The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cd180  -  CD180 antigen

Mus musculus

Synonyms: F630107B15, Ly-78, Ly78, Lymphocyte antigen 78, RP105, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Cd180


Biological context of Cd180


Anatomical context of Cd180

  • The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells [2].
  • These results demonstrate that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes [9].
  • RP105 ligation in vivo induced plasma cell differentiation [9].
  • RP105 expression was approximately 3-fold higher on marginal zone B cells than on follicular and B1 cells and was down-regulated on germinal center cells [9].
  • The expression of the human RP105 transcript was detected in some B cell lines, a histiocytic leukemia cell line, and peripheral blood leukocytes [7].

Associations of Cd180 with chemical compounds

  • Amino- and carboxyl-flanking regions that are characteristically conserved among members of the family are located on both sides of tandemly repeated leucine-rich motifs in RP105 molecule [5].
  • LPS induced tyrosine phosphorylation of CD19, which was RP105-dependent but TLR4-independent [10].


  1. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Divanovic, S., Trompette, A., Atabani, S.F., Madan, R., Golenbock, D.T., Visintin, A., Finberg, R.W., Tarakhovsky, A., Vogel, S.N., Belkaid, Y., Kurt-Jones, E.A., Karp, C.L. Nat. Immunol. (2005) [Pubmed]
  2. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. Ogata, H., Su, I., Miyake, K., Nagai, Y., Akashi, S., Mecklenbräuker, I., Rajewsky, K., Kimoto, M., Tarakhovsky, A. J. Exp. Med. (2000) [Pubmed]
  3. Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation. Yamashita, Y., Miyake, K., Miura, Y., Kaneko, Y., Yagita, H., Suda, T., Nagata, S., Nomura, J., Sakaguchi, N., Kimoto, M. J. Exp. Med. (1996) [Pubmed]
  4. Vav proteins are required for B-lymphocyte responses to LPS. Hebeis, B., Vigorito, E., Kovesdi, D., Turner, M. Blood (2005) [Pubmed]
  5. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. Miyake, K., Yamashita, Y., Ogata, M., Sudo, T., Kimoto, M. J. Immunol. (1995) [Pubmed]
  6. MD1 expression regulates development of regulatory T cells. Gorczynski, R.M., Kai, Y., Miyake, K. J. Immunol. (2006) [Pubmed]
  7. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). Miura, Y., Miyake, K., Yamashita, Y., Shimazu, R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Inazawa, J., Abe, T., Kimoto, M. Genomics (1996) [Pubmed]
  8. The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells. Hebeis, B.J., Vigorito, E., Turner, M. Biochem. Soc. Trans. (2004) [Pubmed]
  9. The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. Nagai, Y., Kobayashi, T., Motoi, Y., Ishiguro, K., Akashi, S., Saitoh, S., Kusumoto, Y., Kaisho, T., Akira, S., Matsumoto, M., Takatsu, K., Miyake, K. J. Immunol. (2005) [Pubmed]
  10. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Yazawa, N., Fujimoto, M., Sato, S., Miyake, K., Asano, N., Nagai, Y., Takeuchi, O., Takeda, K., Okochi, H., Akira, S., Tedder, T.F., Tamaki, K. Blood (2003) [Pubmed]
WikiGenes - Universities