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Gene Review

Brip1  -  BRCA1 interacting protein C-terminal...

Mus musculus

Synonyms: 3110009N10Rik, 8030460J03Rik, ATP-dependent RNA helicase BRIP1, BACH1, BRCA1-associated C-terminal helicase 1, ...
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Disease relevance of Brip1

  • It has been demonstrated in the preceding report (Bach, M. A., Beckmann, E. and Levitt, D., Eur. J. Immunol. 1984. 14: 589) that phosphorylcholine (PC) on the bacterium Streptococcus pneumoniae R36a stimulated polyclonal as well as anti-PC plaque-forming cells (PFC) in mouse spleen in vivo [1].

High impact information on Brip1

  • The up-regulated phagocytic activity and reduced SMC proliferation of bach1-deficient cells were not restored by Zinc (II) protoporphyrin IX, an inhibitor of HO, suggesting that HO-independent mechanisms are also involved in the regulation of phagocytosis of macrophages and proliferation of SMC by Bach1 [2].
  • We isolated peritoneal macrophages and aortic smooth muscle cells (SMC) from wild-type and bach1-deficient mice. bach1-Deficient macrophages expressed increased levels of HO-1 and showed elevated phagocytic activity when incubated with 0.75 microm microspheres [2].
  • Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury [2].
  • In SMC, bach1-ablation resulted in increased expression of HO-1 and decreased proliferation in bromodeoxyuridine incorporation assay as compared with wild-type cells [2].
  • In wild-type mice, cuff placement around femoral artery caused pronounced intimal proliferation without affecting the media, thus resulting in intimal to medial (I/M) volume ratio of 65.6%. bach1-deficient mice had less degree of intimal growth (I/M ratio of 45.6%) [2].

Biological context of Brip1

  • To study the gene function, we expressed the mouse BACH gene in C3H 10T1/2 fibroblastic cells using a mifepristone (RU486)-inducible gene expression system [3].
  • Stimulation in mixed lymphocyte culture reaction (MLR) or graft vs host reaction has been shown to be governed by genes located in the I-region (immune response region) of the H-2 complex in mice (Bach et al. 1972 and Klein and Park 1973) and it appears that the H-2K and H-2D regions play only a minor role in that reaction [4].

Anatomical context of Brip1

  • Our results indicate that LTC4 synthetase from mouse peritoneal macrophages is a particulate or membrane-bound enzyme, as was reported by Bach et al.(ABSTRACT TRUNCATED AT 400 WORDS)[5]


  1. Phosphorylcholine on isologous red blood cells induces polyclonal but not anti-phosphorylcholine plaque-forming cells in mice. Beckmann, E., Bach, M.A., Levitt, D. Eur. J. Immunol. (1984) [Pubmed]
  2. Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury. Omura, S., Suzuki, H., Toyofuku, M., Ozono, R., Kohno, N., Igarashi, K. Genes Cells (2005) [Pubmed]
  3. Inducible expression of long-chain acyl-CoA hydrolase gene in cell cultures. Takagi, M., Yamakawa, H., Watanabe, T., Suga, T., Junji, Y. Mol. Cell. Biochem. (2003) [Pubmed]
  4. Effect of anti-Ia sera on mixed lymphocyte reaction in mice. Götze, D., Grosse-Wilde, H., Netzel, B. Folia Biol. (Praha) (1975) [Pubmed]
  5. Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells. Abe, M., Hugli, T.E. Biochim. Biophys. Acta (1988) [Pubmed]
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