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Gene Review

gdf8  -  growth differentiation factor 8

Danio rerio

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High impact information on gdf8


Biological context of gdf8


Anatomical context of gdf8

  • Although only the precursor protein form was revealed in the adult lateral muscle, we demonstrated that zebrafish myostatin is proteolytically processed and secreted in cultured cells, as is its mammalian counterpart [6].

Analytical, diagnostic and therapeutic context of gdf8


  1. Phylogenetic analysis of the myostatin gene sub-family and the differential expression of a novel member in zebrafish. Kerr, T., Roalson, E.H., Rodgers, B.D. Evol. Dev. (2005) [Pubmed]
  2. Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Lee, C.Y., Ko, Y.L., Lu, J.K., Her, G.M., Chen, T.T., Wu, J.L. Dev. Dyn. (2004) [Pubmed]
  3. Homologous recombination in zebrafish ES cells. Fan, L., Moon, J., Crodian, J., Collodi, P. Transgenic Res. (2006) [Pubmed]
  4. Myostatin precursor is present in several tissues in teleost fish: a comparative immunolocalization study. Radaelli, G., Rowlerson, A., Mascarello, F., Patruno, M., Funkenstein, B. Cell Tissue Res. (2003) [Pubmed]
  5. Analysis of myostatin gene structure, expression and function in zebrafish. Xu, C., Wu, G., Zohar, Y., Du, S.J. J. Exp. Biol. (2003) [Pubmed]
  6. Myostatin expression during development and chronic stress in zebrafish (Danio rerio). Vianello, S., Brazzoduro, L., Dalla Valle, L., Belvedere, P., Colombo, L. J. Endocrinol. (2003) [Pubmed]
  7. Myostatin gene silenced by RNAi show a zebrafish giant phenotype. Acosta, J., Carpio, Y., Borroto, I., González, O., Estrada, M.P. J. Biotechnol. (2005) [Pubmed]
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