Gene Review:
E2F3 - E2F transcription factor 3
Homo sapiens
Synonyms:
E2F-3, KIAA0075, Transcription factor E2F3
- Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Foster, C.S., Falconer, A., Dodson, A.R., Norman, A.R., Dennis, N., Fletcher, A., Southgate, C., Dowe, A., Dearnaley, D., Jhavar, S., Eeles, R., Feber, A., Cooper, C.S. Oncogene (2004)
- Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Grasemann, C., Gratias, S., Stephan, H., Schüler, A., Schramm, A., Klein-Hitpass, L., Rieder, H., Schneider, S., Kappes, F., Eggert, A., Lohmann, D.R. Oncogene (2005)
- Nuclear overexpression of the E2F3 transcription factor in human lung cancer. Cooper, C.S., Nicholson, A.G., Foster, C., Dodson, A., Edwards, S., Fletcher, A., Roe, T., Clark, J., Joshi, A., Norman, A., Feber, A., Lin, D., Gao, Y., Shipley, J., Cheng, S.J. Lung Cancer (2006)
- E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Leone, G., DeGregori, J., Yan, Z., Jakoi, L., Ishida, S., Williams, R.S., Nevins, J.R. Genes Dev. (1998)
- The retinoblastoma protein binds to a family of E2F transcription factors. Lees, J.A., Saito, M., Vidal, M., Valentine, M., Look, T., Harlow, E., Dyson, N., Helin, K. Mol. Cell. Biol. (1993)
- Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Adams, M.R., Sears, R., Nuckolls, F., Leone, G., Nevins, J.R. Mol. Cell. Biol. (2000)
- Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Sears, R., Ohtani, K., Nevins, J.R. Mol. Cell. Biol. (1997)
- Direct Regulation of an Oncogenic Micro-RNA Cluster by E2F Transcription Factors. Woods, K., Thomson, J.M., Hammond, S.M. J. Biol. Chem. (2007)
- A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. Wang, B., Liu, K., Lin, F.T., Lin, W.C. J. Biol. Chem. (2004)
- Regulation of the G1/S transition phase in mesangial cells by E2F1. Inoshita, S., Terada, Y., Nakashima, O., Kuwahara, M., Sasaki, S., Marumo, F. Kidney Int. (1999)
- Differentiation and injury-repair signals modulate the interaction of E2F and pRB proteins with novel target genes in keratinocytes. Chang, W.Y., Andrews, J., Carter, D.E., Dagnino, L. Cell Cycle (2006)
- E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer. Oeggerli, M., Schraml, P., Ruiz, C., Bloch, M., Novotny, H., Mirlacher, M., Sauter, G., Simon, R. Oncogene (2006)
- E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation. Strom, D.K., Cleveland, J.L., Chellappan, S., Nip, J., Hiebert, S.W. Cell Growth Differ. (1998)
- Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention. Tyagi, A., Agarwal, C., Agarwal, R. Mol. Cancer Ther. (2002)
- Compensation and specificity of function within the E2F family. Kong, L.J., Chang, J.T., Bild, A.H., Nevins, J.R. Oncogene (2007)
- BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. Zhou, J., Ma, J., Zhang, B.C., Li, X.L., Shen, S.R., Zhu, S.G., Xiong, W., Liu, H.Y., Huang, H., Zhou, M., Li, G.Y. J. Cell. Physiol. (2004)
- E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Moberg, K., Starz, M.A., Lees, J.A. Mol. Cell. Biol. (1996)
- Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors. Veltman, J.A., Fridlyand, J., Pejavar, S., Olshen, A.B., Korkola, J.E., DeVries, S., Carroll, P., Kuo, W.L., Pinkel, D., Albertson, D., Cordon-Cardo, C., Jain, A.N., Waldman, F.M. Cancer Res. (2003)
- Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1. Xie, W., Jiang, P., Miao, L., Zhao, Y., Zhimin, Z., Qing, L., Zhu, W.G., Wu, M. Nucleic Acids Res. (2006)
- Heterogeneous Cross-talk of E2F Family Members is Crucially Involved in Growth Modulatory Effects of Interferon-gamma and EGF. Reimer, D., Sadr, S., Wiedemair, A., Concin, N., Hofstetter, G., Marth, C., Zeimet, A.G. Cancer Biol. Ther. (2006)
- E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Oeggerli, M., Tomovska, S., Schraml, P., Calvano-Forte, D., Schafroth, S., Simon, R., Gasser, T., Mihatsch, M.J., Sauter, G. Oncogene (2004)