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Gene Review

PUM2  -  pumilio RNA-binding family member 2

Homo sapiens

Synonyms: KIAA0235, PUMH2, PUML2, Pumilio homolog 2, Pumilio-2
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Disease relevance of PUM2


High impact information on PUM2


Biological context of PUM2


Anatomical context of PUM2

  • We also show that in men, the NOS1 and PUM2 proteins are particularly abundant in germline stem cells [8].

Associations of PUM2 with chemical compounds

  • This induction of SGs is dependent on the RNA-binding domain and a glutamine-rich region in the N terminus of Pum2 [7].

Enzymatic interactions of PUM2


Other interactions of PUM2

  • Then, we used coimmunoprecipitation to isolate human transcripts specifically bound by PUM2 and DAZL and subsequently identified those that contain NRE-like sequence elements [4].
  • Here, we demonstrate that human BOL forms homodimers and is able to interact with a PUMILIO homolog, PUM2 [5].
  • Interaction of the conserved meiotic regulators, BOULE (BOL) and PUMILIO-2 (PUM2) [5].

Analytical, diagnostic and therapeutic context of PUM2


  1. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Moore, F.L., Jaruzelska, J., Fox, M.S., Urano, J., Firpo, M.T., Turek, P.J., Dorfman, D.M., Pera, R.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation. Padmanabhan, K., Richter, J.D. Genes Dev. (2006) [Pubmed]
  3. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. Scott, R.E., White-Grindley, E., Ruley, H.E., Chesler, E.J., Williams, R.W. J. Cell. Physiol. (2005) [Pubmed]
  4. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. Fox, M., Urano, J., Reijo Pera, R.A. Genomics (2005) [Pubmed]
  5. Interaction of the conserved meiotic regulators, BOULE (BOL) and PUMILIO-2 (PUM2). Urano, J., Fox, M.S., Reijo Pera, R.A. Mol. Reprod. Dev. (2005) [Pubmed]
  6. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. Spassov, D.S., Jurecic, R. Gene (2002) [Pubmed]
  7. Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules. Vessey, J.P., Vaccani, A., Xie, Y., Dahm, R., Karra, D., Kiebler, M.A., Macchi, P. J. Neurosci. (2006) [Pubmed]
  8. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. Jaruzelska, J., Kotecki, M., Kusz, K., Spik, A., Firpo, M., Reijo Pera, R.A. Dev. Genes Evol. (2003) [Pubmed]
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