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Gene Review

Slc6a18  -  solute carrier family 6 (neurotransmitter...

Mus musculus

Synonyms: B0AT3, D630001K16Rik, Sodium-and chloride-dependent transporter XTRP2, Sodium-dependent neutral amino acid transporter B(0)AT3, Solute carrier family 6 member 18, ...
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High impact information on Slc6a18


Biological context of Slc6a18


Anatomical context of Slc6a18

  • Screening experiments to identify the substrate(s) of these proteins failed to identify specific uptake with any of the tested compounds; however, immunofluorescent microscopy demonstrated that epitope-tagged variants of the protein products of the XT2 and XT3 cDNAs were present on the plasma membrane of transfected cells [3].

Analytical, diagnostic and therapeutic context of Slc6a18

  • To study the physiological functions of this transporter, we generated XT2-knockout mice by gene targeting [1].
  • To attempt to identify potential substrates for XT2, we screened urine from XT2-knockout mice by high-pressure liquid chromatography and mass spectrometry and found significantly elevated concentrations of glycine [1].


  1. Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Quan, H., Athirakul, K., Wetsel, W.C., Torres, G.E., Stevens, R., Chen, Y.T., Coffman, T.M., Caron, M.G. Mol. Cell. Biol. (2004) [Pubmed]
  2. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Romeo, E., Dave, M.H., Bacic, D., Ristic, Z., Camargo, S.M., Loffing, J., Wagner, C.A., Verrey, F. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  3. Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Nash, S.R., Giros, B., Kingsmore, S.F., Kim, K.M., el-Mestikawy, S., Dong, Q., Fumagalli, F., Seldin, M.F., Caron, M.G. Recept. Channels (1998) [Pubmed]
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