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Gene Review

Sycp1  -  synaptonemal complex protein 1

Mus musculus

Synonyms: SCP-1, SCP1, Scp1, Synaptonemal complex protein 1
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Disease relevance of Sycp1


High impact information on Sycp1


Chemical compound and disease context of Sycp1


Biological context of Sycp1


Anatomical context of Sycp1


Associations of Sycp1 with chemical compounds

  • By synthesis of SCP3 in cultured somatic cells, it has been shown that SCP3 can self-assemble into thick fibers and that this process requires the COOH-terminal coiled coil domain of SCP3, as well as the NH2-terminal nonhelical domain [8].
  • These nuclear synaptonemal complex-matrices are prepared by extracting Triton X-100-treated nuclei with low (0.2 M) and high (1.0 or 2.0 M) NaCl, DNase I, and RNase A to remove 85% of the nuclear proteins, 97% of the RNA, and 99% of the DNA [13].
  • Since the BALB/c-specific PR1 family B is not present in DDD/1 or MOA mice, the unpaired portion of the BALB/c chromosome may be looped out in a synaptonemal complex during meiosis in F1 hybrids of the BALB/c strain with DDD/1 or MOA [14].
  • Ultrathin sections of osmium tetroxide/p-phenylenediamine treated material showed that, under the electron microscope, this technique stains preferentially elements of the synaptonemal complex, while the surrounding chromatin remains unstained [15].
  • The use of osmium tetroxide fixation followed by postreatment with p-phenylenediamine gives an opportunity of locating the synaptonemal complex (SC) under the light microscope in mouse testes and Allium cepa anthers [15].

Other interactions of Sycp1


Analytical, diagnostic and therapeutic context of Sycp1


  1. Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Eaker, S., Cobb, J., Pyle, A., Handel, M.A. Dev. Biol. (2002) [Pubmed]
  2. Chromosome aberrations in F1 from irradiated male mice studied by their synaptonemal complexes. Kalikinskaya, E.I., Kolomiets, O.L., Shevchenko, V.A., Bogdanov, Y.F. Mutat. Res. (1986) [Pubmed]
  3. Synaptonemal complex analysis in spermatocytes and oocytes of tertiary trisomic Ts(512)31H mice with male sterility. Mahadevaiah, S., Mittwoch, U. Cytogenet. Cell Genet. (1986) [Pubmed]
  4. Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex. Moses, M.J., Russel, L.B., Cacheiro, N.L. Science (1977) [Pubmed]
  5. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. de Vries, F.A., de Boer, E., van den Bosch, M., Baarends, W.M., Ooms, M., Yuan, L., Liu, J.G., van Zeeland, A.A., Heyting, C., Pastink, A. Genes Dev. (2005) [Pubmed]
  6. Synaptonemal complex damage in relation to meiotic chromosome aberrations after exposure of male mice to cyclophosphamide. Backer, L.C., Gibson, J.B., Moses, M.J., Allen, J.W. Mutat. Res. (1988) [Pubmed]
  7. The Sycp1 loci of the mouse genome: successive retropositions of a meiotic gene during the recent evolution of the genus. Sage, J., Yuan, L., Martin, L., Mattei, M.G., Guénet, J.L., Liu, J.G., Hoög, C., Rassoulzadegan, M., Cuzin, F. Genomics (1997) [Pubmed]
  8. The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivo. Yuan, L., Pelttari, J., Brundell, E., Björkroth, B., Zhao, J., Liu, J.G., Brismar, H., Daneholt, B., Höög, C. J. Cell Biol. (1998) [Pubmed]
  9. Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. Prieto, I., Suja, J.A., Pezzi, N., Kremer, L., Martínez-A, C., Rufas, J.S., Barbero, J.L. Nat. Cell Biol. (2001) [Pubmed]
  10. Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary. McClellan, K.A., Gosden, R., Taketo, T. Dev. Biol. (2003) [Pubmed]
  11. Tesmin transcription is regulated differently during male and female meiosis. Olesen, C., Møller, M., Byskov, A.G. Mol. Reprod. Dev. (2004) [Pubmed]
  12. Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice. Tay, J., Richter, J.D. Dev. Cell (2001) [Pubmed]
  13. Synaptonemal complexes are integral components of the isolated mouse spermatocyte nuclear matrix. Ierardi, L.A., Moss, S.B., Bellvé, A.R. J. Cell Biol. (1983) [Pubmed]
  14. A polymorphic repetitive-sequence PR1 family. Evidence for meiotic instability. Kominami, R., Sudo, K., Yoshikura, H., Suzuki, H., Moriwaki, K., Hilgers, J., Muramatsu, M. J. Mol. Biol. (1985) [Pubmed]
  15. Localization of the synaptonemal complex under the light microscope. Esponda, P., Stockert, J.C. Chromosoma (1978) [Pubmed]
  16. Germ cell-specific enhancer activity of a repeated element in a variable region of the mouse genome. Sage, J., Martin, L., Rassoulzadegan, M., Cuzin, F. Gene (1998) [Pubmed]
  17. Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I. Parra, M.T., Viera, A., Gómez, R., Page, J., Benavente, R., Santos, J.L., Rufas, J.S., Suja, J.A. J. Cell. Sci. (2004) [Pubmed]
  18. Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Baarends, W.M., Wassenaar, E., Hoogerbrugge, J.W., van Cappellen, G., Roest, H.P., Vreeburg, J., Ooms, M., Hoeijmakers, J.H., Grootegoed, J.A. Mol. Cell. Biol. (2003) [Pubmed]
  19. A new role for the mitotic RAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse. Xu, H., Beasley, M., Verschoor, S., Inselman, A., Handel, M.A., McKay, M.J. EMBO Rep. (2004) [Pubmed]
  20. Immunocytology of chiasmata and chromosomal disjunction at mouse meiosis. Moens, P.B., Spyropoulos, B. Chromosoma (1995) [Pubmed]
  21. Atm inactivation results in aberrant telomere clustering during meiotic prophase. Pandita, T.K., Westphal, C.H., Anger, M., Sawant, S.G., Geard, C.R., Pandita, R.K., Scherthan, H. Mol. Cell. Biol. (1999) [Pubmed]
  22. Colchicine effects on meiosis in the male mouse. I. Meiotic prophase: synaptic arrest, univalents, loss of damaged spermatocytes and a possible checkpoint at pachytene. Tepperberg, J.H., Moses, M.J., Nath, J. Chromosoma (1997) [Pubmed]
  23. Silver-stained structures in mammalian meiotic prophase. Pathak, S., Hsu, T.C. Chromosoma (1979) [Pubmed]
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