High impact information on Sox10

• However, this activity requires a higher Sox10 gene dosage than does the maintenance of neurogenic potential [1].
• Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells [2].
• Interestingly, Sox10 also modulated the function of Pax3 and Krox-20, two other transcription factors involved in Schwann cell development [3].
• During development Sox10 first appeared in the forming neural crest and continued to be expressed as these cells contributed to the forming PNS and finally differentiated into Schwann cells [3].
• Sox10, a novel transcriptional modulator in glial cells [3].

Biological context of Sox10

• Instead, Sox10 functioned synergistically with the POU domain protein Tst-1/Oct6/SCIP with which it is coexpressed during certain stages of Schwann cell development [3].
• Here we show that Sox10 functions through two different types of DNA response elements, one that allows binding of monomers, and a second that favors cooperative binding of two molecules [4].
• This dimeric binding required the presence of two heptameric Sox binding sites in a specific orientation and spacing, and was mediated by an N-terminal region of Sox10 with high conservation in the related Sox9, which also exhibited dimeric binding [4].

Anatomical context of Sox10

• In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain [3].

Associations of Sox10 with chemical compounds

• The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences [4].

References