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Gene Review

Morf4l1  -  mortality factor 4 like 1

Mus musculus

Synonyms: MORF-related gene 15 protein, MORFRG15, MRG15, Mortality factor 4-like protein 1, Mrg15, ...
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Disease relevance of Morf4l1


High impact information on Morf4l1


Biological context of Morf4l1

  • Characterization of the expression pattern of mouse MrgX demonstrated it was ubiquitously expressed in all tissues of adult mice and also during embryogenesis and overlapped with its homolog Mrg15 [2].
  • MRG15 associates with at least two nucleoprotein complexes that include histone acetyltransferases and/or histone deacetylases, suggesting it is involved in chromatin remodeling [1].
  • Immunohistochemical analysis indicates that apoptosis in Mrg15-/- embryos is not increased compared with wild-type littermates [1].
  • The mouse MRG15 gene is composed of twelve exons and spans over 24 kb DNA [3].
  • Pf1 has independent binding sites for MRG15 and mSin3A [4].

Anatomical context of Morf4l1


Other interactions of Morf4l1


  1. MRG15 regulates embryonic development and cell proliferation. Tominaga, K., Kirtane, B., Jackson, J.G., Ikeno, Y., Ikeda, T., Hawks, C., Smith, J.R., Matzuk, M.M., Pereira-Smith, O.M. Mol. Cell. Biol. (2005) [Pubmed]
  2. MrgX is not essential for cell growth and development in the mouse. Tominaga, K., Matzuk, M.M., Pereira-Smith, O.M. Mol. Cell. Biol. (2005) [Pubmed]
  3. The genomic organization, promoter position and expression profile of the mouse MRG15 gene. Tominaga, K., Pereira-Smith, O.M. Gene (2002) [Pubmed]
  4. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. Yochum, G.S., Ayer, D.E. Mol. Cell. Biol. (2002) [Pubmed]
  5. A chromodomain-containing nuclear protein, MRG15 is expressed as a novel type of dendritic mRNA in neurons. Matsuoka, Y., Matsuoka, Y., Shibata, S., Ban, T., Toratani, N., Shigekawa, M., Ishida, H., Yoneda, Y. Neurosci. Res. (2002) [Pubmed]
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