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Gene Review

Ltbp2  -  latent transforming growth factor beta...

Mus musculus

Synonyms: AW208642, LTBP-2, Latent-transforming growth factor beta-binding protein 2
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High impact information on Ltbp2


Biological context of Ltbp2

  • The 2 putative human homologues of mouse genes Ltbp2 and Spa-1 may be candidate tumor suppressor genes, but they map telomeric to D11S449 [2].
  • The Ltbp-1 gene contains 34 exons and shows a similar organization to the LTBP-2 gene, suggesting that these genes originated from a common ancestral gene [3].

Anatomical context of Ltbp2


Other interactions of Ltbp2

  • We report that the second and third TGF-bp repeats of LTBP-3 covalently bind the latent complex, and we show a similar capability for the homologous TGF-bp repeats of mouse LTBP-2 [5].
  • We studied the expression of LTBP-2 in the developing mouse and rat by in situ hybridization, using tropoelastin expression as a marker of tissues participating in elastic fiber formation [1].

Analytical, diagnostic and therapeutic context of Ltbp2


  1. Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. Shipley, J.M., Mecham, R.P., Maus, E., Bonadio, J., Rosenbloom, J., McCarthy, R.T., Baumann, M.L., Frankfater, C., Segade, F., Shapiro, S.D. Mol. Cell. Biol. (2000) [Pubmed]
  2. A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Sawicki, M., Arnold, E., Ebrahimi, S., Duell, T., Jin, S., Wood, T., Chakrabarti, R., Peters, J., Wan, Y., Samara, G., Weier, H.U., Udar, N., Passaro, E., Srivatsan, E.S. Genomics (1997) [Pubmed]
  3. Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Noguera, I., Obata, H., Gualandris, A., Cowin, P., Rifkin, D.B. Gene (2003) [Pubmed]
  4. Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression. Fang, J., Li, X., Smiley, E., Francke, U., Mecham, R.P., Bonadio, J. Biochim. Biophys. Acta (1997) [Pubmed]
  5. 8-Cysteine TGF-BP structural motifs are the site of covalent binding between mouse LTBP-3, LTBP-2, and latent TGF-beta 1. Yin, W., Fang, J., Smiley, E., Bonadio, J. Biochim. Biophys. Acta (1998) [Pubmed]
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