, A., Patillo, D., Weis, J.J., Weis, J.H. J. Biol. Chem. (2001) [Pubmed]
  3. Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow. Chen, Y., Garrison, S., Weis, J.J., Weis, J.H. J. Biol. Chem. (1998) [Pubmed]
  4. Genomic organization, chromosomal localization, and transcriptional variants of the murine Pactolus gene. Margraf, R.L., Chen, Y., Garrison, S., Weis, J.J., Weis, J.H. Mamm. Genome (1999) [Pubmed]
  5. Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). Hale, J.S., Dahlem, T.J., Margraf, R.L., Debnath, I., Weis, J.J., Weis, J.H. J. Leukoc. Biol. (2006) [Pubmed]
  6. Altered localization of CXCL13 expressing cells in mice deficient in Pactolus following an inflammatory stimulus. Hojgaard, A., Close, R., Dunn, D.M., Weiss, R.B., Weis, J.J., Weis, J.H. Immunology (2006) [Pubmed]
WikiGenes - Universities