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Gene Review:

CeHV15gLMP1 - LMP1

Macacine herpesvirus 4

Du, C. et al., Mainou, B.A. et al., Saechan, V. et al., Huang, S. et al., László, L. et al., et al.

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Disease relevance of CeHV15gLMP1

Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1 [1].

High impact information on CeHV15gLMP1

Among the nine different EBV proteins expressed in latently infected B cells (nuclear and plasma membrane-associated), only LMP1, LMP2A and EBNA2 were shown to selectively transactivate the alpha(v) integrin promoter [2].
Latent membrane protein 1 (LMP1) is considered the EBV oncogene as it is necessary for EBV-induced transformation of B lymphocytes and is able to transform Rat-1 fibroblasts [3].
All of the LMP1 variants transformed Rat-1 fibroblasts, induced increased motility of HFK cells, and induced increased homotypic adhesion of BJAB cells [3].
Immunogold electron microscopy shows that LMP-1 is primarily concentrated in secondary lysosomes together with ubiquitin-protein conjugates and heat-shock protein 70 [4].
Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity [5].

Biological context of CeHV15gLMP1

Most importantly, the S215 phosphorylation was also detected in F-LMP1-expressing human cell lines [6].
Certain EBV strains defined by their LMP1 sequence may influence cell tropism, disease association, or disease severity [5].
This dose of As2O3 significantly induced apoptosis and growth retardation of HNE1-LMP1 cells [7].
Recombinant LMP1 induced a strong inhibition of T-cell proliferation (IC50 = 0.17 nM) [8].
CONCLUSION: Arsenic trioxide can inhibit LMP1 expression and dictate apoptosis and alterations of cell cycle distribution as well as growth retardation [7].

Anatomical context of CeHV15gLMP1

In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation [9].

Analytical, diagnostic and therapeutic context of CeHV15gLMP1

The LMP1 protein expression and mRNA level in HNE1-LMP1 cells were determined by western blot, confocal immunofluorescence staining and semiquantitative reverse transcriptase reaction (RT-PCR) [7].

References

Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1. Franken, M., Devergne, O., Rosenzweig, M., Annis, B., Kieff, E., Wang, F. J. Virol. (1996) [Pubmed]
Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of alpha(v) integrins. Huang, S., Stupack, D., Liu, A., Cheresh, D., Nemerow, G.R. Oncogene (2000) [Pubmed]
LMP1 strain variants: biological and molecular properties. Mainou, B.A., Raab-Traub, N. J. Virol. (2006) [Pubmed]
The latent membrane protein-1 in Epstein-Barr virus-transformed lymphoblastoid cells is found with ubiquitin-protein conjugates and heat-shock protein 70 in lysosomes oriented around the microtubule organizing centre. László, L., Tuckwell, J., Self, T., Lowe, J., Landon, M., Smith, S., Hawthorne, J.N., Mayer, R.J. J. Pathol. (1991) [Pubmed]
Analysis of LMP1 variants of EBV in Southern Thailand: evidence for strain-associated T-cell tropism and pathogenicity. Saechan, V., Mori, A., Mitarnun, W., Settheetham-Ishida, W., Ishida, T. J. Clin. Virol. (2006) [Pubmed]
Identification of a new in vivo phosphorylation site in the cytoplasmic carboxyl terminus of EBV-LMP1 by tandem mass spectrometry. Chien, K.Y., Chang, Y.S., Yu, J.S., Fan, L.W., Lee, C.W., Chi, L.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Downregulation of Epstein-Barr virus-encoded latent membrane protein-1 by arsenic trioxide in nasopharyngeal carcinoma cells. Du, C., Wen, B., Li, D., Lin, Y., Zheng, Y., Peng, X., Hong, C., Chen, J., Lin, W., Hong, X., Xie, L., Wu, M. Tumori. (2006) [Pubmed]
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9. Keryer-Bibens, C., Pioche-Durieu, C., Villemant, C., Souquère, S., Nishi, N., Hirashima, M., Middeldorp, J., Busson, P. BMC Cancer (2006) [Pubmed]
In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Bollard, C.M., Gottschalk, S., Huls, M.H., Molldrem, J., Przepiorka, D., Rooney, C.M., Heslop, H.E. Leuk. Lymphoma (2006) [Pubmed]

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