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MeSH Review

Ganglia, Spinal

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Disease relevance of Ganglia, Spinal


High impact information on Ganglia, Spinal

  • In addition, Krox-20 is expressed in early neural crest cells, and then in the neural crest-derived boundary caps, glial components of the cranial and spinal ganglia [6].
  • We report here that NGF leads to an increase in SP in spinal ganglia, as previously shown by Kessler and Black. However, in contrast to these authors, we describe that the administration of anti-NGF antibodies produces a marked reduction of the SP content in sensory neurones and in their respective nerve terminals [7].
  • After infection, the presence of beta-galactosidase in neuronal cell bodies of the relevant spinal ganglia (lacZ-containing virus) and of human proenkephalin (preproenkephalin-encoding virus) in the central terminals of these neurons indicated appropriate gene delivery and expression [8].
  • Hox-1.11 poly(A)+ RNA also is expressed in the VII and VIII cranial ganglia, spinal cord, spinal ganglia, larynx, lungs, vertebrae, sternum, and intestine [9].
  • At 10.5 days p.c. and later, the pattern of beta-galactosidase activity diverges from the Hox-3.1 pattern, and an inappropriately high level of reporter gene expression is observed in posterior spinal ganglia [10].

Chemical compound and disease context of Ganglia, Spinal


Biological context of Ganglia, Spinal


Anatomical context of Ganglia, Spinal

  • Although striking patterns of expression of Hox 1.1 and other homeobox genes are seen in overtly segmented structures of the embryo (i.e. somites, prevertebral elements, neural tube and dorsal spinal ganglia) expression is also seen in tissues with no obvious segmental origin [18].
  • TGF-beta 1 mRNA was upregulated to high levels in sensory and motor roots, spinal ganglia, and sciatic nerve as revealed by quantitative Northern blot analysis and in situ hybridization histochemistry, with peak levels just preceding the first signs of clinical recovery [19].
  • Adrenal gland, spinal ganglia, skin, lung and--unexpectedly--ossification centers of developing mandible, clavicle and ribs were also positive at later stages (day 13.5-16.5 p.c.). From day 17.5 RON was expressed in the gut epithelium and in a specific area of the central nervous system, corresponding to the nucleus of the hypoglossus [20].
  • Amyloid deposits in leptomeningeal vessels, subarachnoid, subpial, and subependymal cerebrospinal regions, spinal ganglia, peripheral nerves, and some internal organs (predominantly heart and kidney) characterize a dominantly inherited disease in a Hungarian family [21].
  • Mice homozygous for Hoxb13 loss-of-function mutations show overgrowth in all major structures derived from the tail bud, including the developing secondary neural tube (SNT), the caudal spinal ganglia, and the caudal vertebrae [22].

Associations of Ganglia, Spinal with chemical compounds


Gene context of Ganglia, Spinal


Analytical, diagnostic and therapeutic context of Ganglia, Spinal


  1. Calcitonin gene-related peptide in the hepatic and splanchnic vascular systems of the rat. Sasaki, Y., Hayashi, N., Kasahara, A., Matsuda, H., Fusamoto, H., Sato, N., Hillyard, C.J., Girgis, S., MacIntyre, I., Emson, P.C. Hepatology (1986) [Pubmed]
  2. Ectopic midline spinal ganglion in diastematomyelia: a study of its connections. Ross, G.W., Swanson, S.A., Perentes, E., Urich, H. J. Neurol. Neurosurg. Psychiatr. (1988) [Pubmed]
  3. Autoradiographic localisation of 3H-uridine in spinal ganglion neurones of the rat and the effects of methyl mercury poisoning. Carmichael, N., Cavanagh, J.B. Acta Neuropathol. (1976) [Pubmed]
  4. The fine structure of granular endoplasmic reticulum in neurons and 14C-leucine incorporation into proteins in spinal ganglia of dog after ischemia. Orendácová, J., Chavko, M., Fercáková, A., Kluchová, D., Bona, M., Marsala, J. Neuropatologia polska. (1985) [Pubmed]
  5. Defective ensheathment of motoric nerves in the Splotch mutant mouse. Franz, T. Acta anatomica. (1990) [Pubmed]
  6. Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Wilkinson, D.G., Bhatt, S., Chavrier, P., Bravo, R., Charnay, P. Nature (1989) [Pubmed]
  7. Requirement of nerve growth factor for development of substance P-containing sensory neurones. Otten, U., Goedert, M., Mayer, N., Lembeck, F. Nature (1980) [Pubmed]
  8. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Wilson, S.P., Yeomans, D.C., Bender, M.A., Lu, Y., Goins, W.F., Glorioso, J.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Murine Hox-1.11 homeobox gene structure and expression. Tan, D.P., Ferrante, J., Nazarali, A., Shao, X., Kozak, C.A., Guo, V., Nirenberg, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. Evidence for positive and negative regulation of the Hox-3.1 gene. Bieberich, C.J., Utset, M.F., Awgulewitsch, A., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  11. Afferent fibers in the hypoglossal nerve: a horseradish peroxidase study in the cat. Takeuchi, Y., Hayakawa, T., Ozaki, H.S., Kito, J., Satoda, T., Matsushima, R. Brain Res. Bull. (1990) [Pubmed]
  12. 1,25(OH)2 vitamin D3 sites of action in spinal cord and sensory ganglion. Stumpf, W.E., Clark, S.A., O'Brien, L.P., Reid, F.A. Anat. Embryol. (1988) [Pubmed]
  13. Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. Antenos, M., Casper, R.F., Brown, T.J. J. Biol. Chem. (2002) [Pubmed]
  14. Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons. Shea, T.B., Yabe, J.T., Ortiz, D., Pimenta, A., Loomis, P., Goldman, R.D., Amin, N., Pant, H.C. J. Cell. Sci. (2004) [Pubmed]
  15. Localization of Apaf1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction. Müller, M., Berger, J., Gersdorff, N., Cecconi, F., Herken, R., Quondamatteo, F. Dev. Dyn. (2005) [Pubmed]
  16. Electrophysiology, acetylcholine and acetylcholinesterase of immature spinal ganglia of the rabbit--an experimental study and a review. Karczmar, A.G., Nishi, S., Minota, S., Kindel, G. Gen. Pharmacol. (1980) [Pubmed]
  17. On the influence of the perineuronal microenvironment on the outgrowth of perikaryal projections of spinal ganglion neurons. Pannese, E., Ledda, M., Conte, V., Rigamonti, L., Procacci, P. J. Submicrosc. Cytol. Pathol. (1995) [Pubmed]
  18. Expression of homeobox gene Hox 1.1 during mouse embryogenesis. Mahon, K.A., Westphal, H., Gruss, P. Development (1988) [Pubmed]
  19. Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course. Kiefer, R., Funa, K., Schweitzer, T., Jung, S., Bourde, O., Toyka, K.V., Hartung, H.P. Am. J. Pathol. (1996) [Pubmed]
  20. The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues. Gaudino, G., Avantaggiato, V., Follenzi, A., Acampora, D., Simeone, A., Comoglio, P.M. Oncogene (1995) [Pubmed]
  21. Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly). Garzuly, F., Vidal, R., Wisniewski, T., Brittig, F., Budka, H. Neurology (1996) [Pubmed]
  22. Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Economides, K.D., Zeltser, L., Capecchi, M.R. Dev. Biol. (2003) [Pubmed]
  23. An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site. Chambon, J.P., Feltz, P., Heaulme, M., Restle, S., Schlichter, R., Biziere, K., Wermuth, C.G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  24. Morphological and electrophysiological study of the effects of cisplatin and ORG.2766 on rat spinal ganglion neurons. Müller, L.J., Gerritsen van der Hoop, R., Moorer-van Delft, C.M., Gispen, W.H., Roubos, E.W. Cancer Res. (1990) [Pubmed]
  25. A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development. Knittel, T., Kessel, M., Kim, M.H., Gruss, P. Development (1995) [Pubmed]
  26. The neuronal endomembrane system. II. The multiple forms of the Golgi apparatus cis element. Lindsey, J.D., Ellisman, M.H. J. Neurosci. (1985) [Pubmed]
  27. Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study. Arbab, M.A., Delgado, T., Wiklund, L., Svendgaard, N.A. J. Cereb. Blood Flow Metab. (1988) [Pubmed]
  28. Fibroblast growth factor receptor 3 signaling regulates injury-related effects in the peripheral nervous system. Jungnickel, J., Gransalke, K., Timmer, M., Grothe, C. Mol. Cell. Neurosci. (2004) [Pubmed]
  29. Neural cell adhesion molecule expression in Xenopus embryos. Balak, K., Jacobson, M., Sunshine, J., Rutishauser, U. Dev. Biol. (1987) [Pubmed]
  30. In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia. Grothe, C., Meisinger, C., Claus, P. J. Comp. Neurol. (2001) [Pubmed]
  31. Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. van den Akker, E., Reijnen, M., Korving, J., Brouwer, A., Meijlink, F., Deschamps, J. Mech. Dev. (1999) [Pubmed]
  32. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 messenger RNAs in spinal ganglia and sciatic nerve: regulation after peripheral nerve lesion. Grothe, C., Meisinger, C., Hertenstein, A., Kurz, H., Wewetzer, K. Neuroscience (1997) [Pubmed]
  33. Membrane leakage in spinal ganglion nerve cells induced by experimental whiplash extension motion: a study in pigs. Ortengren, T., Hansson, H.A., Lövsund, P., Svensson, M.Y., Suneson, A., Säljö, A. J. Neurotrauma (1996) [Pubmed]
  34. Distribution of brain-derived neurotrophic factor in cranial and spinal ganglia. Zhou, X.F., Chie, E.T., Rush, R.A. Exp. Neurol. (1998) [Pubmed]
  35. Expression of somatostatin receptor 3 mRNA in the motorneurones of the rat spinal cord, and the sensory neurones of the spinal ganglia. Señaris, R.M., Schindler, M., Humphrey, P.P., Emson, P.C. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  36. Comparison between the early changes in isoniazid intoxication and the chromatolytic response to nerve ligation in spinal ganglion cells of the rat. Jones, H.B., Cavanagh, J.B. Neuropathol. Appl. Neurobiol. (1981) [Pubmed]
  37. Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Hökfelt, T., Kellerth, J.O., Nilsson, G., Pernow, B. Brain Res. (1975) [Pubmed]
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