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Gene Review

Slco2a1  -  solute carrier organic anion transporter...

Mus musculus

Synonyms: 2310021C19Rik, Oatp2a1, PGT, Pgt, Prostaglandin transporter, ...
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High impact information on Slco2a1

  • Inhibitors of other channels, such as the purinergic receptor P2X7 and the prostaglandin transporter PGT, had no effect on PGE2 release [1].
  • Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells [2].
  • In the present study, we investigated whether melatonin would prevent nitric oxide (NO)-induced apoptotic death of PGT-beta immortalized pineal cells [2].
  • To identify the cis-acting region responsible for pineal-specific expression of the TPH gene, we investigated a 6.1-kb 5'-flanking region of the mouse TPH gene using an immortalized pineal cell line (PGT-beta) derived from transgenic mice [3].
  • To develop PGT-specific inhibitors with high affinity, we designed a library of triazine compounds and screened 1842 small molecules by using Madin-Darby canine kidney cells stably expressing rat PGT [4].

Biological context of Slco2a1


Anatomical context of Slco2a1


Associations of Slco2a1 with chemical compounds

  • Tyrosine kinase activity was measured by using an exogenous substrate: polyamino acid glutamic acid-tyrosine (4:1) (PGT) [5].

Analytical, diagnostic and therapeutic context of Slco2a1


  1. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Cherian, P.P., Siller-Jackson, A.J., Gu, S., Wang, X., Bonewald, L.F., Sprague, E., Jiang, J.X. Mol. Biol. Cell (2005) [Pubmed]
  2. Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells. Yoo, Y.M., Yim, S.V., Kim, S.S., Jang, H.Y., Lea, H.Z., Hwang, G.C., Kim, J.W., Kim, S.A., Lee, H.J., Kim, C.J., Chung, J.H., Leem, K.H. J. Pineal Res. (2002) [Pubmed]
  3. Identification and sequencing of pineal-specific enhancing region in the mouse tryptophan hydroxylase promoter. Yim, S.V., Huh, S.O., Kim, J.W., Kim, M.J., Park, S.J., Jung, J.C., Chung, J.H. J. Pineal Res. (2000) [Pubmed]
  4. Identification of a new class of prostaglandin transporter inhibitors and characterization of their biological effects on prostaglandin E2 transport. Chi, Y., Khersonsky, S.M., Chang, Y.T., Schuster, V.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  5. Correlation between phosphorylation and kinase activity of a tyrosine protein kinase: p56lck. Boulet, I., Fagard, R., Fischer, S. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  6. Serotonin induces apoptosis in PGT-beta pineal gland tumor cells. Yim, S.V., Kim, K.H., Kim, C.J., Chung, J.H. Jpn. J. Pharmacol. (2000) [Pubmed]
  7. Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells. Suh, B.C., Kim, T.D., Lee, J.U., Seong, J.K., Kim, K.T. Br. J. Pharmacol. (2001) [Pubmed]
  8. Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea. Henry, P.J., D'Aprile, A., Self, G., Hong, T., Mann, T.S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
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