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Gene Review

Cygb  -  cytoglobin

Rattus norvegicus

Synonyms: Cytoglobin, HGb, Histoglobin, Staap, Stap, ...
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Disease relevance of Cygb

  • Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain [1].
  • By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis [2].

High impact information on Cygb


Biological context of Cygb


Associations of Cygb with chemical compounds


Other interactions of Cygb

  • Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin/STAP as liver fibrogenesis-related markers [7].

Analytical, diagnostic and therapeutic context of Cygb


  1. Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. Li, R.C., Lee, S.K., Pouranfar, F., Brittian, K.R., Clair, H.B., Row, B.W., Wang, Y., Gozal, D. Brain Res. (2006) [Pubmed]
  2. Cytoglobin overexpression protects against damage-induced fibrosis. Xu, R., Harrison, P.M., Chen, M., Li, L., Tsui, T.Y., Fung, P.C., Cheung, P.T., Wang, G., Li, H., Diao, Y., Krissansen, G.W., Xu, S., Farzaneh, F. Mol. Ther. (2006) [Pubmed]
  3. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. Kawada, N., Kristensen, D.B., Asahina, K., Nakatani, K., Minamiyama, Y., Seki, S., Yoshizato, K. J. Biol. Chem. (2001) [Pubmed]
  4. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Nakatani, K., Okuyama, H., Shimahara, Y., Saeki, S., Kim, D.H., Nakajima, Y., Seki, S., Kawada, N., Yoshizato, K. Lab. Invest. (2004) [Pubmed]
  5. Protection from ischemic cell death by the induction of cytoglobin. Stagner, J.I., Parthasarathy, S.N., Wyler, K., Parthasarathy, R.N. Transplant. Proc. (2005) [Pubmed]
  6. Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats. Kang, J.S., Wanibuchi, H., Morimura, K., Puatanachokchai, R., Salim, E.I., Hagihara, A., Seki, S., Fukushima, S. Toxicol. Sci. (2005) [Pubmed]
  7. Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin/STAP as liver fibrogenesis-related markers. Tateaki, Y., Ogawa, T., Kawada, N., Kohashi, T., Arihiro, K., Tateno, C., Obara, M., Yoshizato, K. Histochem. Cell Biol. (2004) [Pubmed]
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