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Gene Review

UGDH  -  UDP-glucose 6-dehydrogenase

Bos taurus

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High impact information on UGDH


Anatomical context of UGDH

  • Expression of the enzyme in COS-7 cells showed a 3-fold increase in UDP-glucose dehydrogenase activity; also, the C-terminal 23 amino acids was shown not to be necessary for enzyme activity [4].
  • Cadmium did not increase the breakdown of UDPGA by microsomal UDPGA pyrophosphatase but strongly decreased (30-66%) the synthesis of the cofactor in the cytosol by inhibiting UDP-glucose dehydrogenase (UDPGDH) [5].

Associations of UGDH with chemical compounds


Analytical, diagnostic and therapeutic context of UGDH


  1. Synthesis and characterization of 5-azido-UDP-glucuronic acid. A new photoaffinity probe for UDP-glucuronic acid-utilizing proteins. Drake, R.R., Zimniak, P., Haley, B.E., Lester, R., Elbein, A.D., Radominska, A. J. Biol. Chem. (1991) [Pubmed]
  2. Mechanism of action of uridine diphoglucose dehydrogenase. Evidence for an essential lysine residue at the active site. Ordman, A.B., Kirkwood, S. J. Biol. Chem. (1977) [Pubmed]
  3. Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase. Franzen, B., Carrubba, C., Feingold, D.S., Ashcom, J., Franzen, J.S. Biochem. J. (1981) [Pubmed]
  4. cDNA cloning and expression of UDP-glucose dehydrogenase from bovine kidney. Lind, T., Falk, E., Hjertson, E., Kusche-Gullberg, M., Lidholt, K. Glycobiology (1999) [Pubmed]
  5. Mechanism of cadmium-decreased glucuronidation in the rat. Alary, J., Cravedi, J.P., Baradat, M., Carrera, G. Biochem. Pharmacol. (1992) [Pubmed]
  6. Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP-N-acetylglucosamine pyrophosphorylase. De Luca, C., Lansing, M., Crescenzi, F., Martini, I., Shen, G.J., O'Regan, M., Wong, C.H. Bioorg. Med. Chem. (1996) [Pubmed]
  7. Biosynthesis of glycosaminoglycans: uridine diphosphate glucose 4'-epimerase from cornea and epiphysial-plate cartilage. De Luca, G., Speziale, P., Balduini, C., Castellani, A.A. Connect. Tissue Res. (1975) [Pubmed]
  8. Purification of UDP-glucose dehydrogenase by hydrophobic and affinity chromatography. Geren, C.R., Olomon, C.M., Primrose, D.C., Ebner, K.E. Prep. Biochem. (1977) [Pubmed]
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