Disease relevance of Klk7_predicted

• 4 During pancreatitis, t-KK-like and plasma kallikrein (p-KK)-like activity in the pancreas, as well as trypsinogen activation peptide (TAP) increased significantly [1].
• Application of adenovirus-mediated systemic expression of the tissue kallikrein gene may provide a unique way of delivering the gene product into the vasculature and could have important therapeutic implications in treating hypertension [2].
• During the course of chromate-induced acute renal failure (ARF), urinary kallikrein excretion (UKE), a serine protease of distal tubule origin in the normal animal was decreased but tissue kallikrein concentration (TK) was increased, suggesting intracellular accumulation [3].

High impact information on Klk7_predicted

• Tissue kallikrein-binding protein reduces blood pressure in transgenic mice [4].
• Tissue kallikrein mRNA levels were higher in the kidney of adult female rats, whereas no sex difference was detected in the heart [5].
• Northern blot analyses using specific oligonucleotide probes demonstrate that, among the 12 tissues studied, RSKG-7 and RSKG-3 are expressed in the rat kidney and submandibular gland [6].
• RSKG-7 is approximately 4200 bases in length and consists of five exons and four introns [6].
• On immunoelectrophoresis against kallikrein antisera, esterase B formed a precipitin arc at a position different from that of kallikrein [7].

Biological context of Klk7_predicted

• The stage-dependent specific expression of tK and bradykinin B2Rs in developing germ cells and peritubular cells suggests a potential role of the tKKS in the local regulation of spermatogenesis and seminiferous tubule function [8].
• These proteinases correspond to the products of the RSKG-7 and the rGK8 genes, as shown by the comparison of their partial amino-acid sequence with that deduced from nucleotide sequences [9].
• 1. Tissue kallikrein is overexpressed in the kidney of female rats, this sexual dimorphism being associated with a greater effect of early blockade of bradykinin B2-receptors on female blood pressure phenotype [10].
• Porcine tissue kallikrein shows very extensive sequence homology with several enzymes from submandibular glands of rats and mice, tonin, nerve growth factor gamma subunit, and submandibular proteinase A, nearly as high as with human urinary or rat submandibular kallikrein [11].

Anatomical context of Klk7_predicted

• It was therefore concluded that like tonin and antigen gamma, but unlike kallikrein, esterase B was not detected in the striated ducts of the submandibular, parotid, or sublingual glands [12].
• In the epididymis, tK was detected on epithelial cells near the apical surface [8].
• In the testis, specific staining for tK occurred in addition to endothelial cells of blood vessels on the acrosomal cap of round and elongated spermatids [8].
• Castration of male rats results in a decrease in submandibular gland RSKG-7 mRNA, which can be restored to the normal level by treatment with thyroxine or testosterone [6].
• Esterase B, however, is only a weak kininogenase, since it had only 5% of the kininogenase activity of equimolar concentrations of glandular kallikrein and had no effect on rat mean blood pressure or on the isolated rat uterus [7].

Associations of Klk7_predicted with chemical compounds

• Icatibant pretreatment further augmented t-KK about 100-fold, while p-KK was significantly attenuated; TAP levels remained unaffected [1].
• Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat [8].
• Immunohistochemical localization of rat submandibular gland esterase B (homologous to the RSKG-7 kallikrein gene) in relation to other serine proteases of the kallikrein family [12].
• 5. Esterase B hydrolyzed the synthetic substrates tosyl-L-arginine methyl ester and Val-Leu-Arg-p-nitroanilide (S2266) [7].
• To characterize the role of the kallikrein-kinin system in diabetic cardiopathy, we studied the effect of streptozotocin (STZ) on the regulation of the myocardial bradykinin (BK) receptors, the B1 and B2 type, and two tissue kallikrein genes, rat kallikrein 1 (rKLK1) and rKLK7, in severely hyperglycemic rats [13].

Regulatory relationships of Klk7_predicted

• Esterase B-like enzyme activated rat urinary prokallikrein better than tonin [14].
• Esterase B activated plasminogen and had caseinolytic activity [7].

Other interactions of Klk7_predicted

• Proteinase A with Mr of 28,200 rapidly cleaved high-molecular-weight (HMW) kininogen into a protein of 67 kDa, which retained thiol-proteinase inhibitory activity, but had lost the correcting activity of HMW kininogen on the prolonged clotting time of Fitzgerald trait plasma [15].
• Esterase B appears to be a trypsin-like serine protease having some homology with glandular kallikrein [7].

Analytical, diagnostic and therapeutic context of Klk7_predicted

• On the other hand, neither castration nor hormonal manipulation affects RSKG-7 mRNA levels in the kidney [6].
• Rapid purification of tonin, esterase B, antigen psi and kallikrein from rat submandibular gland by fast protein liquid chromatography [16].

References