Gene Review:
Rasa1 - RAS p21 protein activator 1
Mus musculus
Synonyms:
Gap, RasGAP, Rasa, p120-rasGAP
- Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily. Tsuji, T., Yamamoto, F., Miura, Y., Takio, K., Titani, K., Pawar, S., Osawa, T., Hakomori, S. J. Biol. Chem. (1990)
- Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. Morley, G.E., Vaidya, D., Samie, F.H., Lo, C., Delmar, M., Jalife, J. J. Cardiovasc. Electrophysiol. (1999)
- Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Henkemeyer, M., Rossi, D.J., Holmyard, D.P., Puri, M.C., Mbamalu, G., Harpal, K., Shih, T.S., Jacks, T., Pawson, T. Nature (1995)
- The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Tamir, I., Stolpa, J.C., Helgason, C.D., Nakamura, K., Bruhns, P., Daeron, M., Cambier, J.C. Immunity (2000)
- Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. Gugasyan, R., Quilici, C., I, S.T., Grail, D., Verhagen, A.M., Roberts, A., Kitamura, T., Dunn, A.R., Lock, P. J. Cell Biol. (2002)
- Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap. van der Geer, P., Henkemeyer, M., Jacks, T., Pawson, T. Mol. Cell. Biol. (1997)
- c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. Chang, J.H., Gill, S., Settleman, J., Parsons, S.J. J. Cell Biol. (1995)
- Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157. Yang, J.Y., Walicki, J., Michod, D., Dubuis, G., Widmann, C. Mol. Biol. Cell (2005)
- Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. Ott, V.L., Tamir, I., Niki, M., Pandolfi, P.P., Cambier, J.C. J. Immunol. (2002)
- RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Tourrière, H., Gallouzi, I.E., Chebli, K., Capony, J.P., Mouaikel, J., van der Geer, P., Tazi, J. Mol. Cell. Biol. (2001)
- Protein Kinase A-mediated Phosphorylation of Connexin36 in Mouse Retina Results in Decreased Gap Junctional Communication between AII Amacrine Cells. Urschel, S., H??her, T., Schubert, T., Alev, C., S??hl, G., W??rsd??rfer, P., Asahara, T., Dermietzel, R., Weiler, R., Willecke, K. J. Biol. Chem. (2006)
- A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. Montagner, A., Yart, A., Dance, M., Perret, B., Salles, J.P., Raynal, P. J. Biol. Chem. (2005)
- Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts. Haskell, M.D., Nickles, A.L., Agati, J.M., Su, L., Dukes, B.D., Parsons, S.J. J. Cell. Sci. (2001)
- Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Roof, R.W., Haskell, M.D., Dukes, B.D., Sherman, N., Kinter, M., Parsons, S.J. Mol. Cell. Biol. (1998)