Disease relevance of DNMBP

• We propose that Tuba facilitates dorsal ruffling of melanoma cells through direct interaction with actin-regulatory proteins and the recruitment of signaling molecules to lipid microdomains for the coordinated assembly of a cytoskeletal network [1].
• We investigated Tuba localization, distribution and function in B16 melanoma cells [1].
• The numbers of patients admitted to the Public Health Service Indian Hospital, in Tuba City, Arizona, with deficits in weight for their chronological ages, marasmus, and kwashiorkor were compared during two 5-year-periods, 1963 to 1967 and 1969 to 1973 [2].
• The ultrastructure of a poorly differentiated adenocarcinoma of the human tuba uterina [3].
• One year previously she had undergone hysterectomy and adnexectomy due to an endometrial stromal sarcoma with involvement of the tuba [4].

Psychiatry related information on DNMBP

• Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease [5].

High impact information on DNMBP

• Tuba RNAi also retarded cell junction formation in calcium-switch experiments [6].
• Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells [6].
• Thus, we confirmed the association of DNMBP with AD individuals with the APOE-epsilon3*3 genotype or lacking the epsilon4 allele, and DNMBP may be one of the susceptibility genes for AD [5].
• These SNPs were clustered in a locus spanning 220 kb at genomic position 101 Mb, and three of the six SNPs were located in the dynamin-binding protein (DNMBP) gene [5].
• Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones [7].

Biological context of DNMBP

• Knockdown of Tuba by RNA interference (RNAi) attenuated PIP5Kalpha-generated comet formation and the invasive behavior of B16 cells, implying that Tuba function is required for certain aspects of these processes [1].

Anatomical context of DNMBP

• Topographical relationships and size of the arteries of the mesovarium and mesosalpinx were evaluated from the point of view of their usefulness in microsurgical operations on the oviduct (tuba uterina) [8].
• The findings have shown a discrepancy between the microbiological isolation from vagina/endocervix and from salpinx and remarkably the loss of evidence of S.T.D. agents from tuba with, conversely, frequent isolation of these agents (34.7%) from cervical swabs [9].

Associations of DNMBP with chemical compounds

• Additionally, Tuba was recruited to lipid vesicles generated by overexpression of phosphatidylinositol-4-phosphate 5-kinase type Ialpha (PIP5Kalpha), localizing prominently to the head of the comets and at lower levels along the actin tail [1].
• We attempted to restore native plants on disturbed sites at a former uranium mill on the Colorado Plateau near Tuba City, AZ [10].
• Tuba is a 178kD protein containing four NH2-terminal SH3 domains, a central Dbl homology (DH) domain followed by a BAR domain, and two COOH-terminal SH3 domains [11].

Other interactions of DNMBP

• Intersectin is a multidomain dynamin-binding protein implicated in numerous functions in the nervous system, including synapse formation and endocytosis [12].

Analytical, diagnostic and therapeutic context of DNMBP

• Quantitative real-time RT-PCR analysis demonstrated that neuropathologically confirmed AD brains exhibit a significant reduction of DNMBP mRNA compared with age-matched ones (P<0.0169) [5].
• Endoscopic bilateral augmentation mammaplasty through a transumbilical approach ("TUBA") has recently been advocated as an alternative technique [13].

References