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Gene Review

int  - 

Enterobacteria phage lambda

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Disease relevance of int


High impact information on int


Biological context of int

  • The structures show how the simultaneous binding of two separate domains of lambda-int to DNA facilitates synapsis and can specify the order of DNA strand cleavage and exchange [6].
  • After transduction of each copy, a helper plasmid bearing phage lambda xis and int genes is introduced into the cells to excise the drug resistance gene flanked with the lambda attL and lambda attR sites from the chromosome [7].
  • The DNA sequence of the int and xis genes of lambda bacteriophage, as well as that of the PI promoter and a region of unknown function beyond this, was determined by the chain termination procedure [8].
  • To analyse the mechanism by which rare codons near the initiation codon inhibit cell growth and protein synthesis, we used the bacteriophage lambda int gene or early codon substitution derivatives [9].
  • Removal of a terminator structure by RNA processing regulates int gene expression [10].

Other interactions of int


  1. Characterization of the cryptic lambdoid prophage DLP12 of Escherichia coli and overlap of the DLP12 integrase gene with the tRNA gene argU. Lindsey, D.F., Mullin, D.A., Walker, J.R. J. Bacteriol. (1989) [Pubmed]
  2. The bacteriophage lambda int gene product. A filter assay for genetic recombination, purification of int, and specific binding to DNA. Kikuchi, Y., Nash, H.A. J. Biol. Chem. (1978) [Pubmed]
  3. Regulation of integration by coliphage lambda: activation of int transcription by the cII and cIII proteins. Honigman, A., Hu, S.L., Szybalski, W. Virology (1979) [Pubmed]
  4. Posttranscriptional control of bacteriophage lambda gene expression from a site distal to the gene. Guarneros, G., Montañez, C., Hernandez, T., Court, D. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Bacteriophage lambda int protein recognizes two classes of sequence in the phage att site: characterization of arm-type sites. Ross, W., Landy, A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  6. A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas, T., Aihara, H., Radman-Livaja, M., Filman, D., Landy, A., Ellenberger, T. Nature (2005) [Pubmed]
  7. A method for construction of E. coli strains with multiple DNA insertions in the chromosome. Peredelchuk, M.Y., Bennett, G.N. Gene (1997) [Pubmed]
  8. DNA sequence of the int-xis-Pi region of the bacteriophage lambda; overlap of the int and xis genes. Davies, R.W. Nucleic Acids Res. (1980) [Pubmed]
  9. The pair of arginine codons AGA AGG close to the initiation codon of the lambda int gene inhibits cell growth and protein synthesis by accumulating peptidyl-tRNAArg4. Olivares-Trejo, J.J., Bueno-Martínez, J.G., Guarneros, G., Hernández-Sánchez, J. Mol. Microbiol. (2003) [Pubmed]
  10. Removal of a terminator structure by RNA processing regulates int gene expression. Schmeissner, U., McKenney, K., Rosenberg, M., Court, D. J. Mol. Biol. (1984) [Pubmed]
  11. The cII-independent expression of the phage lambda int gene in RNase III-defective E. coli. Belfort, M. Gene (1980) [Pubmed]
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