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Gene Review

KLK7  -  kallikrein-related peptidase 7

Homo sapiens

Synonyms: Kallikrein-7, PRSS6, SCCE, Serine protease 6, Stratum corneum chymotryptic enzyme, ...
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Disease relevance of KLK7

  • Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers [1].
  • KLK7 status also correlated with size of residual tumor postsurgery [2].
  • This subgroup was least influenced by postoperative treatment and thus best showed the impact of KLK7 expression on the natural course of breast cancer disease [3].
  • KLK5 expression is significantly more expressed in squamous cell carcinoma than in matched nonmalignant lung tissue (P=0.02), whereas expression of KLK7 was decreased in adenocarcinoma (P=0.003) [4].
  • KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer [4].

High impact information on KLK7

  • Two members of the human tissue kallikrein (KLK) family of (chymo)tryptic-like serine proteases, KLK5 and KLK7, are implicated in desquamation by digestion of (corneo)desmosomes and inhibition by desquamation-related serine protease inhibitors (SPIs) [5].
  • The extended substrate specificity profiles are in good agreement with known substrate cleavage sites but also in accord with experimentally solved (hK4, hK6, and hK7) or modeled structures [6].
  • The stratum corneum chymotryptic enzyme (SCCE) has been previously purified from human stratum corneum and resembles a chymotryptic serine endopeptidase involved in physiological detachment of corneocytes from human stratum corneum [7].
  • Thus, antileukoprotease, which is known to be produced by human keratinocytes, is likely to be the major physiological inhibitor of SCCE in the epidermis [7].
  • Tryptic digestion removed this propeptide and yielded a proteolytically active protein with the same NH2-terminal amino acid sequence as native SCCE [8].

Chemical compound and disease context of KLK7


Biological context of KLK7


Anatomical context of KLK7


Associations of KLK7 with chemical compounds

  • In contrast to involucrin, which was expressed by all suprabasal keratinocytes, SCCE was expressed only by high suprabasal cells [16].
  • In order to investigate the mechanism of glycolic acid (GA) function in human stratum corneum, we monitored changes in cathepsin D-like (CD) and chymotrypsin-like (SCCE) proteinases for 3 weeks following topical GA application (50% w/v, pH 0.9) for 30 min to human skin [17].
  • Expression of stratum corneum chymotryptic enzyme in reconstructed human epidermis and its suppression by retinoic acid [18].
  • We found expression of SCCE in luminal parts of the pilary canal, common sebaceous ducts and proximal sebaceous ducts [19].

Enzymatic interactions of KLK7


Regulatory relationships of KLK7


Other interactions of KLK7

  • Using the recombinant form of CDSN, either with its N-glycan chain or enzymatically deglycosylated, we also demonstrated that oligosaccharide residues do not protect CDSN against proteolysis by SCCE [21].
  • This was in spite of very low levels of KLK14 protein compared to KLK5 and KLK7 [22].
  • In this study, we examined the level of mRNA expression of the KLK7 and KLK8 genes in 73 intracranial tumors using qualitative RT-PCR [11].
  • Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer [3].
  • OBJECTIVE: To determine whether the Stratum Corneum Chymotryptic Enzyme (SCCE), a novel serine protease known to contribute to the cell shedding process by catalyzing the degradation of intercellular cohesive structures at the skin surface, is overexpressed in human cervical tumors [23].

Analytical, diagnostic and therapeutic context of KLK7


  1. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. Dong, Y., Kaushal, A., Brattsand, M., Nicklin, J., Clements, J.A. Clin. Cancer Res. (2003) [Pubmed]
  2. Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer. Kyriakopoulou, L.G., Yousef, G.M., Scorilas, A., Katsaros, D., Massobrio, M., Fracchioli, S., Diamandis, E.P. Clin. Biochem. (2003) [Pubmed]
  3. Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer. Holzscheiter, L., Biermann, J.C., Kotzsch, M., Prezas, P., Farthmann, J., Baretton, G., Luther, T., Tjan-Heijnen, V.C., Talieri, M., Schmitt, M., Sweep, F.C., Span, P.N., Magdolen, V. Clin. Chem. (2006) [Pubmed]
  4. KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer. Planque, C., de Monte, M., Guyetant, S., Rollin, J., Desmazes, C., Panel, V., Lemarié, E., Courty, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  5. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. Borgoño, C.A., Michael, I.P., Komatsu, N., Jayakumar, A., Kapadia, R., Clayman, G.L., Sotiropoulou, G., Diamandis, E.P. J. Biol. Chem. (2007) [Pubmed]
  6. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. Debela, M., Magdolen, V., Schechter, N., Valachova, M., Lottspeich, F., Craik, C.S., Choe, Y., Bode, W., Goettig, P. J. Biol. Chem. (2006) [Pubmed]
  7. Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation. Franzke, C.W., Baici, A., Bartels, J., Christophers, E., Wiedow, O. J. Biol. Chem. (1996) [Pubmed]
  8. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A., Egelrud, T. J. Biol. Chem. (1994) [Pubmed]
  9. Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. Talieri, M., Diamandis, E.P., Gourgiotis, D., Mathioudaki, K., Scorilas, A. Thromb. Haemost. (2004) [Pubmed]
  10. The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation. Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A., Diamandis, E.P. Gene (2000) [Pubmed]
  11. The role of human tissue kallikreins 7 and 8 in intracranial malignancies. Prezas, P., Scorilas, A., Yfanti, C., Viktorov, P., Agnanti, N., Diamandis, E., Talieri, M. Biol. Chem. (2006) [Pubmed]
  12. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. Cork, M.J., Robinson, D.A., Vasilopoulos, Y., Ferguson, A., Moustafa, M., MacGowan, A., Duff, G.W., Ward, S.J., Tazi-Ahnini, R. J. Allergy Clin. Immunol. (2006) [Pubmed]
  13. LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. Ishida-Yamamoto, A., Deraison, C., Bonnart, C., Bitoun, E., Robinson, R., O'Brien, T.J., Wakamatsu, K., Ohtsubo, S., Takahashi, H., Hashimoto, Y., Dopping-Hepenstal, P.J., McGrath, J.A., Iizuka, H., Richard, G., Hovnanian, A. J. Invest. Dermatol. (2005) [Pubmed]
  14. Epidermal lamellar granules transport different cargoes as distinct aggregates. Ishida-Yamamoto, A., Simon, M., Kishibe, M., Miyauchi, Y., Takahashi, H., Yoshida, S., O'Brien, T.J., Serre, G., Iizuka, H. J. Invest. Dermatol. (2004) [Pubmed]
  15. Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols. Shan, S.J., Scorilas, A., Katsaros, D., Rigault de la Longrais, I., Massobrio, M., Diamandis, E.P. Clin. Chem. (2006) [Pubmed]
  16. Expression of stratum corneum chymotryptic enzyme in relation to other markers of epidermal differentiation in a skin explant model. Ekholm, E., Egelrud, T. Exp. Dermatol. (2000) [Pubmed]
  17. Effects of glycolic acid on desquamation-regulating proteinases in human stratum corneum. Horikoshi, T., Matsumoto, M., Usuki, A., Igarashi, S., Hikima, R., Uchiwa, H., Hayashi, S., Brysk, M.M., Ichihashi, M., Funasaka, Y. Exp. Dermatol. (2005) [Pubmed]
  18. Expression of stratum corneum chymotryptic enzyme in reconstructed human epidermis and its suppression by retinoic acid. Egelrud, T., Régnier, M., Sondell, B., Shroot, B., Schmidt, R. Acta Derm. Venereol. (1993) [Pubmed]
  19. Expression of stratum corneum chymotryptic enzyme in human sebaceous follicles. Ekholm, E., Sondell, B., Strandén, P., Brattsand, M., Egelrud, T. Acta Derm. Venereol. (1998) [Pubmed]
  20. Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro. Nylander-Lundqvist, E., Egelrud, T. Acta Derm. Venereol. (1997) [Pubmed]
  21. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. Caubet, C., Jonca, N., Brattsand, M., Guerrin, M., Bernard, D., Schmidt, R., Egelrud, T., Simon, M., Serre, G. J. Invest. Dermatol. (2004) [Pubmed]
  22. Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum. Stefansson, K., Brattsand, M., Ny, A., Glas, B., Egelrud, T. Biol. Chem. (2006) [Pubmed]
  23. The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells. Santin, A.D., Cane', S., Bellone, S., Bignotti, E., Palmieri, M., De Las Casas, L.E., Roman, J.J., Anfossi, S., O'Brien, T., Pecorelli, S. Gynecol. Oncol. (2004) [Pubmed]
  24. Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process? Ekholm, I.E., Brattsand, M., Egelrud, T. J. Invest. Dermatol. (2000) [Pubmed]
  25. Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J., Tazi-Ahnini, R. J. Invest. Dermatol. (2004) [Pubmed]
  26. Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzyme. Bondurant, K.L., Crew, M.D., Santin, A.D., O'Brien, T.J., Cannon, M.J. Clin. Cancer Res. (2005) [Pubmed]
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