The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Nid2  -  nidogen 2

Mus musculus

Synonyms: AW547149, Entactin-2, Ly111, NID-2, Nidogen-2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nid2

 

High impact information on Nid2

 

Biological context of Nid2

 

Anatomical context of Nid2

 

Associations of Nid2 with chemical compounds

  • The rod-like domain of entactin-2, containing the RGD integrin recognition sequence, fused to glutathione-S transferase (GST), revealed a cell surface-binding activity similar to that of entactin [5].
  • Furthermore, treatment with the translation inhibitor cycloheximide could show that entactin-2 is a primary response gene [7].
 

Other interactions of Nid2

 

Analytical, diagnostic and therapeutic context of Nid2

  • We have now localized nidogen-1 and nidogen-2, as well as their corresponding mRNAs, at the light and electron microscopic levels in adult mouse kidney, by in situ hybridization and immunogold histochemistry, as well as carrying out double labeling with laminin-1 [9].
  • Furthermore, decreased expression of the entactin-2 gene after treatment of the cells with ent-2-specific siRNA preparation led to reduced expression of the cell cycle inhibitor p21 [7].

References

  1. Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Schymeinsky, J., Nedbal, S., Miosge, N., Pöschl, E., Rao, C., Beier, D.R., Skarnes, W.C., Timpl, R., Bader, B.L. Mol. Cell. Biol. (2002) [Pubmed]
  2. Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. Talts, J.F., Andac, Z., Göhring, W., Brancaccio, A., Timpl, R. EMBO J. (1999) [Pubmed]
  3. The absence of nidogen 1 does not affect murine basement membrane formation. Murshed, M., Smyth, N., Miosge, N., Karolat, J., Krieg, T., Paulsson, M., Nischt, R. Mol. Cell. Biol. (2000) [Pubmed]
  4. Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens. Salmivirta, K., Talts, J.F., Olsson, M., Sasaki, T., Timpl, R., Ekblom, P. Exp. Cell Res. (2002) [Pubmed]
  5. Entactin-2: a new member of basement membrane protein with high homology to entactin/nidogen. Kimura, N., Toyoshima, T., Kojima, T., Shimane, M. Exp. Cell Res. (1998) [Pubmed]
  6. Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. Miosge, N., Sasaki, T., Timpl, R. Matrix Biol. (2002) [Pubmed]
  7. Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation. Neu, R., Adams, S., Munz, B. Differentiation (2006) [Pubmed]
  8. Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development. Miosge, N., Holzhausen, S., Zelent, C., Sprysch, P., Herken, R. Histochem. J. (2001) [Pubmed]
  9. Ultrastructural colocalization of nidogen-1 and nidogen-2 with laminin-1 in murine kidney basement membranes. Miosge, N., Köther, F., Heinemann, S., Kohfeldt, E., Herken, R., Timpl, R. Histochem. Cell Biol. (2000) [Pubmed]
  10. Hematopoietic Cells Are a Source of Nidogen-1 and Nidogen-2 during Mouse Liver Development. Tomte, L.T., Annatshah, Y., Schlüter, N.K., Miosge, N., Herken, R., Quondamatteo, F. J. Histochem. Cytochem. (2006) [Pubmed]
  11. Basement membrane composition in the early mouse embryo day 7. Gersdorff, N., Müller, M., Otto, S., Poschadel, R., Hübner, S., Miosge, N. Dev. Dyn. (2005) [Pubmed]
 
WikiGenes - Universities