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Gene Review

Sox10  -  SRY (sex determining region Y)-box 10

Rattus norvegicus

Synonyms: Transcription factor SOX-10
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High impact information on Sox10


Biological context of Sox10

  • Instead, Sox10 functioned synergistically with the POU domain protein Tst-1/Oct6/SCIP with which it is coexpressed during certain stages of Schwann cell development [3].
  • Here we show that Sox10 functions through two different types of DNA response elements, one that allows binding of monomers, and a second that favors cooperative binding of two molecules [4].
  • This dimeric binding required the presence of two heptameric Sox binding sites in a specific orientation and spacing, and was mediated by an N-terminal region of Sox10 with high conservation in the related Sox9, which also exhibited dimeric binding [4].

Anatomical context of Sox10

  • In the CNS, Sox10 transcripts were originally confined to glial precursors and later detected in oligodendrocytes of the adult brain [3].

Associations of Sox10 with chemical compounds


  1. SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Kim, J., Lo, L., Dormand, E., Anderson, D.J. Neuron (2003) [Pubmed]
  2. Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. Ito, Y., Wiese, S., Funk, N., Chittka, A., Rossoll, W., Bömmel, H., Watabe, K., Wegner, M., Sendtner, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Sox10, a novel transcriptional modulator in glial cells. Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., Wegner, M. J. Neurosci. (1998) [Pubmed]
  4. The glial transcription factor Sox10 binds to DNA both as monomer and dimer with different functional consequences. Peirano, R.I., Wegner, M. Nucleic Acids Res. (2000) [Pubmed]
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