The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GCSH  -  glycine cleavage system protein H...

Homo sapiens

Synonyms: GCE, Glycine cleavage system H protein, mitochondrial, Lipoic acid-containing protein, NKH
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GCSH


High impact information on GCSH

  • Heterozygous GLDC and GCSH gene mutations in transient neonatal hyperglycinemia [2].
  • Gene Symbol: GLDC. Disease: NKH glycine encephalopathy [3].
  • The interaction between anticancer herbal drug emodin and DNA was studied with differential pulse voltammetry (DPV) and cyclic voltammetry (CV) at the bare or DNA modified GCE and ultraviolet-visible (UV) spectra [4].
  • GCSH was expressed in all 29 tissues examined, while T-protein mRNA was detected in 27 of the 29 tissues [1].
  • Using the PAC clone as a probe, we mapped GCSH to chromosome 16q24 by fluorescence in situ hybridization [1].

Biological context of GCSH

  • GCSH spanned 13.5kb and consisted of five exons [1].
  • To facilitate the mutational and functional analyses of GCSH, we isolated and characterized a human p1-derived artificial chromosome (PAC) clone encoding GCSH [1].
  • The experiments have clearly proven that OTA interacts and binds to dsDNA strands immobilized onto a GCE surface, but no evidence of DNA-damage caused by OTA was obtained [5].
  • Furthermore, acute intravenous administrations of GCE (50-800 mg/kg iv) produced dose-dependent, significant reductions (p < 0.05-0.001) in systemic arterial blood pressure and heart rates of the normotensive and hypertensive rats used [6].

Associations of GCSH with chemical compounds

  • NKH is caused by deficiency of the glycine cleavage multi-enzyme system with three specific components encoded by GLDC, AMT, and GCSH [7].
  • On the contrary to that observed at a bare GCE, a good repeatability of the amperometric measurements carried out at +900 mV versus Ag/AgCl (R.S.D. of 3.2% for i(p), n=20) was achieved at the CNTs-GCE [8].
  • Choline can be covalently grafted on glassy carbon electrodes using cyclic voltammetric method, forming a stable cationic monolayer-modified electrode (Ch/GCE) [9].
  • Acute oral administrations of G cupulata aqueous leaf extract (GCE, 50-800 mg/kg po) caused dose-related, significant (p < 0.05-0.001) hypoglycaemia in normal and STZ-treated diabetic rats [6].
  • Nitrite reductase (NiR, nitric-oxide: ferricytochrome c oxidoreductase, EC and methyl viologen (MV) were co-immobilized on glassy carbon electrode (GCE, d=3 mm) by polymer entrapment, and the electrode was tested as an electrochemical biosensor for amperometric determination of nitrite [10].

Other interactions of GCSH


  1. Chromosomal localization, structure, single-nucleotide polymorphisms, and expression of the human H-protein gene of the glycine cleavage system (GCSH), a candidate gene for nonketotic hyperglycinemia. Kure, S., Kojima, K., Kudo, T., Kanno, K., Aoki, Y., Suzuki, Y., Shinka, T., Sakata, Y., Narisawa, K., Matsubara, Y. J. Hum. Genet. (2001) [Pubmed]
  2. Heterozygous GLDC and GCSH gene mutations in transient neonatal hyperglycinemia. Kure, S., Kojima, K., Ichinohe, A., Maeda, T., Kalmanchey, R., Fekete, G., Berg, S.Z., Filiano, J., Aoki, Y., Suzuki, Y., Izumi, T., Matsubara, Y. Ann. Neurol. (2002) [Pubmed]
  3. Gene Symbol: GLDC. Disease: NKH glycine encephalopathy. Toone, J.R., Applegarth, D.A., Laliberte, G. Hum. Genet. (2003) [Pubmed]
  4. Electrochemical studies of the interaction of the anticancer herbal drug emodin with DNA. Wang, L., Lin, L., Ye, B. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  5. Electrochemical oxidation of ochratoxin A at a glassy carbon electrode and in situ evaluation of the interaction with deoxyribonucleic acid using an electrochemical deoxyribonucleic acid-biosensor. Oliveira, S.C., Diculescu, V.C., Palleschi, G., Compagnone, D., Oliveira-Brett, A.M. Anal. Chim. Acta (2007) [Pubmed]
  6. Hypoglycaemic and hypotensive effects of Globimetula cupulata (DC) Van Tieghem (Loranthaceae) aqueous leaf extract in rats. Ojewole, J.A., Adewole, S.O. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners (2007) [Pubmed]
  7. Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia. Kure, S., Kato, K., Dinopoulos, A., Gail, C., DeGrauw, T.J., Christodoulou, J., Bzduch, V., Kalmanchey, R., Fekete, G., Trojovsky, A., Plecko, B., Breningstall, G., Tohyama, J., Aoki, Y., Matsubara, Y. Hum. Mutat. (2006) [Pubmed]
  8. Determination of beta-carboline alkaloids in foods and beverages by high-performance liquid chromatography with electrochemical detection at a glassy carbon electrode modified with carbon nanotubes. Agüí, L., Peña-Farfal, C., Yáñez-Sedeño, P., Pingarrón, J.M. Anal. Chim. Acta (2007) [Pubmed]
  9. Self-assembly of molybdophosphate on a glassy carbon electrode covalently modified with choline and electrocatalytic reduction of iodate. Lin, X., Jiang, C. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2006) [Pubmed]
  10. Electrochemical characterization of biosensor based on nitrite reductase and methyl viologen co-immobilized glassy carbon electrode. Quan, D., Min, D.G., Cha, G.S., Nam, H. Bioelectrochemistry (Amsterdam, Netherlands) (2006) [Pubmed]
WikiGenes - Universities