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Gene Review

pept-2  -  Protein PEPT-2

Caenorhabditis elegans

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High impact information on opt-1

  • Electrophysiological studies of the transport function of OPT3 in Xenopus oocytes show that this transporter, although capable of mediating H(+)-coupled peptide transport, functions predominantly as a H(+) channel [1].
  • The opt3 gene is approximately 4.4 kilobases long and consists of 13 exons [1].
  • OPT3 may play an important physiological role as a pH balancer in the maintenance of H(+) homeostasis in C. elegans [1].
  • Two novel oligopeptide transporter cDNA clones, CPTA and CPTB, were identified by screening a Caenorhabditis elegans cDNA library using homology hybridization [2].
  • Upstream sequences of the Haemonchus contortus gut pepsinogen gene pep-1 and cysteine protease gene AC-2 direct expression exclusively in gut cells, while promoter sequence of the Ostertagia circumcincta cuticular collagen gene colost-1 directs hypodermal-specific expression [3].

Associations of opt-1 with chemical compounds


Analytical, diagnostic and therapeutic context of opt-1

  • The H(+) channel activity of OPT3 is approximately 3-4-fold greater than the H(+)/peptide cotransport activity as determined by measurements of H(+) gradient-induced inward currents in the absence and presence of the dipeptide using the two-microelectrode voltage clamp technique [1].


  1. A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons. Fei, Y.J., Romero, M.F., Krause, M., Liu, J.C., Huang, W., Ganapathy, V., Leibach, F.H. J. Biol. Chem. (2000) [Pubmed]
  2. Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression. Fei, Y.J., Fujita, T., Lapp, D.F., Ganapathy, V., Leibach, F.H. Biochem. J. (1998) [Pubmed]
  3. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Britton, C., Redmond, D.L., Knox, D.P., McKerrow, J.H., Barry, J.D. Mol. Biochem. Parasitol. (1999) [Pubmed]
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