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Gene Review

Sstr3  -  somatostatin receptor 3

Rattus norvegicus

Synonyms: SS-3-R, SS3-R, SS3R, SSR-28, SSTR, ...
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High impact information on Sstr3

  • Here we report on the molecular and functional characterization of a somatostatin-28 receptor (SSR-28) cloned from a rat brain cDNA library [1].
  • Binding assays using radiolabeled somatostatin-14 and membranes from COS cells transfected with the cloned cDNA show that this receptor, SSR-28, has a higher binding affinity for somatostatin-28 (IC50 = 0.24 nM) than for somatostatin-14 (IC50 = 0.89 nM) [1].
  • In situ hybridization indicates that SSR-28 mRNA is present in the granular and Purkinje cell layers of the cerebellum and in the large cells of the hypoglossal nucleus of the brain stem [1].
  • Using specific anti-peptide antisera, we observed somatostatin receptor 3-like immunoreactivity in many brain regions, including the cerebral cortex, hippocampus, hypothalamus, amygdala and cerebellum [2].
  • Electron microscopic analysis revealed that somatostatin receptor 3-like immunoreactivity is localized to the plasma membrane of neuronal cilia which extended into an intercellular pocket and showed a 9+0 filament pattern in their basal body and proximal segments [2].

Anatomical context of Sstr3


Other interactions of Sstr3


  1. Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. Meyerhof, W., Wulfsen, I., Schönrock, C., Fehr, S., Richter, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Selective targeting of somatostatin receptor 3 to neuronal cilia. Händel, M., Schulz, S., Stanarius, A., Schreff, M., Erdtmann-Vourliotis, M., Schmidt, H., Wolf, G., Höllt, V. Neuroscience (1999) [Pubmed]
  3. Distribution of somatostatin receptors 1, 2 and 3 mRNA in rat brain and pituitary. Señarís, R.M., Humphrey, P.P., Emson, P.C. Eur. J. Neurosci. (1994) [Pubmed]
  4. Expression of somatostatin receptor 3 mRNA in the motorneurones of the rat spinal cord, and the sensory neurones of the spinal ganglia. Señaris, R.M., Schindler, M., Humphrey, P.P., Emson, P.C. Brain Res. Mol. Brain Res. (1995) [Pubmed]
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