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Gene Review

Fbln2  -  fibulin 2

Mus musculus

Synonyms: 5730577E14Rik, FIBL-2, Fibulin-2
 
 
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Disease relevance of Fbln2

  • In this study, we cloned the extreme 5' end of the mouse fibulin-2 cDNA, isolated phage and cosmid clones encoding the entire gene, and functionally characterized the promoter [1].
 

High impact information on Fbln2

 

Biological context of Fbln2

 

Anatomical context of Fbln2

 

Associations of Fbln2 with chemical compounds

  • Synthetic SVPRGDLDG peptide, corresponding to the single RGD site of mouse fibulin-2, was a strong antagonist of alpha IIb beta 3 integrin binding [9].
  • Dexamethasone treatment led to a decreased expression of tenascin-C in healing wounds but had no effect on fibulin-2 expression [10].
  • Metabolic labelling and pulse-chase studies demonstrated fibulin-2 oligomers in detergent extracts of cells and their rapid translocation to extracellular EDTA-sensitive assembly forms [11].
  • Most of the fibroblast fibulin-2 is deposited into a dense fibrillar meshwork which requires treatment with EDTA and/or 6 M urea for solubilization [11].
 

Other interactions of Fbln2

 

Analytical, diagnostic and therapeutic context of Fbln2

References

  1. Mouse fibulin-2 gene. Complete exon-intron organization and promoter characterization. Grässel, S., Sicot, F.X., Gotta, S., Chu, M.L. Eur. J. Biochem. (1999) [Pubmed]
  2. Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. Talts, J.F., Andac, Z., Göhring, W., Brancaccio, A., Timpl, R. EMBO J. (1999) [Pubmed]
  3. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. Sasaki, T., Fukai, N., Mann, K., Göhring, W., Olsen, B.R., Timpl, R. EMBO J. (1998) [Pubmed]
  4. Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge. Sasaki, T., Mann, K., Wiedemann, H., Göhring, W., Lustig, A., Engel, J., Chu, M.L., Timpl, R. EMBO J. (1997) [Pubmed]
  5. Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. Pan, T.C., Sasaki, T., Zhang, R.Z., Fässler, R., Timpl, R., Chu, M.L. J. Cell Biol. (1993) [Pubmed]
  6. Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo. Zhang, H.Y., Timpl, R., Sasaki, T., Chu, M.L., Ekblom, P. Dev. Dyn. (1996) [Pubmed]
  7. Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. Lemaire, R., Korn, J.H., Schiemann, W.P., Lafyatis, R. J. Invest. Dermatol. (2004) [Pubmed]
  8. Different susceptibilities of fibulin-1 and fibulin-2 to cleavage by matrix metalloproteinases and other tissue proteases. Sasaki, T., Mann, K., Murphy, G., Chu, M.L., Timpl, R. Eur. J. Biochem. (1996) [Pubmed]
  9. Integrin-binding and cell-adhesion studies of fibulins reveal a particular affinity for alpha IIb beta 3. Pfaff, M., Sasaki, T., Tangemann, K., Chu, M.L., Timpl, R. Exp. Cell Res. (1995) [Pubmed]
  10. Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice. Fässler, R., Sasaki, T., Timpl, R., Chu, M.L., Werner, S. Exp. Cell Res. (1996) [Pubmed]
  11. Expression of fibulin-2 by fibroblasts and deposition with fibronectin into a fibrillar matrix. Sasaki, T., Wiedemann, H., Matzner, M., Chu, M.L., Timpl, R. J. Cell. Sci. (1996) [Pubmed]
  12. Skin wounds and severed nerves heal normally in mice lacking tenascin-C. Forsberg, E., Hirsch, E., Fröhlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S., Fässler, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Ström, A., Olin, A.I., Aspberg, A., Hultgårdh-Nilsson, A. Cardiovasc. Res. (2006) [Pubmed]
 
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