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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Lemur


Psychiatry related information on Lemur


High impact information on Lemur

  • For this purpose, approximately 2,400 bp of mitochondrial DNA (part of the COIII gene; ND3, ND4L, and ND4 genes; and five tRNAs) were sequenced in a total of 131 lemurs from 5 families, 12 genera, 25 species, and 18 subspecies to reconstruct phylogenetic relationships among them [3].
  • Similar patterns of PrP immunoreactivity were seen in two symptomatic and 18 apparently healthy lemurs in three different French primate centers, all of which had been fed diets supplemented with a beef protein product manufactured by a British company that has since ceased to include beef in its veterinary nutritional products [4].
  • DNA sequence data for the complete cytochrome b gene, combined with an expanded morphological data set, confirm the results of a previous study and again indicate that all extant Malagasy lemurs originated from a single common ancestor [5].
  • We report herein that M6P/IGF2R is imprinted in Artiodactyla, as it is in Rodentia and Marsupialia, but that it is not imprinted in Scandentia, Dermoptera and Primates, including ringtail lemurs and humans [6].
  • We have isolated the prosimian lemur homologues for STS and SRY [7].

Biological context of Lemur


Anatomical context of Lemur

  • The results point to a widespread distribution of Growth Hormone Secretagogue-Receptor mRNA in the hypothalamus, hippocampal formation, and cerebellar cortex of both lemurs and rats [13].
  • The forebrain and pituitary sites of synthesis of growth hormone secretagogue-receptor mRNA were identified in four adult lemurs (Microcebus murinus) by in situ hybridisation performed with a radiolabeled cRNA probe transcribed from human Growth Hormone Secretagogue-Receptor cDNA [13].

Associations of Lemur with chemical compounds

  • In Lemur catta, for example, all DRB genes have apparently been lost and their function taken over by DOB and/or DPB genes [14].
  • Diurnal variations of plasma testosterone in two prosimian primates (Galago crassicaudatus crassicaudatus and Lemur catta) [15].
  • We conclude that female dominance in ring-tailed lemurs is neither based on physical superiority nor on high androgen levels and that it is equally important to study male subordination and prenatal brain priming effects for a complete understanding of this phenomenon [2].
  • Radioimmunoassay for luteinizing hormone (LH) in the ring-tailed lemur (Lemur catta) with antiovine LH and ovine 125I-LH [16].
  • There is no molar use wear evidence that any of the extinct lemurs relied on terrestrial foods (C4 grasses, tubers, rhizomes) [17].

Gene context of Lemur


Analytical, diagnostic and therapeutic context of Lemur

  • All three injectable medetomidine combinations were effective in ring-tailed lemurs but only MBK and MBMz provided adequate depth and duration of anesthesia for use as sole regimes [21].
  • Complete health assessments were performed on 20 adult ring-tailed lemurs (Lemur catta), 10 males and 10 females, free ranging within the Tsimanampetsotsa Strict Nature Reserve in southwest Madagascar. Each animal was anesthetized using tiletamine and zolazepam, weighed, and given a thorough physical examination [22].
  • A 6-mo study in ring-tailed lemurs (Lemur catta) and collared lemurs (Eulemur fulvus collaris) and two studies in baboons (Papio cynocephalus) (7.5 wks and 6.5 mo) tested the benefits of a primate diet coated with 0.6% sodium hexametaphosphate (HMP) in controlling calculus in these species using a sequential crossover design [23].


  1. Naturally occurring Ehrlichia chaffeensis infection in two prosimian primate species: ring-tailed lemurs (Lemur catta) and ruffed lemurs (Varecia variegata). Williams, C.V., Van Steenhouse, J.L., Bradley, J.M., Hancock, S.I., Hegarty, B.C., Breitschwerdt, E.B. Emerging Infect. Dis. (2002) [Pubmed]
  2. Androgen levels and female social dominance in Lemur catta. von Engelhardt, N., Kappeler, P.M., Heistermann, M. Proc. Biol. Sci. (2000) [Pubmed]
  3. A molecular approach to comparative phylogeography of extant Malagasy lemurs. Pastorini, J., Thalmann, U., Martin, R.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents. Bons, N., Mestre-Frances, N., Belli, P., Cathala, F., Gajdusek, D.C., Brown, P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Ancient single origin for Malagasy primates. Yoder, A.D., Cartmill, M., Ruvolo, M., Smith, K., Vilgalys, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Killian, J.K., Nolan, C.M., Wylie, A.A., Li, T., Vu, T.H., Hoffman, A.R., Jirtle, R.L. Hum. Mol. Genet. (2001) [Pubmed]
  7. Transposition of SRY into the ancestral pseudoautosomal region creates a new pseudoautosomal boundary in a progenitor of simian primates. Gläser, B., Myrtek, D., Rumpler, Y., Schiebel, K., Hauwy, M., Rappold, G.A., Schempp, W. Hum. Mol. Genet. (1999) [Pubmed]
  8. Isolation and sequence analysis of a hybrid delta-globin pseudogene from the brown lemur. Jeffreys, A.J., Barrie, P.A., Harris, S., Fawcett, D.H., Nugent, Z.J., Boyd, A.C. J. Mol. Biol. (1982) [Pubmed]
  9. Nucleotide sequence analysis of the lemur beta-globin gene family: evidence for major rate fluctuations in globin polypeptide evolution. Harris, S., Thackeray, J.R., Jeffreys, A.J., Weiss, M.L. Mol. Biol. Evol. (1986) [Pubmed]
  10. Confirmation, via in situ hybridization, of the occurrence of Robertsonian translocations during lemur evolution by localization of GLUDP1 DNA sequences on lemur chromosomes. Jung, K.Y., Warter, S., Rumpler, Y. Cytogenet. Cell Genet. (1991) [Pubmed]
  11. Corticotropin-releasing hormone-binding protein in primates. Bowman, M.E., Lopata, A., Jaffe, R.B., Golos, T.G., Wickings, J., Smith, R. Am. J. Primatol. (2001) [Pubmed]
  12. Demonstration of homoeologies between human and lemur chromosomes by chromosome painting. Apiou, F., Rumpler, Y., Warter, S., Vezuli, A., Dutrillaux, B. Cytogenet. Cell Genet. (1996) [Pubmed]
  13. Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. Mitchell, V., Bouret, S., Beauvillain, J.C., Schilling, A., Perret, M., Kordon, C., Epelbaum, J. J. Comp. Neurol. (2001) [Pubmed]
  14. The origin of the primate Mhc-DRB genes and allelic lineages as deduced from the study of prosimians. Figueroa, F., O'hUigin, C., Tichy, H., Klein, J. J. Immunol. (1994) [Pubmed]
  15. Diurnal variations of plasma testosterone in two prosimian primates (Galago crassicaudatus crassicaudatus and Lemur catta). Van Horn, R.N., Beamer, N.B., Dixson, A.F. Biol. Reprod. (1976) [Pubmed]
  16. Radioimmunoassay for luteinizing hormone (LH) in the ring-tailed lemur (Lemur catta) with antiovine LH and ovine 125I-LH. Norman, R.L., Brandt, H., van Horn, R.N. Biol. Reprod. (1978) [Pubmed]
  17. Dental use wear in extinct lemurs: evidence of diet and niche differentiation. Godfrey, L.R., Semprebon, G.M., Jungers, W.L., Sutherland, M.R., Simons, E.L., Solounias, N. J. Hum. Evol. (2004) [Pubmed]
  18. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. Masquilier, D., Foulkes, N.S., Mattei, M.G., Sassone-Corsi, P. Cell Growth Differ. (1993) [Pubmed]
  19. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Charchar, F.J., Svartman, M., El-Mogharbel, N., Ventura, M., Kirby, P., Matarazzo, M.R., Ciccodicola, A., Rocchi, M., D'Esposito, M., Graves, J.A. Genome Res. (2003) [Pubmed]
  20. Birth of a gene: locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage. Kuryshev, V.Y., Skryabin, B.V., Kremerskothen, J., Jurka, J., Brosius, J. J. Mol. Biol. (2001) [Pubmed]
  21. Comparison of the efficacy and cardiorespiratory effects of medetomidine-based anesthetic protocols in ring-tailed lemurs (Lemur catta). Williams, C.V., Glenn, K.M., Levine, J.F., Horne, W.A. J. Zoo Wildl. Med. (2003) [Pubmed]
  22. Biomedical evaluation of free-ranging ring-tailed lemurs (Lemur catta) in Tsimanampetsotsa Strict Nature Reserve, Madagascar. Dutton, C.J., Junge, R.E., Louis, E.E. J. Zoo Wildl. Med. (2003) [Pubmed]
  23. Preventing dental calculus formation in lemurs (Lemur catta, Eulemur fulvus collaris) and baboons (Papio cynocephalus). Willis, G.P., Kapustin, N., Warrick, J.M., Miller, L.L., Stookey, G.K., Hopkins, D.T., Doan, E.J., Ross, S.R. J. Zoo Wildl. Med. (1999) [Pubmed]
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