The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ugt-8  -  Protein UGT-8

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ugt-8


High impact information on ugt-8


Biological context of ugt-8


Associations of ugt-8 with chemical compounds

  • Possible functional roles of the adult E/S products were examined but we could find no evidence of protease activity in the E/S or glutathione S-transferase activity in either the E/S or in whole somatic extract [10].
  • This article is an attempt to provide, in an easily accessible format, a compilation of genes and cDNAs that have been sequenced and deposited in GenBank that encode transferase enzymes involved in eukaryotic glycoprotein or glycolipid biosynthesis [11].
  • A soluble GSH transferase of the parasitic nematode Ascaridia galli has now been purified which shows high activity and specificity in the GSH-dependent isomerization of PGH to PGE, comparable to that of the rat spleen enzyme in its isomerization of PGH to PGD, and similarly stimulates the activity of prostaglandin H synthase [12].
  • The bromodomain can regulate histone acetyl transferase activity and interacts specifically with acetylated lysine residues [13].
  • The trematode and cestode exhibit propionyl-CoA carboxylase, methylmalonyl-CoA mutase and acyl-CoA transferase activities in sonicated mitochondrial preparations [14].

Other interactions of ugt-8


  1. A Phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. Ciche, T.A., Bintrim, S.B., Horswill, A.R., Ensign, J.C. J. Bacteriol. (2001) [Pubmed]
  2. Resistance of filarial nematode parasites to oxidative stress. Selkirk, M.E., Smith, V.P., Thomas, G.R., Gounaris, K. Int. J. Parasitol. (1998) [Pubmed]
  3. Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase. Burda, P., te Heesen, S., Brachat, A., Wach, A., Düsterhöft, A., Aebi, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis. Abdelghany, H.M., Bailey, S., Blackburn, G.M., Rafferty, J.B., McLennan, A.G. J. Biol. Chem. (2003) [Pubmed]
  5. Identification, characterization, and crystal structure of the Omega class glutathione transferases. Board, P.G., Coggan, M., Chelvanayagam, G., Easteal, S., Jermiin, L.S., Schulte, G.K., Danley, D.E., Hoth, L.R., Griffor, M.C., Kamath, A.V., Rosner, M.H., Chrunyk, B.A., Perregaux, D.E., Gabel, C.A., Geoghegan, K.F., Pandit, J. J. Biol. Chem. (2000) [Pubmed]
  6. Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. Benachour, A., Sipos, G., Flury, I., Reggiori, F., Canivenc-Gansel, E., Vionnet, C., Conzelmann, A., Benghezal, M. J. Biol. Chem. (1999) [Pubmed]
  7. O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. Lubas, W.A., Frank, D.W., Krause, M., Hanover, J.A. J. Biol. Chem. (1997) [Pubmed]
  8. Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia. Veronico, P., Gray, L.J., Jones, J.T., Bazzicalupo, P., Arbucci, S., Cortese, M.R., Di Vito, M., De Giorgi, C. Mol. Genet. Genomics (2001) [Pubmed]
  9. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Lackner, M.R., Kindt, R.M., Carroll, P.M., Brown, K., Cancilla, M.R., Chen, C., de Silva, H., Franke, Y., Guan, B., Heuer, T., Hung, T., Keegan, K., Lee, J.M., Manne, V., O'Brien, C., Parry, D., Perez-Villar, J.J., Reddy, R.K., Xiao, H., Zhan, H., Cockett, M., Plowman, G., Fitzgerald, K., Costa, M., Ross-Macdonald, P. Cancer Cell (2005) [Pubmed]
  10. Secreted antigens of filarial nematodes: a survey and characterization of in vitro excreted/secreted products of adult Brugia malayi. Kwan-Lim, G.E., Gregory, W.F., Selkirk, M.E., Partono, F., Maizels, R.M. Parasite Immunol. (1989) [Pubmed]
  11. Molecular cloning of eukaryotic glycoprotein and glycolipid glycosyltransferases: a survey. Field, M.C., Wainwright, L.J. Glycobiology (1995) [Pubmed]
  12. Purification and characterization of prostaglandin-H E-isomerase, a sigma-class glutathione S-transferase, from Ascaridia galli. Meyer, D.J., Muimo, R., Thomas, M., Coates, D., Isaac, R.E. Biochem. J. (1996) [Pubmed]
  13. Identification and characterization of BPTF, a novel bromodomain transcription factor. Jones, M.H., Hamana, N., Shimane, M. Genomics (2000) [Pubmed]
  14. Succinate decarboxylation to propionate and the associated phosphorylation in Fasciola hepatica and Spirometra mansonoides. Pietrzak, S.M., Saz, H.J. Mol. Biochem. Parasitol. (1981) [Pubmed]
  15. Phase I and phase II enzymes produced by Cunninghamella elegans for the metabolism of xenobiotics. Zhang, D., Yang, Y., Leakey, J.E., Cerniglia, C.E. FEMS Microbiol. Lett. (1996) [Pubmed]
WikiGenes - Universities