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Ube2b  -  ubiquitin-conjugating enzyme E2B

Mus musculus

Synonyms: 2610301N02Rik, E2-14k, E214K, HR6B, RAD6 homolog B, ...
 
 
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Disease relevance of Ube2b

 

High impact information on Ube2b

 

Biological context of Ube2b

 

Anatomical context of Ube2b

  • Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant [1].
 

Other interactions of Ube2b

  • Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice [6].
 

Analytical, diagnostic and therapeutic context of Ube2b

References

  1. Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant. Escalier, D., Bai, X.Y., Silvius, D., Xu, P.X., Xu, X. Mol. Reprod. Dev. (2003) [Pubmed]
  2. Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification. Roest, H.P., van Klaveren, J., de Wit, J., van Gurp, C.G., Koken, M.H., Vermey, M., van Roijen, J.H., Hoogerbrugge, J.W., Vreeburg, J.T., Baarends, W.M., Bootsma, D., Grootegoed, J.A., Hoeijmakers, J.H. Cell (1996) [Pubmed]
  3. The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Roest, H.P., Baarends, W.M., de Wit, J., van Klaveren, J.W., Wassenaar, E., Hoogerbrugge, J.W., van Cappellen, W.A., Hoeijmakers, J.H., Grootegoed, J.A. Mol. Cell. Biol. (2004) [Pubmed]
  4. Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Baarends, W.M., Wassenaar, E., Hoogerbrugge, J.W., van Cappellen, G., Roest, H.P., Vreeburg, J., Ooms, M., Hoeijmakers, J.H., Grootegoed, J.A. Mol. Cell. Biol. (2003) [Pubmed]
  5. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Liebe, B., Petukhova, G., Barchi, M., Bellani, M., Braselmann, H., Nakano, T., Pandita, T.K., Jasin, M., Fornace, A., Meistrich, M.L., Baarends, W.M., Schimenti, J., de Lange, T., Keeney, S., Camerini-Otero, R.D., Scherthan, H. Exp. Cell Res. (2006) [Pubmed]
  6. Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice. Adegoke, O.A., Bédard, N., Roest, H.P., Wing, S.S. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
 
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