Disease relevance of Asah3l

• The effects of phorbol esters on mammary epithelial cells from BALB/cfC3H/Crgl "midpregnant mice" (i.e., mice at the midterm of pregnancy) and from mammary adenocarcinomas (also from BALB/cfC3H/Crgl mice) grown in a collagen gel matrix were studied [1].
• The strain BALB/cNIV/Crgl was developed by infecting BALB/c/Crgl mice with mouse mammary tumor virus from C3Hf mice [2].
• A murine model of spontaneous metastasis of mammary adenocarcinomas in mice was developed by serial transplantation of spontaneous BALB/cfC3H/ Crgl tumours into the mammary gland [3].
• A diurnal rhythmicity in plasma corticosterone levels was demonstrated in female BALB/cCrgl and C3H/Crgl mice, with and without mammary tumor virus [4].

High impact information on Asah3l

• Coding potential of the Q6 gene from the Qa-2a region of BALB/c Crgl mice was analyzed by a combination of hybrid class I gene construction and DNA-mediated gene transfer [5].
• Female mice from three inbred strains (BALB/cCrgl, C3H/Crgl, and C57BL/Crgl) and one noninbred stock [RU:NCS (RU)] were treated perinatally with estradiol benzoate (EB), diethylstilbestrol (DES), or sesame oil and were killed on postnatal days 30--36 [6].
• Mammary epithelial cells from C57BL/Crgl virgin donors grown in collagen gels for 10 to 14 days retained their ability to respond to the endogenous hormones of pregnancy and lactation of the host and formed lobuloalveolar structures full of secretion similar to the host's own mammary gland [7].
• Reproductive tract calculi, their induction, age incidence, composition and biological effects in Balb/c Crgl mice injected as newborns with estradiol-17 beta [8].
• Newborn C57BL/Crgl mice received 8 x 10(-2) micrograms diethylstilbestrol (DES) or 100 micrograms coumestrol (a plant estrogen) in 0.005 mL dimethyl sulfoxide (DMSO) or DMSO alone or received no treatment for the first 5 days of life [9].

Biological context of Asah3l

• The TDM phi bearing haplotype H-2k (C3H/Crgl, CBA/LAC) proliferated more rapidly than TDM phi derived from mouse strains bearing the haplotypes of H-2b (C57BL/6), H-2d (BALB/c) and H-2k/d (A/J) [10].

Anatomical context of Asah3l

• Live, adult Schistosoma mansoni, recovered from the hepatic and mesenteric veins of C3H/Crgl (H-2k) mice, displayed H-2 antigens on the tegumental surface [11].

Associations of Asah3l with chemical compounds

• Reproductive alterations in female C57BL/Crgl mice exposed neonatally to zearalenone, an estrogenic mycotoxin [12].
• Adrenal hormones and ethanol ingestion in C57BL/Crgl and C3H/Crgl/2 mice [13].

Analytical, diagnostic and therapeutic context of Asah3l

• Transformed nodule and ductal mammary cells were recovered by cell dissociation and transplantation of mammary cells from C57BL/Crgl mice treated with 7,12-dimethylbenz(a)anthracene [14].
• Newborn female C57BL/Crgl mice were given daily subcutaneous injections of 0.08 micrograms DES or 100 micrograms coumestrol in 0.005 ml dimethyl sulfoxide (DMSO), or DMSO alone, or were untreated, for the first 5 d of life [15].

References