MeSH Review:
Kringles
- Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma. Torimura, T., Ueno, T., Kin, M., Taniguchi, E., Nakamura, T., Inoue, K., Sakata, R., Hashimoto, O., Sakamoto, M., Ohira, H., Kumashiro, R., Sata, M., Yano, H., Kojiro, M., Veitonmaki, N., Cao, Y. Gastroenterology (2006)
- The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis. Mukhina, S., Stepanova, V., Traktouev, D., Poliakov, A., Beabealashvilly, R., Gursky, Y., Minashkin, M., Shevelev, A., Tkachuk, V. J. Biol. Chem. (2000)
- Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5. Gao, G., Li, Y., Gee, S., Dudley, A., Fant, J., Crosson, C., Ma, J.X. J. Biol. Chem. (2002)
- Inhibition of human malignant glioma growth in vivo by human recombinant plasminogen kringles 1-3. Joe, Y.A., Hong, Y.K., Chung, D.S., Yang, Y.J., Kang, J.K., Lee, Y.S., Chang, S.I., You, W.K., Lee, H., Chung, S.I. Int. J. Cancer (1999)
- Prothrombin and its derivatives stimulate motility of melanoma cells. Zhou, H., Gabazza, E.C., Takeya, H., Deguchi, H., Urano, H., Adachi, Y., Suzuki, K. Thromb. Haemost. (1998)
- Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Afzal, A.R., Rajab, A., Fenske, C.D., Oldridge, M., Elanko, N., Ternes-Pereira, E., Tüysüz, B., Murday, V.A., Patton, M.A., Wilkie, A.O., Jeffery, S. Nat. Genet. (2000)
- Binding of disease-associated prion protein to plasminogen. Fischer, M.B., Roeckl, C., Parizek, P., Schwarz, H.P., Aguzzi, A. Nature (2000)
- Atherogenesis in transgenic mice expressing human apolipoprotein(a). Lawn, R.M., Wade, D.P., Hammer, R.E., Chiesa, G., Verstuyft, J.G., Rubin, E.M. Nature (1992)
- Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes. Klezovitch, O., Edelstein, C., Scanu, A.M. J. Clin. Invest. (1996)
- alpha-Fucose-mediated binding and degradation of tissue-type plasminogen activator by HepG2 cells. Hajjar, K.A., Reynolds, C.M. J. Clin. Invest. (1994)
- Construction, expression, and purification of recombinant kringle 1 of human plasminogen and analysis of its interaction with omega-amino acids. Menhart, N., Sehl, L.C., Kelley, R.F., Castellino, F.J. Biochemistry (1991)
- Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin. Humphries, J.E., Vasudevan, J., Gonias, S.L. Arterioscler. Thromb. (1993)
- The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. Weidner, K.M., Sachs, M., Birchmeier, W. J. Cell Biol. (1993)
- Deriving the generic structure of the fibronectin type II domain from the prothrombin Kringle 1 crystal structure. Holland, S.K., Harlos, K., Blake, C.C. EMBO J. (1987)
- RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. Gaudino, G., Follenzi, A., Naldini, L., Collesi, C., Santoro, M., Gallo, K.A., Godowski, P.J., Comoglio, P.M. EMBO J. (1994)
- The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains. Ny, T., Elgh, F., Lund, B. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Chirgadze, D.Y., Hepple, J.P., Zhou, H., Byrd, R.A., Blundell, T.L., Gherardi, E. Nat. Struct. Biol. (1999)
- Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Cao, R., Wu, H.L., Veitonmäki, N., Linden, P., Farnebo, J., Shi, G.Y., Cao, Y. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment. Chavakis, T., Athanasopoulos, A., Rhee, J.S., Orlova, V., Schmidt-Wöll, T., Bierhaus, A., May, A.E., Celik, I., Nawroth, P.P., Preissner, K.T. Blood (2005)
- Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. Matsumoto, K., Kataoka, H., Date, K., Nakamura, T. J. Biol. Chem. (1998)
- Angiostatin binds to smooth muscle cells in the coronary artery and inhibits smooth muscle cell proliferation and migration In vitro. Walter, J.J., Sane, D.C. Arterioscler. Thromb. Vasc. Biol. (1999)
- Characterization of the binding of plasminogen activators to plasma membranes from human liver. Nguyen, G., Self, S.J., Camani, C., Kruithof, E.K. Biochem. J. (1992)
- cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. McLean, J.W., Tomlinson, J.E., Kuang, W.J., Eaton, D.L., Chen, E.Y., Fless, G.M., Scanu, A.M., Lawn, R.M. Nature (1987)
- Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor. Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E. EMBO J. (2001)
- Structural features of the kringle domain determine the intracellular degradation of under-gamma-carboxylated prothrombin: studies of chimeric rat/human prothrombin. Wu, W., Bancroft, J.D., Suttie, J.W. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Novel therapeutic strategy for atherosclerosis: ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression. Morishita, R., Yamada, S., Yamamoto, K., Tomita, N., Kida, I., Sakurabayashi, I., Kikuchi, A., Kaneda, Y., Lawn, R., Higaki, J., Ogihara, T. Circulation (1998)
- Muscle-specific trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases. Jennings, C.G., Dyer, S.M., Burden, S.J. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen. DePoli, P., Bacon-Baguley, T., Kendra-Franczak, S., Cederholm, M.T., Walz, D.A. Blood (1989)
- NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. Jakubczak, J.L., LaRochelle, W.J., Merlino, G. Mol. Cell. Biol. (1998)
- Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration. Pluskota, E., Soloviev, D.A., Plow, E.F. Blood (2003)
- Thermodynamic properties of the binding of alpha-, omega-amino acids to the isolated kringle 4 region of human plasminogen as determined by high sensitivity titration calorimetry. Sehl, L.C., Castellino, F.J. J. Biol. Chem. (1990)
- The lysine binding sites of human plasminogen. Evidence for a critical tryptophan in the binding site of kringle 4. Hochschwender, S.M., Laursen, R.A. J. Biol. Chem. (1981)
- Human plasminogen kringle 4. Crystallization and preliminary diffraction data of two different crystal forms. Mulichak, A.M., Park, C.H., Tulinsky, A., Petros, A.M., Llinás, M. J. Biol. Chem. (1989)
- Quantitative evaluation of the contribution of weak lysine-binding sites present within apolipoprotein(a) kringle IV types 6-8 to lipoprotein(a) assembly. Becker, L., Cook, P.M., Wright, T.G., Koschinsky, M.L. J. Biol. Chem. (2004)
- The interaction of prothrombin with phospholipid membranes is independent of either kringle domain. Kotkow, K.J., Furie, B., Furie, B.C. J. Biol. Chem. (1993)