Gene Review:
TUBB3 - tubulin, beta 3 class III
Homo sapiens
Synonyms:
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, ...
- Loss of beta4 integrin subunit reduces the tumorigenicity of MCF7 mammary cells and causes apoptosis upon hormone deprivation. Bon, G., Folgiero, V., Bossi, G., Felicioni, L., Marchetti, A., Sacchi, A., Falcioni, R. Clin. Cancer Res. (2006)
- p53 codon 72 Pro homozygosity increases the risk of cutaneous melanoma in individuals with dark skin complexion and among noncarriers of melanocortin 1 receptor red hair variants. Stefanaki, I., Stratigos, A.J., Dimisianos, G., Nikolaou, V., Papadopoulos, O., Polydorou, D., Gogas, H., Tsoutsos, D., Panagiotou, P., Kanavakis, E., Antoniou, C., Katsambas, A.D. Br. J. Dermatol. (2007)
- Crucial role of the melanocortin receptor MC1R in experimental colitis. Maaser, C., Kannengiesser, K., Specht, C., Lügering, A., Brzoska, T., Luger, T.A., Domschke, W., Kucharzik, T. Gut (2006)
- Integrin alpha6beta4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer. Ishii, Y., Ochiai, A., Yamada, T., Akimoto, S., Yanagihara, K., Kitajima, M., Hirohashi, S. Gastroenterology (2000)
- Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice. Oyama, F., Miyazaki, H., Sakamoto, N., Becquet, C., Machida, Y., Kaneko, K., Uchikawa, C., Suzuki, T., Kurosawa, M., Ikeda, T., Tamaoka, A., Sakurai, T., Nukina, N. J. Neurochem. (2006)
- IL-1 beta decreases expression of amyloid precursor protein gene in human glioma cells. Yang, F., Jansen, L., Friedrichs, W.E., Buchanan, J.M., Bowman, B.H. Biochem. Biophys. Res. Commun. (1993)
- Modelling the influence of fat-free mass and physical activity on the decline in maximal oxygen uptake with age in older humans. Amara, C.E., Koval, J.J., Johnson, P.J., Paterson, D.H., Winter, E.M., Cunningham, D.A. Exp. Physiol. (2000)
- Febrile convulsions, ataxia, developmental delay, and obesity: a new syndrome? Lev, D., Watemberg, N., Aviram, A., Fishoff, J., Antman, E., Lerman-Sagie, T. J. Child Neurol. (2001)
- Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. Salas, R., Pieri, F., De Biasi, M. J. Neurosci. (2004)
- Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. McIntosh, J.M., Santos, A.D., Olivera, B.M. Annu. Rev. Biochem. (1999)
- ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Muthuswamy, S.K. Cell (2006)
- Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., Le Meur, M. Nat. Genet. (1996)
- Expression of a ryanodine receptor-Ca2+ channel that is regulated by TGF-beta. Giannini, G., Clementi, E., Ceci, R., Marziali, G., Sorrentino, V. Science (1992)
- Expression of alpha-3, alpha-5, and beta-4 neuronal acetylcholine receptor subunit transcripts in normal and myasthenia gravis thymus. Identification of thymocytes expressing the alpha-3 transcripts. Mihovilovic, M., Roses, A.D. J. Immunol. (1993)
- Gene correction of integrin beta4-dependent pyloric atresia-junctional epidermolysis bullosa keratinocytes establishes a role for beta4 tyrosines 1422 and 1440 in hemidesmosome assembly. Dellambra, E., Prislei, S., Salvati, A.L., Madeddu, M.L., Golisano, O., Siviero, E., Bondanza, S., Cicuzza, S., Orecchia, A., Giancotti, F.G., Zambruno, G., De Luca, M. J. Biol. Chem. (2001)
- Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins. Hötzel, I., Cheevers, W.P. J. Virol. (2001)
- Beta 1 and beta 4 integrin expression in methacarn and formalin-fixed material from in situ ductal carcinoma of the breast. Hanby, A.M., Gillett, C.E., Pignatelli, M., Stamp, G.W. J. Pathol. (1993)
- Destruction of the epithelial anchoring system in lichen planus. Haapalainen, T., Oksala, O., Kallioinen, M., Oikarinen, A., Larjava, H., Salo, T. J. Invest. Dermatol. (1995)
- Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2]. An additional binding site within the human melanocortin receptor 1? Koikov, L.N., Ebetino, F.H., Solinsky, M.G., Cross-Doersen, D., Knittel, J.J. Bioorg. Med. Chem. Lett. (2004)
- Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine. Marks, M.J., Whiteaker, P., Collins, A.C. Mol. Pharmacol. (2006)
- Truncated RAR beta isoform enhances proliferation and retinoid resistance. Swift, M.E., Wallden, B., Wayner, E.A., Swisshelm, K. J. Cell. Physiol. (2006)
- Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol). Dumontet, C., Duran, G.E., Steger, K.A., Beketic-Oreskovic, L., Sikic, B.I. Cancer Res. (1996)
- Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose Ganglia. Mao, D., Yasuda, R.P., Fan, H., Wolfe, B.B., Kellar, K.J. Mol. Pharmacol. (2006)
- Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes. Nieves-Cintr??n, M., Caballero-Rivera, D., Navedo, M.F., Lasalde-Dominicci, J.A. J. Neurosci. Res. (2006)
- Nicotine: the link between cigarette smoking and the progression of renal injury? Jaimes, E.A., Tian, R.X., Raij, L. Am. J. Physiol. Heart Circ. Physiol. (2007)
- Characterization of the integrin receptor subunit profile in the mammalian sclera. Metlapally, R., Jobling, A.I., Gentle, A., McBrien, N.A. Mol. Vis. (2006)
- Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Gotti, C., Zoli, M., Clementi, F. Trends Pharmacol. Sci. (2006)
- Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca2+-Activated K+ Channel Activators Selective for beta1 and beta4 but Not for beta2 Subunits. Morimoto, T., Sakamoto, K., Sade, H., Ohya, S., Muraki, K., Imaizumi, Y. Mol. Pharmacol. (2007)
- Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat. Smith, J.W., Mogg, A., Tafi, E., Peacey, E., Pullar, I.A., Szekeres, P., Tricklebank, M. Psychopharmacology (Berl.) (2007)
- Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin. Litjens, S.H., Wilhelmsen, K., de Pereda, J.M., Perrakis, A., Sonnenberg, A. J. Biol. Chem. (2005)
- Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. Jin, P., Weiger, T.M., Levitan, I.B. J. Biol. Chem. (2002)
- The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. Abdel-Ghany, M., Cheng, H.C., Elble, R.C., Lin, H., DiBiasio, J., Pauli, B.U. J. Biol. Chem. (2003)
- Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Niessen, C.M., Hulsman, E.H., Rots, E.S., Sánchez-Aparicio, P., Sonnenberg, A. Mol. Biol. Cell (1997)
- Loss of co-localization of alpha 6 beta 4 integrin and collagen VII in bladder cancer. Liebert, M., Washington, R., Wedemeyer, G., Carey, T.E., Grossman, H.B. Am. J. Pathol. (1994)
- Incorporation of the beta3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors. Broadbent, S., Groot-Kormelink, P.J., Krashia, P.A., Harkness, P.C., Millar, N.S., Beato, M., Sivilotti, L.G. Mol. Pharmacol. (2006)
- Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. Chung, J., Bachelder, R.E., Lipscomb, E.A., Shaw, L.M., Mercurio, A.M. J. Cell Biol. (2002)
- p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells. Mainiero, F., Colombara, M., Antonini, V., Strippoli, R., Merola, M., Poffe, O., Tridente, G., Ramarli, D. Eur. J. Immunol. (2003)
- Time-dependent folding of immunological epitopes of the human chorionic gonadotropin beta-subunit. Roig, J., Krause, J.M., Berger, P., Merz, W.E. Mol. Cell. Endocrinol. (2007)
- Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Leung, Y.K., Mak, P., Hassan, S., Ho, S.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. Schaapveld, R.Q., Borradori, L., Geerts, D., van Leusden, M.R., Kuikman, I., Nievers, M.G., Niessen, C.M., Steenbergen, R.D., Snijders, P.J., Sonnenberg, A. J. Cell Biol. (1998)
- Palmitoylation supports assembly and function of integrin-tetraspanin complexes. Yang, X., Kovalenko, O.V., Tang, W., Claas, C., Stipp, C.S., Hemler, M.E. J. Cell Biol. (2004)
- Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells. Nilbratt, M., Friberg, L., Mousavi, M., Marutle, A., Nordberg, A. J. Neurosci. Res. (2007)
- Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. Galvis, G., Lips, K.S., Kummer, W. J. Mol. Neurosci. (2006)
- Uveal Melanocytes Do Not Respond To or Express Receptors for {alpha}-Melanocyte-Stimulating Hormone. Li, L., Hu, D.N., Zhao, H., McCormick, S.A., Nordlund, J.J., Boissy, R.E. Invest. Ophthalmol. Vis. Sci. (2006)