Disease relevance of Limbic Encephalitis

• Four were diagnosed as having influenza-associated encephalopathy, two nonherpetic limbic encephalitis, two theophylline-associated seizures, one Mycoplasma pneumoniae encephalitis, one acute encephalopathy, and one bacterial meningitis [1].
• fasciculations, autonomic symptoms and limbic encephalitis: a thymoma-associated Morvan's-like syndrome [2].
• Patient 1 showed paraneoplastic limbic encephalitis (PLE), paraneoplastic sensory neuropathy (PSN) and Lambert-Eaton myasthenic syndrome (LEMS) associated with SCLC [3].
• The experimental approach used could help to elucidate the role of autoantibodies in other paraneoplastic syndromes, such as SPS with antibodies to glutamic acid decarboxylase, and others including anti-Hu-associated subacute cerebellar degeneration and limbic encephalitis [4].

High impact information on Limbic Encephalitis

• Limbic encephalitis (LE) is often associated with lung, thymic, or testicular tumours and antibodies to Hu, CV2, or Ma2 (Ta) antigens [5].
• The authors report an autopsied patient with limbic encephalitis and recurrent thymoma [6].
• OBJECTIVE: To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm [7].
• No anti-BRSK2 antibodies were found in the serum of 50 patients with SCLC without PNS, 19 with limbic encephalitis without onconeural antibodies, 50 with anti-Hu antibodies and several paraneoplastic neurological syndromes, including 14 with limbic encephalitis, and 160 with a variety of non-paraneoplastic neurological syndromes [8].
• Our study suggests BRSK2 may be an autoantigen involved in the pathogenesis of SCLC-associated limbic encephalitis [8].

Chemical compound and disease context of Limbic Encephalitis

• BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis [8].
• A case of limbic encephalitis in a patient who had undergone prolonged immunosuppressive treatment with i.v. cyclophosphamide and oral prednisolone for a microscopic polyangeitis is reported [9].
• Steroid-responsive limbic encephalitis [10].

Biological context of Limbic Encephalitis

• A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library [11].

Anatomical context of Limbic Encephalitis

• Half of all patients with limbic encephalitis and small cell lung carcinoma (SCLC) have anti-Hu antibodies that react with all of central and peripheral nervous system neuronal nuclei in immunohistochemical studies and 35- to 40-kDa reactive bands on western blots of extracts from isolated central nervous system neurons [12].

Gene context of Limbic Encephalitis

• Limbic encephalitis: comparison of FDG PET and MR imaging findings [13].
• Paraneoplastic limbic encephalitis: diagnostic relevance of CSF analysis and total body PET scanning [14].

References