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Gene Review

pgr1  -  mitochondrial glutathione reductase Pgr1

Schizosaccharomyces pombe 972h-

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High impact information on SPBC17A3.07


Biological context of SPBC17A3.07


Associations of SPBC17A3.07 with chemical compounds

  • Repression of nmt1 promoter-driven pgr1(+) expression by thiamine caused cessation of growth, which was rescued by the episomal pgr1(+) gene [1].
  • We also show the inactivation of glutathione reductase (GR) and glutathione peroxidase in the presence of various reactive nitrogen species in vivo [5].
  • Effect of nitrosative stress on Schizosaccharomyces pombe: inactivation of glutathione reductase by peroxynitrite [5].
  • The presence of 0.2 mM H2O2 induced catalase by 2.8-fold and peroxidase by 2.0-fold The presence of 0.2 mM MD induced catalase by 2.0-fold, glucose-6-phosphate dehydrogenase by 1.9-fold, glutathione reductase by 2.7-fold, peroxidase by 3.0-fold, and superoxide dismutase (SOD) by 2.1-fold [6].
  • These data strongly suggested that, instead of GSH, the NADPH/GR system was the major one-electron Cr(VI) reductant in vivo [7].

Analytical, diagnostic and therapeutic context of SPBC17A3.07


  1. Isolation, expression, and regulation of the pgr1(+) gene encoding glutathione reductase absolutely required for the growth of Schizosaccharomyces pombe. Lee, J., Dawes, I.W., Roe, J.H. J. Biol. Chem. (1997) [Pubmed]
  2. Chromate tolerance caused by reduced hydroxyl radical production and decreased glutathione reductase activity in Schizosaccharomyces pombe. Gazdag, Z., Pócsi, I., Belágyi, J., Emri, T., Blaskó, A., Takács, K., Pesti, M. J. Basic Microbiol. (2003) [Pubmed]
  3. Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Song, J.Y., Cha, J., Lee, J., Roe, J.H. Eukaryotic Cell (2006) [Pubmed]
  4. Fission yeast dihydrolipoamide dehydrogenase gene is involved in G1/S cell cycle progression. Jang, Y.J., Chung, K.S., Park, C., Yoo, H.S. Biochim. Biophys. Acta (1997) [Pubmed]
  5. Effect of nitrosative stress on Schizosaccharomyces pombe: inactivation of glutathione reductase by peroxynitrite. Sahoo, R., Dutta, T., Das, A., Sinha Ray, S., Sengupta, R., Ghosh, S. Free Radic. Biol. Med. (2006) [Pubmed]
  6. Adaptive response of Schizosaccharomyces pombe to hydrogen peroxide and menadione. Lee, J., Dawes, I.W., Roe, J.H. Microbiology (Reading, Engl.) (1995) [Pubmed]
  7. Chromate sensitivity in fission yeast is caused by increased glutathione reductase activity and peroxide overproduction. Pesti, M., Gazdag, Z., Emri, T., Farkas, N., Koósz, Z., Belágyi, J., Pócsi, I. J. Basic Microbiol. (2002) [Pubmed]
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