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Gene Review

NPBWR2  -  neuropeptides B/W receptor 2

Homo sapiens

Synonyms: G-protein coupled receptor 8, GPR8, Neuropeptides B/W receptor type 2
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Disease relevance of NPBWR2

  • We demonstrate that, similar to CCR5, the two selected GPCRs from group 1 were capable of mediating M-tropic HIV-1 entry, whereas GPR8 from group 2 did not serve as HIV-1 coreceptor [1].

High impact information on NPBWR2

  • It binds and activates human GPR7 or GPR8 with median effective concentrations (EC(50)) of 0.23 nM and 15.8 nM, respectively [2].
  • We purified the peptide ligand from porcine hypothalamus using stable Chinese hamster ovary cell lines expressing human GPR8 and cloned the cDNA encoding its precursor protein [3].
  • These findings indicate that neuropeptide W is the endogenous ligand for both GPR7 and GPR8 and acts as a mediator of the central control of feeding and the neuroendocrine system [3].
  • NPB and NPW also bound to a second related orphan receptor, GPR8, now designated as NPBW(2) that is present in humans but not rats or mice [4].
  • The absence of a GPR8 gene in the rodent suggests that GPR8 originated from gene duplication of GPR7 after the rodent line diverged from the rabbit, tree shrew, flying lemur, lemur, monkey and human lines [5].

Biological context of NPBWR2


Anatomical context of NPBWR2


Other interactions of NPBWR2

  • Reverse transcription-polymerase chain reaction detected the expression of NPB, NPW, GPR7-R and GPR8-like-R mRNAs in rat adrenocortical cells (both freshly-dispersed and 4-day-cultured cells) [8].
  • Two related G protein-coupled receptors: the distribution of GPR7 in rat brain and the absence of GPR8 in rodents [5].

Analytical, diagnostic and therapeutic context of NPBWR2

  • 3. Northern blot analysis using human mRNA demonstrated expression of GPR7 mainly in cerebellum and frontal cortex, while GPR8 was located mainly in the frontal cortex [6].
  • Using these primers, orthologs of GPR7 and GPR8 were isolated by the PCR from rabbit, tree shrew, and flying lemur, as well as GPR7 in the rat [5].


  1. Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. Efremov, R., Truong, M.J., Darcissac, E.C., Zeng, J., Grau, O., Vergoten, G., Debard, C., Capron, A., Bahr, G.M. Eur. J. Biochem. (1999) [Pubmed]
  2. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S.C., Richardson, J.A., Tsujino, N., Garry, M.G., Lerner, M.R., King, D.S., O'Dowd, B.F., Sakurai, T., Yanagisawa, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. Shimomura, Y., Harada, M., Goto, M., Sugo, T., Matsumoto, Y., Abe, M., Watanabe, T., Asami, T., Kitada, C., Mori, M., Onda, H., Fujino, M. J. Biol. Chem. (2002) [Pubmed]
  4. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Singh, G., Davenport, A.P. Br. J. Pharmacol. (2006) [Pubmed]
  5. Two related G protein-coupled receptors: the distribution of GPR7 in rat brain and the absence of GPR8 in rodents. Lee, D.K., Nguyen, T., Porter, C.A., Cheng, R., George, S.R., O'Dowd, B.F. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  6. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. O'Dowd, B.F., Scheideler, M.A., Nguyen, T., Cheng, R., Rasmussen, J.S., Marchese, A., Zastawny, R., Heng, H.H., Tsui, L.C., Shi, X. Genomics (1995) [Pubmed]
  7. Neuropeptide W exerts a potent suppressive effect on blood leptin and insulin concentrations in the rat. Rucinski, M., Nowak, K.W., Chmielewska, J., Ziolkowska, A., Malendowicz, L.K. Int. J. Mol. Med. (2007) [Pubmed]
  8. Effects of neuropeptides B and W on the secretion and growth of rat adrenocortical cells. Hochol, A., Albertin, G., Nussdorfer, G.G., Spinazzi, R., Ziolkowska, A., Rucinski, M., Malendowicz, L.K. Int. J. Mol. Med. (2004) [Pubmed]
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