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Gene Review

MAGEA2B  -  melanoma antigen family A, 2B

Homo sapiens

Synonyms: MAGE2, MAGEA2, MAGEA2b, MGC16973, melanoma antigen family A2B
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Disease relevance of MAGEA2B


High impact information on MAGEA2B

  • All but the MAGE-2 and MAGE-12 nonapeptides efficiently inhibited photoaffinity labeling of HLA-A1, which is in agreement with the known HLA-A1 peptide-binding motif (acidic residue in P3 and C-terminal tyrosine) [6].
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity analysis of both MAGE2 and MAGE6 transfectants demonstrates a 4-fold increase in resistance to paclitaxel and 2-fold increase in resistance to doxorubicin but not to other drugs, such as topotecan and cisplatin, through a nonmultidrug resistance-1 mechanism [4].
  • Identification of a MAGE-2-encoded human leukocyte antigen-A24-binding synthetic peptide that induces specific antitumor cytotoxic T lymphocytes [7].
  • CD8(+) T cells specific for MAGE-2 were not observed [8].
  • Thus, MAGE-2-derived peptides that bind to HLA class I molecules and elicit cytotoxic T lymphocyte (CTL) responses could be of significant therapeutic importance [9].

Biological context of MAGEA2B

  • MAGE 2, 4, 6 and 12 gene expression was not detected in any of the lesions studied [10].
  • Like the open reading frame of MAGE1, that of MAGE2 is entirely encoded by the last exon [2].
  • The complete MAGE2 sequence was obtained and it comprises 3 exons homologous to those of MAGE1 and an additional exon homologous to a region of the first MAGE1 intron [2].
  • Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma [11].
  • Unlike methylated promoters, unmethylated promoters of MAGE2, 3 and 4 genes drove the expression of reporter gene-enhanced green fluorescent protein after transient transfection of cancer-testis antigen-positive Mel 142 melanoma cells [11].

Anatomical context of MAGEA2B

  • No MAGE1 and MAGE2 gene expression was found in a large panel of healthy adult tissues, with the exception of testis [2].
  • Our results demonstrate that MAGE-1, MAGE-2, and MAGE-3 genes are transcribed in primary ocular melanoma cell lines and are detected in cells recovered from 41, 53, and 53% of the patients examined, respectively [12].
  • Of 7 non-Hodgkin's lymphomas, one case from the oropharynx and 2 from the nasopharynx expressed for the MAGE-1 and MAGE-2 genes, respectively [13].
  • The expression of MAGE-2 and TTF-1 genes was not observed in any of the patients in either the lymphocyte preparations or serum samples [14].

Analytical, diagnostic and therapeutic context of MAGEA2B

  • We therefore analyzed, by means of a reverse transcription-polymerase chain reaction (RT-PCR), the expression of MAGE-1, MAGE-2, and MAGE-3 genes in 60 tissue samples resected from HCCs [15].


  1. The expression of tumor-rejection antigen "MAGE" genes in human gastric carcinoma. Inoue, H., Mori, M., Honda, M., Li, J., Shibuta, K., Mimori, K., Ueo, H., Akiyoshi, T. Gastroenterology (1995) [Pubmed]
  2. Sequence and expression pattern of the human MAGE2 gene. De Smet, C., Lurquin, C., van der Bruggen, P., De Plaen, E., Brasseur, F., Boon, T. Immunogenetics (1994) [Pubmed]
  3. Expression of MAGE-1, MAGE-2 and MAGE-3 genes in human gastric carcinomas; lack of evidence for cytotoxic effects in cases with simultaneous expression of MAGE-3 and HLA-A2. Ofuji, S., Ikeda, M., Tsujitani, S., Ikeguchi, M., Kaibara, N., Yuasa, I., Mitsuya, K., Katoh, M., Ito, H. Anticancer Res. (1998) [Pubmed]
  4. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines. Duan, Z., Duan, Y., Lamendola, D.E., Yusuf, R.Z., Naeem, R., Penson, R.T., Seiden, M.V. Clin. Cancer Res. (2003) [Pubmed]
  5. Molecular cloning and sequencing of feline melanoma antigen 2 (fMAGE-2) obtained from a lymphoma cell line. Ma, Z., Khatlani, T.S., Sasaki, K., Okuda, M., Inokuma, H., Onishi, T. Tissue Antigens (2002) [Pubmed]
  6. HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44. Luescher, I.F., Romero, P., Kuznetsov, D., Rimoldi, D., Coulie, P., Cerottini, J.C., Jongeneel, C.V. J. Biol. Chem. (1996) [Pubmed]
  7. Identification of a MAGE-2-encoded human leukocyte antigen-A24-binding synthetic peptide that induces specific antitumor cytotoxic T lymphocytes. Tahara, K., Takesako, K., Sette, A., Celis, E., Kitano, S., Akiyoshi, T. Clin. Cancer Res. (1999) [Pubmed]
  8. Detection and quantification of CD8(+) T cells specific for HLA-A*0201-binding melanoma and viral peptides by the IFN-gamma-ELISPOT assay. Griffioen, M., Borghi, M., Schrier, P.I., Osanto, S. Int. J. Cancer (2001) [Pubmed]
  9. Identification of HLA-A*0201-restricted CTL epitopes encoded by the tumor-specific MAGE-2 gene product. Visseren, M.J., van der Burg, S.H., van der Voort, E.I., Brandt, R.M., Schrier, P.I., van der Bruggen, P., Boon, T., Melief, C.J., Kast, W.M. Int. J. Cancer (1997) [Pubmed]
  10. Melanoma antigen-encoding gene expression in melanocytic naevi and cutaneous malignant melanomas. Basarab, T., Picard, J.K., Simpson, E., Russell-Jones, R. Br. J. Dermatol. (1999) [Pubmed]
  11. Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma. Sigalotti, L., Coral, S., Nardi, G., Spessotto, A., Cortini, E., Cattarossi, I., Colizzi, F., Altomonte, M., Maio, M. J. Immunother. (2002) [Pubmed]
  12. Expression of MAGE genes in ocular melanoma cell lines. Chen, P.W., Murray, T.G., Salgaller, M.L., Ksander, B.R. J. Immunother. (1997) [Pubmed]
  13. Expression of the MAGE-1, -2, -3, -4, and -6 genes in non-squamous cell carcinoma lesions of the head and neck. Lee, K.D., Eura, M., Ogi, K., Nakano, K., Chikamatsu, K., Masuyama, K., Ishikawa, T. Acta Otolaryngol. (1996) [Pubmed]
  14. Detection of amplifiable messenger RNA in the serum of patients with lung cancer. Fleischhacker, M., Beinert, T., Ermitsch, M., Seferi, D., Possinger, K., Engelmann, C., Jandrig, B. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  15. Expression of MAGE genes and survival in patients with hepatocellular carcinoma. Suzuki, K., Tsujitani, S., Konishi, I., Yamaguchi, Y., Hirooka, Y., Kaibara, N. Int. J. Oncol. (1999) [Pubmed]
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