Disease relevance of Ube2b

• Ube2b(-/-) mice were shown to present male infertility and their sperm head shape anomalies suggested that Ube2b may be involved in the replacement of nuclear proteins during spermatid chromatin condensation [1].

High impact information on Ube2b

• Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification [2].
• These observations support redundant but dose-dependent roles for HR6A and HR6B in somatic cell types and germ line cells in mammals [3].
• In the present study, increased apoptosis of HR6B knockout primary spermatocytes was detected during the first wave of spermatogenesis, indicating that HR6B performs a primary role during the meiotic prophase [4].
• HR6B knockout mice are viable, but spermatogenesis is markedly affected during postmeiotic steps, leading to male infertility [4].
• Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase [4].

Biological context of Ube2b

• Apoptosis of spermatocytes suggested additional targets of Ube2b during spermatogenesis [1].
• The generally low frequencies of mid-preleptotene spermatocytes were significantly increased in male mice lacking recombination proteins SPO11, MEI1, MLH1, KU80, ubiquitin conjugating enzyme HR6B, and in mice with only one copy of the telomere length regulator Terf1 [5].

Anatomical context of Ube2b

• Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant [1].

Other interactions of Ube2b

• Ubiquitin-conjugating enzyme E214k/HR6B is dispensable for increased protein catabolism in muscle of fasted mice [6].

Analytical, diagnostic and therapeutic context of Ube2b

• Consistently, we found Ube2b transcription in both meiotic and postmeiotic stages by in situ hybridization [1].

References