The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

pColE1_25  -  colicin E1 protein (cea)

Escherichia coli

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cea

  • The data suggest that mitomycin C-induced bidirectional transcription from the cea mRNA and RNA-C promoters is controlled by the SOS regulatory system of Escherichia coli [1].

High impact information on cea

  • We analyzed the structural and functional relationships among independently cloned segments of the plasmid ColE1 region that regulates and codes for colicin E1 (cea), immunity (imm), and the mitomycin C-induced lethality function (lys) [2].
  • Structural and functional organization of the colicin E1 operon [2].
  • Cleavage maps of colicin E1 plasmid DNA and its smaller derivative, pNT1 DNA, were constructed by using restriction endonucleases [3].
  • The site of the nucleotide from which DNA replication is initiated was determined with 6S L-fragments, the DNA fragment first made on colicin E1 plasmid DNA [3].
  • Helix 1 of the membrane-associated closed state of the colicin E1 channel domain was studied by site-directed fluorescence labeling where bimane was covalently attached to a single cysteine residue in each mutant protein [4].

Biological context of cea


Anatomical context of cea


Associations of cea with chemical compounds


Other interactions of cea


Analytical, diagnostic and therapeutic context of cea


  1. Mitomycin C-induced bidirectional transcription from the colicin E1 promoter region in plasmid ColE1. Parker, R.C. Biochim. Biophys. Acta (1986) [Pubmed]
  2. Structural and functional organization of the colicin E1 operon. Waleh, N.S., Johnson, P.H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Origin of replication of colicin E1 plasmid DNA. Tomizawa, J.I., Ohmori, H., Bird, R.E. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  4. Scanning the membrane-bound conformation of helix 1 in the colicin E1 channel domain by site-directed fluorescence labeling. Musse, A.A., Wang, J., Deleon, G.P., Prentice, G.A., London, E., Merrill, A.R. J. Biol. Chem. (2006) [Pubmed]
  5. Regulation of gene expression in plasmid ColE1: delayed expression of the kil gene. Zhang, S.P., Yan, L.F., Zubay, G. J. Bacteriol. (1988) [Pubmed]
  6. The nucleotide sequence surrounding the promoter region of colicin E1 gene. Ebina, Y., Kishi, F., Miki, T., Kagamiyama, H., Nakazawa, T., Nakazawa, A. Gene (1981) [Pubmed]
  7. Overproduction and purification of the colicin E1 immunity protein. Shirabe, K., Yamada, M., Merrill, A.R., Cramer, W.A., Nakazawa, A. Plasmid (1993) [Pubmed]
  8. Plasmid-encoded regulation of colicin E1 gene expression. Ebina, Y., Takahara, Y., Shirabe, K., Yamada, M., Nakazawa, T., Nakazawa, A. J. Bacteriol. (1983) [Pubmed]
  9. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Bolivar, F., Rodriguez, R.L., Greene, P.J., Betlach, M.C., Heyneker, H.L., Boyer, H.W. Gene (1977) [Pubmed]
  10. Differential scanning calorimetric and theoretical studies of ColE1 DNA. Maeda, Y., Ohtsubo, E. Nucleic Acids Symp. Ser. (1986) [Pubmed]
  11. Mobilization of the Escherichia coli plasmid ColE1 (colicin E1) and ColE1 vectors used in recombinant DNA experiments. Dougan, G., Crosa, J.H., Falkow, S. J. Infect. Dis. (1978) [Pubmed]
WikiGenes - Universities