The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Median Nerve

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Median Nerve

  • After experimental vibration of the forearm, plasma histamine levels in the ipsilateral antecubital vein rose in association with localized angioedema and slowed median nerve conduction velocity [1].
  • Maximum conduction velocity and relative refractory period (RRP) of median nerve sensory fibers were studied in 36 patients diagnosed as having multiple sclerosis (MS) and in 31 controls [2].
  • Excluding the carpal tunnel site from the analysis did not alter this observation: Mean DML were more prolonged in HNPP, even without median nerve data in the analysis (118.5%+/-31.0% of the upper limit of normal), than in CIDP (103.2%+/-31.6%; p<0.05) or diabetes (86.3%+/-18.3%; p<0.0001) [3].
  • In four cases in which symptoms persisted after surgery, findings valuable in explaining or predicting the failure included incomplete incision of the flexor retinaculum, excessive fat within the carpal tunnel, persistent neuritis of the median nerve, and development of neuromas [4].
  • This relative preservation of lumbrical motor fibres has been observed in other peripheral neuropathies and motor neuron disease, but not in median nerve regeneration of the following nerve transection [5].

Psychiatry related information on Median Nerve


High impact information on Median Nerve

  • 50 woke up at night due to paraesthesiae (with or without numbness or pain) in the fingers innervated by the median nerve (CTS symptoms) in 93 hands [7].
  • There was median-nerve neuropathy due to infiltration of the flexor retinaculum with amyloid in six patients [8].
  • We aimed at characterizing phase locking between SI and SII in response to electric stimuli applied once every 3 s to the right median nerve at the wrist; phase locking between brain regions has been proposed to either reflect joined processing or information exchange [9].
  • Inhibition of calcium-activated neutral protease, in muscle and nerve, by the tripeptide leupeptin after median nerve transection and epineural repair in monkeys (Cebus apella) was studied [10].
  • The btn mutation thus specifically eliminates the DM cells, and this genetic ablation in turn reveals a requirement for DM cells as cellular cues for axonal guidance during transverse nerve outgrowth and bifurcation of the median nerve [11].

Chemical compound and disease context of Median Nerve


Biological context of Median Nerve

  • Two subjects participated in two studies: (1) somatosensory (left and right median nerves were stimulated using a square wave pulse of 0.2 ms duration) and (2) visual (small black and white bull's-eye patterns were presented to central and peripheral locations in four quadrants of the visual field) [17].
  • The length of abnormal signal on T2-weighted images was significantly correlated with nerve conduction latency, and median nerve area was larger at the distal radioulnar joint (15.8 vs 11.8 mm(2)) in patients with CTS [18].
  • Early cortical median nerve somatosensory evoked potentials. Prognostic value in anoxic coma [19].
  • H reflexes were evoked in flexor muscles by stimulating the median nerve with single shocks at around motor threshold intensity [20].
  • In diabetic patients the degree of resistance to ischaemia correlated closely with HbAlc but not with the coincident blood glucose level, the duration of diabetes, the vibration perception threshold at the thumb or the initial median nerve action potential amplitude [21].

Anatomical context of Median Nerve

  • In an in vivo study, US was used to differentiate median nerve from flexor pollicis longus tendon in healthy volunteers (12 male and eight female subjects 7-68 years of age; mean age, 35 years) [22].
  • Distal motor conduction velocity from the posterior tibial nerve did not improve during the study (37.8 +/- 4.9 m/s v 36.4 +/- 4.9 m/s), while distal motor conduction velocity from the median nerve worsened (50.8 +/- 4.3 m/s v 46.3 +/- 6.3 m/s; P < 0.05) [23].
  • (8) Progressive changes were recorded within the original ulnar and radial nerve cortical representational zones, as skin surfaces originally overtly represented wholly within these regions expanded into the former median nerve zone [24].
  • We electrically stimulated the median nerve and recorded field potentials using a 12-channel depth probe in somatosensory cortex of ketamine anesthetized rats [25].
  • The symptoms in one case were partially relieved by ligation of the radial artery distal to the fistula, and in both they were abolished by decompression of the median nerve by section of the flexor retinaculum at the wrist [26].

Associations of Median Nerve with chemical compounds

  • There are two reasons for this: most upper compression mechanisms attach to the first rib, and the median nerve is also supplied by C8 and T1 as well as C5, C6, and C7 nerve roots [27].
  • Recognition of lumbrical sparing supports the electrodiagnosis of carpal tunnel syndrome when the distal latency to thenar muscles or the palm-to-wrist mixed median nerve conduction velocity is normal [28].
  • Repetitive stimulation of the median nerve showed a postsynaptic defect that was not corrected by edrophonium [29].
  • METHODS: We recorded pain-related SEPs after CO2 laser stimulation to the dorsum of the hand and electrically stimulated SEPs after median nerve stimulation at the wrist in 12 patients with stroke [30].
  • The N20 component of median nerve somatosensory evoked potentials-representing a biological marker of the location of central fissure-showed a phase reversal between electrodes P3 and C1 and thus was located considerably posterior to the spike maximum [31].

Gene context of Median Nerve


Analytical, diagnostic and therapeutic context of Median Nerve


  1. Occupationally acquired vibratory angioedema with secondary carpal tunnel syndrome. Wener, M.H., Metzger, W.J., Simon, R.A. Ann. Intern. Med. (1983) [Pubmed]
  2. Impaired refractory periods of peripheral sensory nerves in multiple sclerosis. Hopf, H.C., Eysholdt, M. Ann. Neurol. (1978) [Pubmed]
  3. Electrodiagnostic features of hereditary neuropathy with liability to pressure palsies. Andersson, P.B., Yuen, E., Parko, K., So, Y.T. Neurology (2000) [Pubmed]
  4. Carpal tunnel: MR imaging. Part II. Carpal tunnel syndrome. Mesgarzadeh, M., Schneck, C.D., Bonakdarpour, A., Mitra, A., Conaway, D. Radiology. (1989) [Pubmed]
  5. Relative preservation of lumbrical versus thenar motor fibres in neurogenic disorders. Yates, S.K., Yaworski, R., Brown, W.F. J. Neurol. Neurosurg. Psychiatr. (1981) [Pubmed]
  6. Abnormalities of parietal and prerolandic somatosensory evoked potentials in Huntington's disease. Abbruzzese, G., Dall'Agata, D., Morena, M., Reni, L., Favale, E. Electroencephalography and clinical neurophysiology. (1990) [Pubmed]
  7. Efficacy of provocative tests for diagnosis of carpal tunnel syndrome. de Krom, M.C., Knipschild, P.G., Kester, A.D., Spaans, F. Lancet (1990) [Pubmed]
  8. Neuropathy, M components, and amyloid. Benson, M.D., Cohen, A.S., Brandt, K.D., Cathcart, E.S. Lancet (1975) [Pubmed]
  9. Phase locking between human primary and secondary somatosensory cortices. Simões, C., Jensen, O., Parkkonen, L., Hari, R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Neuromuscular recovery using calcium protease inhibition after median nerve repair in primates. Badalamente, M.A., Hurst, L.C., Stracher, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Chiang, C., Patel, N.H., Young, K.E., Beachy, P.A. Development (1994) [Pubmed]
  12. Propofol narcosis dissociates human intrathalamic and cortical high-frequency (> 400 hz) SEP components. Klostermann, F., Funk, T., Vesper, J., Siedenberg, R., Curio, G. Neuroreport (2000) [Pubmed]
  13. Cortical arousal in critically ill patients: an evoked response study. Rundshagen, I., Schnabel, K., Pothmann, W., Schleich, B., Schulte am Esch, J. Intensive care medicine. (2000) [Pubmed]
  14. Effect of the acute administration of high dose pentobarbital on human brain stem auditory and median nerve somatosensory evoked responses. Drummond, J.C., Todd, M.M., Schubert, A., Sang, H. Neurosurgery (1987) [Pubmed]
  15. Effect of glycerol on ischemic edema evaluated by somatosensory evoked potentials. Suga, S., Sato, S., Ishihara, N., Togashi, O., Yunoki, K., Kobari, M. Advances in neurology. (1990) [Pubmed]
  16. Cubital nerve block vs haematoma block for the manipulation of Colles' fracture. Haasio, J. Annales chirurgiae et gynaecologiae. (1990) [Pubmed]
  17. Multistart algorithms for MEG empirical data analysis reliably characterize locations and time courses of multiple sources. Aine, C., Huang, M., Stephen, J., Christner, R. Neuroimage (2000) [Pubmed]
  18. MR nerve imaging in a prospective cohort of patients with suspected carpal tunnel syndrome. Jarvik, J.G., Yuen, E., Haynor, D.R., Bradley, C.M., Fulton-Kehoe, D., Smith-Weller, T., Wu, R., Kliot, M., Kraft, G., Wang, L., Erlich, V., Heagerty, P.J., Franklin, G.M. Neurology (2002) [Pubmed]
  19. Early cortical median nerve somatosensory evoked potentials. Prognostic value in anoxic coma. Walser, H., Mattle, H., Keller, H.M., Janzer, R. Arch. Neurol. (1985) [Pubmed]
  20. Reciprocal inhibition between the muscles of the human forearm. Day, B.L., Marsden, C.D., Obeso, J.A., Rothwell, J.C. J. Physiol. (Lond.) (1984) [Pubmed]
  21. The relationship between peripheral nerve resistance to ischaemia and diabetic control. Price, D.E., Alani, S.M., Carrington, A., Stickland, M.H., Wales, J.K. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  22. Echotexture of peripheral nerves: correlation between US and histologic findings and criteria to differentiate tendons. Silvestri, E., Martinoli, C., Derchi, L.E., Bertolotto, M., Chiaramondia, M., Rosenberg, I. Radiology. (1995) [Pubmed]
  23. Supplemented low-protein diet and once-weekly hemodialysis. Locatelli, F., Andrulli, S., Pontoriero, G., Di Filippo, S., Bigi, M.C. Am. J. Kidney Dis. (1994) [Pubmed]
  24. Progression of change following median nerve section in the cortical representation of the hand in areas 3b and 1 in adult owl and squirrel monkeys. Merzenich, M.M., Kaas, J.H., Wall, J.T., Sur, M., Nelson, R.J., Felleman, D.J. Neuroscience (1983) [Pubmed]
  25. Sequential activation of microcircuits underlying somatosensory-evoked potentials in rat neocortex. Jellema, T., Brunia, C.H., Wadman, W.J. Neuroscience (2004) [Pubmed]
  26. Carpal tunnel syndrome related to antebrachial Cimino-Brescia fistula. Harding, A.E., Le Fanu, J. J. Neurol. Neurosurg. Psychiatr. (1977) [Pubmed]
  27. Neurovascular compression in the thoracic outlet: changing management over 50 years. Urschel, H.C., Razzuk, M.A. Ann. Surg. (1998) [Pubmed]
  28. Lumbrical sparing in carpal tunnel syndrome: anatomic, physiologic, and diagnostic implications. Logigian, E.L., Busis, N.A., Berger, A.R., Bruyninckx, F., Khalil, N., Shahani, B.T., Young, R.R. Neurology (1987) [Pubmed]
  29. Neurologic complications of a coral snake bite. Pettigrew, L.C., Glass, J.P. Neurology (1985) [Pubmed]
  30. Pain-related and electrically stimulated somatosensory evoked potentials in patients with stroke. Yamamoto, M., Kachi, T., Igata, A. Stroke (1995) [Pubmed]
  31. Epileptic negative myoclonus: An EEG-single-photon emission CT study indicating involvement of premotor cortex. Baumgartner, C., Podreka, I., Olbrich, A., Novak, K., Serles, W., Aull, S., Almer, G., Lurger, S., Pietrzyk, U., Prayer, D., Lindinger, G. Neurology (1996) [Pubmed]
  32. Clinical, electrophysiological and molecular genetic characteristics of 93 patients with X-linked Charcot-Marie-Tooth disease. Dubourg, O., Tardieu, S., Birouk, N., Gouider, R., Léger, J.M., Maisonobe, T., Brice, A., Bouche, P., LeGuern, E. Brain (2001) [Pubmed]
  33. Median nerve motor conduction velocity is concordant with myelin protein zero gene mutation. Lee, Y.C., Soong, B.W., Liu, Y.T., Lin, K.P., Kao, K.P., Wu, Z.A. J. Neurol. (2005) [Pubmed]
  34. Intermediate nerve conduction velocities define X-linked Charcot-Marie-Tooth neuropathy families. Nicholson, G., Nash, J. Neurology (1993) [Pubmed]
  35. Changes in c-Fos protein expression in the rat cuneate nucleus after electric stimulation of the transected median nerve. Lue, J.H., Leong, S.M., Day, A.S., Tsai, Y.J., Shieh, J.Y., Wen, C.Y. J. Neurotrauma (2002) [Pubmed]
  36. Origin of the "N10" stationary-field potential after median nerve stimulation. Fujita, Y., Yamada, T., Inoue, K., Sato, A., Katayama, M., Ofuji, A., Fujita, H., Yeh, M. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1999) [Pubmed]
  37. Temporal dynamics of alpha and beta rhythms in human SI and SII after galvanic median nerve stimulation. A MEG study. Della Penna, S., Torquati, K., Pizzella, V., Babiloni, C., Franciotti, R., Rossini, P.M., Romani, G.L. Neuroimage (2004) [Pubmed]
  38. Timing and spatial distribution of somatosensory responses recorded in the upper bank of the sylvian fissure (SII area) in humans. Frot, M., Mauguière, F. Cereb. Cortex (1999) [Pubmed]
  39. The magnetic and electric fields agree with intracranial localizations of somatosensory cortex. Sutherling, W.W., Crandall, P.H., Darcey, T.M., Becker, D.P., Levesque, M.F., Barth, D.S. Neurology (1988) [Pubmed]
  40. Ultrasonography shows increased cross-sectional area of the median nerve in patients with arthritis and carpal tunnel syndrome. Hammer, H.B., Hovden, I.A., Haavardsholm, E.A., Kvien, T.K. Rheumatology (Oxford, England) (2006) [Pubmed]
  41. Validation of a surveillance case definition of carpal tunnel syndrome. Katz, J.N., Larson, M.G., Fossel, A.H., Liang, M.H. American journal of public health. (1991) [Pubmed]
WikiGenes - Universities