The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SLC44A1  -  solute carrier family 44 (choline...

Homo sapiens

Synonyms: CD92, CDW92, CDw92, CHTL1, CTL1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SLC44A1

 

High impact information on SLC44A1

  • These results establish a new family of genes for transporter-like proteins in eukaryotes and suggest that one of its members, CTL1, is involved in supplying choline to certain cell types, including a specific subset of cholinergic neurons [4].
  • Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells [5].
  • Furthermore, we found that CDw92 is stably expressed on monocytes, PBLs, and endothelial cells, as we did not yet find modulation of expression by various stimuli on these cells [5].
  • CDw92 is a 70-kDa surface protein broadly expressed on leukocytes and endothelial cells [5].
  • Computational analysis of the CDw92 protein sequence indicates 10 transmembrane domains, three potential N-linked glycosylation sites, and an amino acid stretch in the C-terminal region that is related to the immunoreceptor tyrosine-based inhibitory motif [5].
 

Biological context of SLC44A1

  • We show here that the choline transporter-like (CTL) family is more extensive than initially described with five genes in humans and complex alternative splicing [1].
  • The promoter was TATA-less and driven by a long stretch of GC-rich sequence in accordance with widespread expression of hCTL1 at both mRNA and protein levels [3].
  • The transcription start site of the hCTL1 gene was mapped by 5'-rapid amplification of cDNA ends (RACE), and the presence of two splice variants, hCTL1a and hCTL1b, was investigated using isoform-specific PCR and 3'-RACE [3].
 

Anatomical context of SLC44A1

  • Together, these data suggest a crucial role of the CDw92 protein in the biology and regulation of the function of leukocytes in particular DCs [5].
  • These findings suggest specific roles for CTL1 splice variants in both neuronal and oligodendrocyte physiology [1].
  • CTL2 mRNA and protein are abundantly expressed in human inner ear [2].
  • The KHRI-3 antibody binds to an N-linked carbohydrate on CTL2 and presumably damages the organ of Corti by blocking the transporter function of this molecule [2].
  • The present study investigates choline transport processes and regulation of choline transporter-like protein-1 (CTL1) in human THP-1 monocytic cells and phorbol myristate 13-acetate (PMA)-differentiated macrophages [6].
 

Associations of SLC44A1 with chemical compounds

  • The 68 and 72 kDa molecular forms of inner ear CTL2 are distinguished by sialic acid modification of the carbohydrate [2].
  • CHT1 and CTL1 but not OCT transporters are selectively inhibited with hemicholinium-3 and essentially display characteristics of specialized transporters for targeted choline metabolism [7].
 

Analytical, diagnostic and therapeutic context of SLC44A1

References

  1. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Traiffort, E., Ruat, M., O'Regan, S., Meunier, F.M. J. Neurochem. (2005) [Pubmed]
  2. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. Nair, T.S., Kozma, K.E., Hoefling, N.L., Kommareddi, P.K., Ueda, Y., Gong, T.W., Lomax, M.I., Lansford, C.D., Telian, S.A., Satar, B., Arts, H.A., El-Kashlan, H.K., Berryhill, W.E., Raphael, Y., Carey, T.E. J. Neurosci. (2004) [Pubmed]
  3. Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1. Yuan, Z., Tie, A., Tarnopolsky, M., Bakovic, M. Physiol. Genomics (2006) [Pubmed]
  4. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. O'Regan, S., Traiffort, E., Ruat, M., Cha, N., Compaore, D., Meunier, F.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells. Wille, S., Szekeres, A., Majdic, O., Prager, E., Staffler, G., Stöckl, J., Kunthalert, D., Prieschl, E.E., Baumruker, T., Burtscher, H., Zlabinger, G.J., Knapp, W., Stockinger, H. J. Immunol. (2001) [Pubmed]
  6. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. Fullerton, M.D., Wagner, L., Yuan, Z., Bakovic, M. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  7. Choline transport for phospholipid synthesis. Michel, V., Yuan, Z., Ramsubir, S., Bakovic, M. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
 
WikiGenes - Universities