High impact information on Cd180

• Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo [1].
• The analysis of mice homozygous for the null mutation in the RP105 gene revealed impaired proliferative and humoral immune responses of RP105-deficient B cells to LPS [2].
• On the other hand, CD40-activated B cells became extremely susceptible to Fas-mediated apoptosis, whereas RP105-activated B cells were much less sensitive [3].
• Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation [3].
• B lymphocytes respond to bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4) and CD180 (previously called RP105) [4].

Biological context of Cd180

• The RP105 molecule possesses 22 tandem repeats of a leucine-rich motif [5].
• Stable transfection of the cDNA clone conferred the expression of the RP105 Ag on a pro-B cell line, which was confirmed by immunofluorescence staining and immunoprecipitation with anti-RP105 mAb [5].
• We previously reported that MD1, a molecule known to be important in regulation of expression of RP105, also was important in regulating alloimmunity, and that blockade of expression of MD1 diminished graft rejection in vivo [6].
• The amino acid sequence of human RP105 is highly homologous to that of mouse RP105 with 74% identity, and the leucine-rich repeats are well conserved [7].
• In vitro, the proliferation and up-regulation of surface activation markers such as CD86 and CD25 induced by LPS and an antibody against RP105 were decreased [8].

Anatomical context of Cd180

• The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells [2].
• These results demonstrate that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes [9].
• RP105 ligation in vivo induced plasma cell differentiation [9].
• RP105 expression was approximately 3-fold higher on marginal zone B cells than on follicular and B1 cells and was down-regulated on germinal center cells [9].
• The expression of the human RP105 transcript was detected in some B cell lines, a histiocytic leukemia cell line, and peripheral blood leukocytes [7].

Associations of Cd180 with chemical compounds

• Amino- and carboxyl-flanking regions that are characteristically conserved among members of the family are located on both sides of tandemly repeated leucine-rich motifs in RP105 molecule [5].
• LPS induced tyrosine phosphorylation of CD19, which was RP105-dependent but TLR4-independent [10].

References