Gene Review:
Otx2 - orthodenticle homolog 2
Mus musculus
Synonyms:
E130306E05Rik, Homeobox protein OTX2, Orthodenticle homolog 2, Otx-2
- Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Boyl, P.P., Signore, M., Acampora, D., Martinez-Barbera, J.P., Ilengo, C., Annino, A., Corte, G., Simeone, A. Development (2001)
- Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., Brûlet, P. Development (1995)
- The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Baas, D., Bumsted, K.M., Martinez, J.A., Vaccarino, F.M., Wikler, K.C., Barnstable, C.J. Brain Res. Mol. Brain Res. (2000)
- The caudal limit of Otx2 expression positions the isthmic organizer. Broccoli, V., Boncinelli, E., Wurst, W. Nature (1999)
- A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. Millet, S., Campbell, K., Epstein, D.J., Losos, K., Harris, E., Joyner, A.L. Nature (1999)
- Otx genes are required for tissue specification in the developing eye. Martinez-Morales, J.R., Signore, M., Acampora, D., Simeone, A., Bovolenta, P. Development (2001)
- Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain. Rhinn, M., Dierich, A., Le Meur, M., Ang, S. Development (1999)
- Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. Zhang, Y., Miki, T., Iwanaga, T., Koseki, Y., Okuno, M., Sunaga, Y., Ozaki, N., Yano, H., Koseki, H., Seino, S. J. Biol. Chem. (2002)
- Nested expression domains of four homeobox genes in developing rostral brain. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A., Boncinelli, E. Nature (1992)
- Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Rhinn, M., Dierich, A., Shawlot, W., Behringer, R.R., Le Meur, M., Ang, S.L. Development (1998)
- Genetic control of brain morphogenesis through Otx gene dosage requirement. Acampora, D., Avantaggiato, V., Tuorto, F., Simeone, A. Development (1997)
- Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Puelles, E., Annino, A., Tuorto, F., Usiello, A., Acampora, D., Czerny, T., Brodski, C., Ang, S.L., Wurst, W., Simeone, A. Development (2004)
- Emx and Otx homeobox genes in the developing mouse brain. Boncinelli, E., Gulisano, M., Broccoli, V. J. Neurobiol. (1993)
- Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. Li, J.Y., Joyner, A.L. Development (2001)
- Involvement of Pax6 and Otx2 in the forebrain-specific regulation of the vertebrate homeobox gene ANF/Hesx1. Spieler, D., Bäumer, N., Stebler, J., Köprunner, M., Reichman-Fried, M., Teichmann, U., Raz, E., Kessel, M., Wittler, L. Dev. Biol. (2004)
- Retinoic acid induces a tissue-specific deletion in the expression domain of Otx2. Clotman, F., Van Maele-Fabry, G., Picard, J.J. Neurotoxicology and teratology. (1997)
- The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Kelley, C.G., Lavorgna, G., Clark, M.E., Boncinelli, E., Mellon, P.L. Mol. Endocrinol. (2000)
- EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Liu, A., Joyner, A.L. Development (2001)
- Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Li, J.Y., Lao, Z., Joyner, A.L. Neuron (2002)
- Functional analysis of transcriptional repressor Otx3/Dmbx1. Kimura, K., Miki, T., Shibasaki, T., Zhang, Y., Ogawa, M., Saisho, H., Okuno, M., Iwanaga, T., Seino, S. FEBS Lett. (2005)
- The mouse homeodomain protein OTX2 regulates NCAM promoter activity. Nguyen Ba-Charvet, K.T., von Boxberg, Y., Godement, P. Brain Res. Mol. Brain Res. (1999)
- FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Liu, A., Losos, K., Joyner, A.L. Development (1999)
- Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Guo, C., Qiu, H.Y., Huang, Y., Chen, H., Yang, R.Q., Chen, S.D., Johnson, R.L., Chen, Z.F., Ding, Y.Q. Development (2007)
- Expression of murine Lhx5 suggests a role in specifying the forebrain. Sheng, H.Z., Bertuzzi, S., Chiang, C., Shawlot, W., Taira, M., Dawid, I., Westphal, H. Dev. Dyn. (1997)
- Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Omodei, D., Acampora, D., Mancuso, P., Prakash, N., Di Giovannantonio, L.G., Wurst, W., Simeone, A. Development (2008)
- A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain. Nguyen Ba-Charvet, K.T., von Boxberg, Y., Guazzi, S., Boncinelli, E., Godement, P. Development (1998)
- The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts. Millet, S., Bloch-Gallego, E., Simeone, A., Alvarado-Mallart, R.M. Development (1996)
- New Otx2 mRNA isoforms expressed in the mouse brain. Courtois, V., Chatelain, G., Han, Z.Y., Le Novère, N., Brun, G., Lamonerie, T. J. Neurochem. (2003)
- Spatial and temporal 'knock down' of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos. Mellitzer, G., Hallonet, M., Chen, L., Ang, S.L. Mech. Dev. (2002)