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Gene Review

Nid2  -  nidogen 2

Mus musculus

Synonyms: AW547149, Entactin-2, Ly111, NID-2, Nidogen-2, ...
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Disease relevance of Nid2


High impact information on Nid2


Biological context of Nid2


Anatomical context of Nid2


Associations of Nid2 with chemical compounds

  • The rod-like domain of entactin-2, containing the RGD integrin recognition sequence, fused to glutathione-S transferase (GST), revealed a cell surface-binding activity similar to that of entactin [5].
  • Furthermore, treatment with the translation inhibitor cycloheximide could show that entactin-2 is a primary response gene [7].

Other interactions of Nid2


Analytical, diagnostic and therapeutic context of Nid2

  • We have now localized nidogen-1 and nidogen-2, as well as their corresponding mRNAs, at the light and electron microscopic levels in adult mouse kidney, by in situ hybridization and immunogold histochemistry, as well as carrying out double labeling with laminin-1 [9].
  • Furthermore, decreased expression of the entactin-2 gene after treatment of the cells with ent-2-specific siRNA preparation led to reduced expression of the cell cycle inhibitor p21 [7].


  1. Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Schymeinsky, J., Nedbal, S., Miosge, N., Pöschl, E., Rao, C., Beier, D.R., Skarnes, W.C., Timpl, R., Bader, B.L. Mol. Cell. Biol. (2002) [Pubmed]
  2. Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. Talts, J.F., Andac, Z., Göhring, W., Brancaccio, A., Timpl, R. EMBO J. (1999) [Pubmed]
  3. The absence of nidogen 1 does not affect murine basement membrane formation. Murshed, M., Smyth, N., Miosge, N., Karolat, J., Krieg, T., Paulsson, M., Nischt, R. Mol. Cell. Biol. (2000) [Pubmed]
  4. Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens. Salmivirta, K., Talts, J.F., Olsson, M., Sasaki, T., Timpl, R., Ekblom, P. Exp. Cell Res. (2002) [Pubmed]
  5. Entactin-2: a new member of basement membrane protein with high homology to entactin/nidogen. Kimura, N., Toyoshima, T., Kojima, T., Shimane, M. Exp. Cell Res. (1998) [Pubmed]
  6. Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. Miosge, N., Sasaki, T., Timpl, R. Matrix Biol. (2002) [Pubmed]
  7. Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation. Neu, R., Adams, S., Munz, B. Differentiation (2006) [Pubmed]
  8. Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development. Miosge, N., Holzhausen, S., Zelent, C., Sprysch, P., Herken, R. Histochem. J. (2001) [Pubmed]
  9. Ultrastructural colocalization of nidogen-1 and nidogen-2 with laminin-1 in murine kidney basement membranes. Miosge, N., Köther, F., Heinemann, S., Kohfeldt, E., Herken, R., Timpl, R. Histochem. Cell Biol. (2000) [Pubmed]
  10. Hematopoietic Cells Are a Source of Nidogen-1 and Nidogen-2 during Mouse Liver Development. Tomte, L.T., Annatshah, Y., Schlüter, N.K., Miosge, N., Herken, R., Quondamatteo, F. J. Histochem. Cytochem. (2006) [Pubmed]
  11. Basement membrane composition in the early mouse embryo day 7. Gersdorff, N., Müller, M., Otto, S., Poschadel, R., Hübner, S., Miosge, N. Dev. Dyn. (2005) [Pubmed]
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