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Gene Review

Hmox1  -  heme oxygenase (decycling) 1

Mus musculus

Synonyms: D8Wsu38e, HO-1, HO1, Heme oxygenase 1, Hemox, ...
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Disease relevance of Hmox1


Psychiatry related information on Hmox1


High impact information on Hmox1


Chemical compound and disease context of Hmox1


Biological context of Hmox1


Anatomical context of Hmox1

  • Similarly, the right ventricles were more dilated in HO-1(-/-) mice [1].
  • Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2 [23].
  • Relevantly, ACTH and MTII incubation with primary peritoneal macrophages (Mphi) also induced HO-1 expression [24].
  • Incubation of mouse embryonic fibroblasts with APG (5--40 microM) decreased hemin-induced HO-1 protein and mRNA expression [25].
  • These roles for HO-1 and HO-2 were confirmed using detergent ablation of the epithelium to observe increased neurogenesis of ORNs after target disruption in HO null mice [26].

Associations of Hmox1 with chemical compounds


Physical interactions of Hmox1


Enzymatic interactions of Hmox1


Regulatory relationships of Hmox1

  • MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates [34].
  • Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts [35].
  • The presence of the HO-1 inhibitor did not alter the 15d-PGJ(2)-induced inhibition of LPS-stimulated iNOS and TNFalpha protein levels, and led to only a partial reduction in the protection offered by 15d-PGJ(2) against LPS-induced nitrite production [36].
  • HO-1 expression was significantly inhibited in the liver of TLR4 mutant mice [37].
  • While the liver HO-1 expression in TNF KO mice was much lower than that in C57 mice following the same LPS treatment, IL-1beta KO had a slight influence on liver HO-1 expression following LPS treatment [37].

Other interactions of Hmox1


Analytical, diagnostic and therapeutic context of Hmox1


  1. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. Yet, S.F., Perrella, M.A., Layne, M.D., Hsieh, C.M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., Lee, M.E. J. Clin. Invest. (1999) [Pubmed]
  2. Influence of heme oxygenase 1 modulation on the progression of murine collagen-induced arthritis. Devesa, I., Ferrándiz, M.L., Terencio, M.C., Joosten, L.A., van den Berg, W.B., Alcaraz, M.J. Arthritis Rheum. (2005) [Pubmed]
  3. Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Zhang, X., Bedard, E.L., Potter, R., Zhong, R., Alam, J., Choi, A.M., Lee, P.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  4. Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia. Henningsson, R., Alm, P., Lundquist, I. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  5. Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. Chung, S.W., Liu, X., Macias, A.A., Baron, R.M., Perrella, M.A. J. Clin. Invest. (2008) [Pubmed]
  6. Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms? Panahian, N., Maines, M.D. J. Neurochem. (2001) [Pubmed]
  7. Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining. Maines, M.D., Polevoda, B., Coban, T., Johnson, K., Stoliar, S., Huang, T.J., Panahian, N., Cory-Slechta, D.A., McCoubrey, W.K. J. Neurochem. (1998) [Pubmed]
  8. Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse. Gordon, J.A., Stryker, M.P. J. Neurosci. (1996) [Pubmed]
  9. Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1. Zhang, W., Contag, P.R., Hardy, J., Zhao, H., Vreman, H.J., Hajdena-Dawson, M., Wong, R.J., Stevenson, D.K., Contag, C.H. J. Mol. Med. (2002) [Pubmed]
  10. Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1. Morgan, D., Holcomb, L., Saad, I., Gordon, M., Mahin Maines, n.u.l.l. Brain Res. (1998) [Pubmed]
  11. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Otterbein, L.E., Zuckerbraun, B.S., Haga, M., Liu, F., Song, R., Usheva, A., Stachulak, C., Bodyak, N., Smith, R.N., Csizmadia, E., Tyagi, S., Akamatsu, Y., Flavell, R.J., Billiar, T.R., Tzeng, E., Bach, F.H., Choi, A.M., Soares, M.P. Nat. Med. (2003) [Pubmed]
  12. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Fujita, T., Toda, K., Karimova, A., Yan, S.F., Naka, Y., Yet, S.F., Pinsky, D.J. Nat. Med. (2001) [Pubmed]
  13. Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Burnett, A.L., Johns, D.G., Kriegsfeld, L.J., Klein, S.L., Calvin, D.C., Demas, G.E., Schramm, L.P., Tonegawa, S., Nelson, R.J., Snyder, S.H., Poss, K.D. Nat. Med. (1998) [Pubmed]
  14. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Hancock, W.W., Buelow, R., Sayegh, M.H., Turka, L.A. Nat. Med. (1998) [Pubmed]
  15. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Soares, M.P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S.T., Colvin, R.B., Choi, A.M., Poss, K.D., Bach, F.H. Nat. Med. (1998) [Pubmed]
  16. Gliotoxin reduces the severity of trinitrobenzene sulfonic acid-induced colitis in mice: evidence of the connection between heme oxygenase-1 and the nuclear factor-kappaB pathway in vitro and in vivo. Jun, C.D., Kim, Y., Choi, E.Y., Kim, M., Park, B., Youn, B., Yu, K., Choi, K.S., Yoon, K.H., Choi, S.C., Lee, M.S., Park, K.I., Choi, M., Chung, Y., Oh, J. Inflamm. Bowel Dis. (2006) [Pubmed]
  17. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells. Harrison, E.M., McNally, S.J., Devey, L., Garden, O.J., Ross, J.A., Wigmore, S.J. FEBS J. (2006) [Pubmed]
  18. Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice. Inoue, S., Suzuki, M., Nagashima, Y., Suzuki, S., Hashiba, T., Tsuburai, T., Ikehara, K., Matsuse, T., Ishigatsubo, Y. Hum. Gene Ther. (2001) [Pubmed]
  19. Heme oxygenase-1 protects brain from acute excitotoxicity. Ahmad, A.S., Zhuang, H., Doré, S. Neuroscience (2006) [Pubmed]
  20. Oxidative stress in the brain at early preclinical stages of mouse scrapie. Yun, S.W., Gerlach, M., Riederer, P., Klein, M.A. Exp. Neurol. (2006) [Pubmed]
  21. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. Seroussi, E., Kedra, D., Kost-Alimova, M., Sandberg-Nordqvist, A.C., Fransson, I., Jacobs, J.F., Fu, Y., Pan, H.Q., Roe, B.A., Imreh, S., Dumanski, J.P. Genomics (1999) [Pubmed]
  22. Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase. Minamoto, K., Harada, H., Lama, V.N., Fedarau, M.A., Pinsky, D.J. J. Exp. Med. (2005) [Pubmed]
  23. Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. Lee, T.S., Tsai, H.L., Chau, L.Y. J. Biol. Chem. (2003) [Pubmed]
  24. In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. Lam, C.W., Getting, S.J., Perretti, M. J. Immunol. (2005) [Pubmed]
  25. Apigenin decreases hemin-mediated heme oxygenase-1 induction. Abate, A., Yang, G., Wong, R.J., Schroder, H., Stevenson, D.K., Dennery, P.A. Free Radic. Biol. Med. (2005) [Pubmed]
  26. Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively. Chen, J., Tu, Y., Moon, C., Nagata, E., Ronnett, G.V. J. Neurochem. (2003) [Pubmed]
  27. Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum. Qu, Y., Chen, J., Benvenisti-Zarom, L., Ma, X., Regan, R.F. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  28. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Oh, G.S., Pae, H.O., Lee, B.S., Kim, B.N., Kim, J.M., Kim, H.R., Jeon, S.B., Jeon, W.K., Chae, H.J., Chung, H.T. Free Radic. Biol. Med. (2006) [Pubmed]
  29. Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. Lin, Q., Weis, S., Yang, G., Weng, Y.H., Helston, R., Rish, K., Smith, A., Bordner, J., Polte, T., Gaunitz, F., Dennery, P.A. J. Biol. Chem. (2007) [Pubmed]
  30. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, A., Rodrigues, C.D., Gregoire, I.P., Cunha-Rodrigues, M., Portugal, S., Soares, M.P., Mota, M.M. Nat. Med. (2007) [Pubmed]
  31. Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin. Chung, S.W., Chen, Y.H., Perrella, M.A. J. Biol. Chem. (2005) [Pubmed]
  32. Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. Alam, J., Den, Z. J. Biol. Chem. (1992) [Pubmed]
  33. Tissue-specific changes in heme oxygenase activity and level of nonprotein thiols in C57Bl/6 mice after whole-body gamma-irradiation. Han, Y., Platonov, A.G., Akhalaia, M.Y., Song, J.Y., Ahn, J.Y., Yun, Y.S. Bull. Exp. Biol. Med. (2005) [Pubmed]
  34. MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates. Pittock, S.T., Norby, S.M., Grande, J.P., Croatt, A.J., Bren, G.D., Badley, A.D., Caplice, N.M., Griffin, M.D., Nath, K.A. Kidney Int. (2005) [Pubmed]
  35. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. Petrache, I., Otterbein, L.E., Alam, J., Wiegand, G.W., Choi, A.M. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  36. Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Koppal, T., Petrova, T.V., Van Eldik, L.J. Brain Res. (2000) [Pubmed]
  37. TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta. Song, Y., Shi, Y., Ao, L.H., Harken, A.H., Meng, X.Z. World J. Gastroenterol. (2003) [Pubmed]
  38. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Shen, X.D., Ke, B., Zhai, Y., Gao, F., Anselmo, D., Lassman, C.R., Busuttil, R.W., Kupiec-Weglinski, J.W. Hepatology (2003) [Pubmed]
  39. Macrophage-derived heme-oxygenase-1: expression, regulation, and possible functions in skin repair. Kämpfer, H., Kolb, N., Manderscheid, M., Wetzler, C., Pfeilschifter, J., Frank, S. Mol. Med. (2001) [Pubmed]
  40. Expression and regulation of heme oxygenase isozymes in the developing mouse cortex. Zhao, H., Wong, R.J., Nguyen, X., Kalish, F., Mizobuchi, M., Vreman, H.J., Stevenson, D.K., Contag, C.H. Pediatr. Res. (2006) [Pubmed]
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