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Gene Review

Hdac4  -  histone deacetylase 4

Mus musculus

Synonyms: 4932408F19Rik, AI047285, HD4, Histone deacetylase 4
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Disease relevance of Hdac4


High impact information on Hdac4


Biological context of Hdac4


Anatomical context of Hdac4


Associations of Hdac4 with chemical compounds

  • However, in response to low-potassium or excitotoxic glutamate conditions that induce neuronal cell death, HDAC4 rapidly translocates into the nucleus of cultured CGNs [4].

Other interactions of Hdac4


Analytical, diagnostic and therapeutic context of Hdac4


  1. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Vega, R.B., Matsuda, K., Oh, J., Barbosa, A.C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J.M., Richardson, J.A., Karsenty, G., Olson, E.N. Cell (2004) [Pubmed]
  2. DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. Basile, V., Mantovani, R., Imbriano, C. J. Biol. Chem. (2006) [Pubmed]
  3. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. Tuddenham, L., Wheeler, G., Ntounia-Fousara, S., Waters, J., Hajihosseini, M.K., Clark, I., Dalmay, T. FEBS Lett. (2006) [Pubmed]
  4. Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. Bolger, T.A., Yao, T.P. J. Neurosci. (2005) [Pubmed]
  5. Stage specific expression of histone deacetylase 4 (HDAC4) during oogenesis and early preimplantation development in mice. Kageyama, S., Liu, H., Nagata, M., Aoki, F. J. Reprod. Dev. (2006) [Pubmed]
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