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Gene Review

IKZF2  -  IKAROS family zinc finger 2 (Helios)

Homo sapiens

Synonyms: ANF1A2, HELIOS, Helios, Ikaros family zinc finger protein 2, ZNF1A2, ...


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IKZF2 encodes the protein Helios, and belongs to the Ikaros family of zinc finger transcription factors. Murine Helios (Ikzf2) was discovered in 1998 by two independent groups [Hahm et al., Genes Dev., 1998; Kelley et al., Curr Biol, 1998], and the human gene IKZF2 was cloned the next year [Hosokawa et al., Immunogenetics, 1999].



Helios is most abundantly expressed and most extensively studied in the T cells of the hematopoietic system. However, Helios is also expressed in other hematopoietic cells as well as in some other tissues.


Disease relevance of IKZF2



Expression and conservation of IKZF2



Biological context of IKZF2



Anatomical context of IKZF2

  • RESULTS: We found overexpression of novel short isoforms of Helios (Hel-5 and Hel-6) in the HD-Mar cell line [2].




Analytical, diagnostic and therapeutic context of IKZF2


  1. Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. Hosokawa, Y., Maeda, Y., Seto, M. Immunogenetics (1999) [Pubmed]
  2. Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. Nakase, K., Ishimaru, F., Fujii, K., Tabayashi, T., Kozuka, T., Sezaki, N., Matsuo, Y., Harada, M. Exp. Hematol. (2002) [Pubmed]
  3. Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma. Fujii, K., Ishimaru, F., Nakase, K., Tabayashi, T., Kozuka, T., Naoki, K., Miyahara, M., Toki, H., Kitajima, K., Harada, M., Tanimoto, M. Br. J. Haematol. (2003) [Pubmed]
  4. Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors. Durand, C., Kerfourn, F., Charlemagne, J., Fellah, J.S. Eur. J. Immunol. (2002) [Pubmed]
  5. Expression of a unique helios isoform in human leukemia cells. Sun, L., Kerawalla, H., Wu, X., Lehnert, M.S., Uckun, F.M. Leuk. Lymphoma (2002) [Pubmed]
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