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Gene Review

SYNJ1  -  synaptojanin 1

Bos taurus

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High impact information on SYNJ1


Biological context of SYNJ1


Anatomical context of SYNJ1

  • All these results suggest that Ash may function as a regulator of synaptic vesicle transport through dynamin, p150 and p65 [2].
  • Immunohistochemical staining of rat brain showed p150 and p65 to be localized in a variety of neurons in the cerebellum and hippocampus, with p65 being especially concentrated in the nerve terminal [2].
  • By immunoelectron microscopy p150 was subsequently transiently detectable on the sporozoite surface and in the lymphocyte cytosol [3].

Analytical, diagnostic and therapeutic context of SYNJ1

  • It was found that p150 and p65 are expressed predominantly in brain, although Ash is widely distributed in all tissues examined by Western blots [2].
  • Immunoblotting showed that p150 is also expressed by the schizont stage, but at much lower levels compared to the sporozoite [3].


  1. Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Sakisaka, T., Itoh, T., Miura, K., Takenawa, T. Mol. Cell. Biol. (1997) [Pubmed]
  2. Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65. Miura, K., Miki, H., Shimazaki, K., Kawai, N., Takenawa, T. Biochem. J. (1996) [Pubmed]
  3. Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM). Skilton, R.A., Bishop, R.P., Wells, C.W., Spooner, P.R., Gobright, E., Nkonge, C., Musoke, A.J., Macklin, M., Iams, K.P. Parasitology (1998) [Pubmed]
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