Gene Review:
E2f3 - E2F transcription factor 3
Mus musculus
Synonyms:
E2F-3, E2F3b, E2f3a, Transcription factor E2F3
- E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Ziebold, U., Lee, E.Y., Bronson, R.T., Lees, J.A. Mol. Cell. Biol. (2003)
- Expression patterns of the E2F family of transcription factors during mouse nervous system development. Dagnino, L., Fry, C.J., Bartley, S.M., Farnham, P., Gallie, B.L., Phillips, R.A. Mech. Dev. (1997)
- Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. Ebelt, H., Hufnagel, N., Neuhaus, P., Neuhaus, H., Gajawada, P., Simm, A., Müller-Werdan, U., Werdan, K., Braun, T. Circ. Res. (2005)
- Rb is critical in a mammalian tissue stem cell population. Wenzel, P.L., Wu, L., de Bruin, A., Chong, J.L., Chen, W.Y., Dureska, G., Sites, E., Pan, T., Sharma, A., Huang, K., Ridgway, R., Mosaliganti, K., Sharp, R., Machiraju, R., Saltz, J., Yamamoto, H., Cross, J.C., Robinson, M.L., Leone, G. Genes Dev. (2007)
- Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Aslanian, A., Iaquinta, P.J., Verona, R., Lees, J.A. Genes Dev. (2004)
- E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Ziebold, U., Reza, T., Caron, A., Lees, J.A. Genes Dev. (2001)
- E2f3 is critical for normal cellular proliferation. Humbert, P.O., Verona, R., Trimarchi, J.M., Rogers, C., Dandapani, S., Lees, J.A. Genes Dev. (2000)
- Distinctions in the specificity of E2F function revealed by gene expression signatures. Black, E.P., Hallstrom, T., Dressman, H.K., West, M., Nevins, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Leone, G., Nuckolls, F., Ishida, S., Adams, M., Sears, R., Jakoi, L., Miron, A., Nevins, J.R. Mol. Cell. Biol. (2000)
- Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 Is Essential for G1/S Progression and Cellular Transformation. Sharma, N., Timmers, C., Trikha, P., Saavedra, H.I., Obery, A., Leone, G. J. Biol. Chem. (2006)
- Multiple members of the E2F transcription factor family are the products of oncogenes. Xu, G., Livingston, D.M., Krek, W. Proc. Natl. Acad. Sci. U.S.A. (1995)
- The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. Chang, W.Y., Bryce, D.M., D'Souza, S.J., Dagnino, L. J. Biol. Chem. (2004)
- Inactivation of E2F3 results in centrosome amplification. Saavedra, H.I., Maiti, B., Timmers, C., Altura, R., Tokuyama, Y., Fukasawa, K., Leone, G. Cancer Cell (2003)
- Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice. Gu, M., Singh, R.P., Dhanalakshmi, S., Mohan, S., Agarwal, R. Mol. Cancer Ther. (2006)
- Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Callaghan, D.A., Dong, L., Callaghan, S.M., Hou, Y.X., Dagnino, L., Slack, R.S. Dev. Biol. (1999)
- Combinatorial gene control involving E2F and E Box family members. Giangrande, P.H., Zhu, W., Rempel, R.E., Laakso, N., Nevins, J.R. EMBO J. (2004)