The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IL17RD  -  interleukin 17 receptor D

Homo sapiens

Synonyms: FLJ35755, HH18, IL-17 receptor D, IL-17RD, IL17RLM, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL17RD

  • This putative receptor, which we have termed human SEF (hSEF), is also expressed in a variety of breast cancer tissues [1].
  • These results suggest evidence that hSef is downregulated in advanced prostate cancer and might facilitate an enhanced tumorigenic response to FGFs [2].
  • In contrast, metastasis was evident in only 10% (1/10) of tumours, which co-expressed both FGF8 and hSef (P<0.001) [2].

High impact information on IL17RD

  • Our results demonstrated that stably expressed hSef strongly inhibits FGF2- or nerve growth factor-induced PC-12 cell differentiation [3].
  • Based on sequence and functional similarities, this novel IL-17 receptor homologue represents a potential human SEF and is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis [1].
  • hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling [3] .

Biological context of IL17RD


Anatomical context of IL17RD


Associations of IL17RD with chemical compounds

  • Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling [6] .

Regulatory relationships of IL17RD

  • Reduced hSef levels also enhanced FGF8b stimulated expression of MMP9 (P=0.005). mRNA in situ hybridization revealed hSef expression in 80% (8/10) of benign biopsies but in only 69% (23/33) of Gleason sum 4-7 and 35% (10/28) of Gleason sum 8-10 cancer biopsies (P=0.004) [2].

Other interactions of IL17RD

  • The intracellular domain of hSef is necessary for the inhibitory effect on FGF2-induced PC-12 cell differentiation [3].
  • These results thus demonstrate that hSef acts as a spatial regulator for ERK signaling by targeting ERK to the cytoplasm [4].
  • The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE [7].

Analytical, diagnostic and therapeutic context of IL17RD

  • Quantitative PCR of microdissected glands confirmed this trend (P=0.001). hSef was expressed in 69% (27/39) of non-metastatic tumours but in only 18% (2/11) of metastatic tumours (P=0.004, n=50). hSef expression was next correlated with earlier data on FGF8b expression in a subgroup of cancers [2].


  1. A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. Yang, R.B., Ng, C.K., Wasserman, S.M., Kömüves, L.G., Gerritsen, M.E., Topper, J.N. J. Biol. Chem. (2003) [Pubmed]
  2. Loss of Sef (similar expression to FGF) expression is associated with high grade and metastatic prostate cancer. Darby, S., Sahadevan, K., Khan, M.M., Robson, C.N., Leung, H.Y., Gnanapragasam, V.J. Oncogene (2006) [Pubmed]
  3. hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. Xiong, S., Zhao, Q., Rong, Z., Huang, G., Huang, Y., Chen, P., Zhang, S., Liu, L., Chang, Z. J. Biol. Chem. (2003) [Pubmed]
  4. Sef is a spatial regulator for Ras/MAP kinase signaling. Torii, S., Kusakabe, M., Yamamoto, T., Maekawa, M., Nishida, E. Dev. Cell (2004) [Pubmed]
  5. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. Haudenschild, D.R., Curtiss, S.B., Moseley, T.A., Reddi, A.H. Prostate (2006) [Pubmed]
  6. Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling. Ren, Y., Li, Z., Rong, Z., Cheng, L., Li, Y., Wang, Z., Chang, Z. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  7. Interleukin-17 family and IL-17 receptors. Moseley, T.A., Haudenschild, D.R., Rose, L., Reddi, A.H. Cytokine Growth Factor Rev. (2003) [Pubmed]
WikiGenes - Universities