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Gene Review

SLCO2A1  -  solute carrier organic anion transporter...

Homo sapiens

Synonyms: MATR1, OATP2A1, PGT, PHOAR2, Prostaglandin transporter, ...
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Disease relevance of SLCO2A1


High impact information on SLCO2A1

  • The broad tissue distribution and substrate profile of hPGT suggest a role in the transport and/or metabolic clearance of PGs in diverse human tissues [4].
  • Northern blotting revealed mRNA transcripts of many different sizes in adult human heart, placenta, brain, lung, liver, skeletal muscle, pancreas, kidney, spleen, prostate, ovary, small intestine, and colon. hPGT mRNAs are also strongly expressed in human fetal brain, lung, liver, and kidney [4].
  • Because PGs play diverse and important roles in human health and disease, we cloned human PGT (hPGT) from an adult human kidney cDNA library [4].
  • A consensus sequence (4.0 kb) derived from several clones, plus 3' polymerase chain reaction amplification, exhibited 74% nucleic acid identity and 82% amino acid identity compared to rat PGT [4].
  • In cells expressing the prostaglandin transporter PGT, the steady-state accumulation of PGE1 and PGE2 was reduced proportional to MRP4 expression [5].

Chemical compound and disease context of SLCO2A1


Biological context of SLCO2A1


Anatomical context of SLCO2A1


Associations of SLCO2A1 with chemical compounds


Other interactions of SLCO2A1

  • Various biochemical stimuli, such as bacterial endotoxin and the inflammatory cytokines recombinant human interleukin 1beta cytokines (rhIL-1beta) and tumor necrosis factor-alpha (TNF-alpha), did not significantly induce hPGT [8].

Analytical, diagnostic and therapeutic context of SLCO2A1

  • A large increase in hPGT mRNA level, as measured by real-time PCR analysis, was observed in decidual cells compared with control [7].
  • Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization [9].
  • Quantitative RT-PCR showed human PGT (hPGT) expression to be strong in the proliferative and early secretory phases and low in the middle to late secretory phase [13].
  • Endometrial biopsies collected across the menstrual cycle were used to assess hPGT protein expression by immunohistochemistry. hPGT was immunolocalized to luminal, glandular epithelial, and stromal cells [13].
  • RMICs expressed endogenous PGT as assessed by mRNA and immunoblotting [14].


  1. Phase III trial of cisplatin/gemcitabine with or without vinorelbine or paclitaxel in advanced non-small cell lung cancer. Comella, P. Semin. Oncol. (2001) [Pubmed]
  2. Renal glucose transport after kidney transplantation. Secchi, A., Hadj-Aissa, A., Pozet, N., Touraine, J.L., Pozza, G., Dubernard, J.M., Traeger, J. Eur. J. Clin. Invest. (1984) [Pubmed]
  3. Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10. Van Der Zwaag, B., Verzijl, H.T., Beltran-Valero De Bernabe, D., Schuster, V.L., Van Bokhoven, H., Kremer, H., Van Reen, M., Wichers, G.H., Brunner, H.G., Padberg, G.W. J. Med. Genet. (2002) [Pubmed]
  4. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). Lu, R., Kanai, N., Bao, Y., Schuster, V.L. J. Clin. Invest. (1996) [Pubmed]
  5. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Reid, G., Wielinga, P., Zelcer, N., van der Heijden, I., Kuil, A., de Haas, M., Wijnholds, J., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Interim analysis of a phase III trial. Triple- vs double-agent chemotherapy for advanced non-small-cell lung cancer. Southern Italy Cooperative Oncology Group. Comella, P. Oncology (Williston Park, N.Y.) (2000) [Pubmed]
  7. Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells. Kang, J., Chapdelaine, P., Laberge, P.Y., Fortier, M.A. Hum. Reprod. (2006) [Pubmed]
  8. Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo. Topper, J.N., Cai, J., Stavrakis, G., Anderson, K.R., Woolf, E.A., Sampson, B.A., Schoen, F.J., Falb, D., Gimbrone, M.A. Circulation (1998) [Pubmed]
  9. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. Lu, R., Schuster, V.L. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  10. Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT". Chan, B.S., Satriano, J.A., Pucci, M., Schuster, V.L. J. Biol. Chem. (1998) [Pubmed]
  11. Mapping the substrate binding site of the prostaglandin transporter PGT by cysteine scanning mutagenesis. Chan, B.S., Satriano, J.A., Schuster, V.L. J. Biol. Chem. (1999) [Pubmed]
  12. Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport. Vezza, R., Rokach, J., FitzGerald, G.A. Mol. Pharmacol. (2001) [Pubmed]
  13. Expression of human prostaglandin transporter in the human endometrium across the menstrual cycle. Kang, J., Chapdelaine, P., Parent, J., Madore, E., Laberge, P.Y., Fortier, M.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  14. Coordinate control of prostaglandin E2 synthesis and uptake by hyperosmolarity in renal medullary interstitial cells. Pucci, M.L., Endo, S., Nomura, T., Lu, R., Khine, C., Chan, B.S., Bao, Y., Schuster, V.L. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
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