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Gene Review

eIF4E-7  -  CG32859 gene product from transcript...

Drosophila melanogaster

Synonyms: CG11392, CG11393, CG32859, CT31794, Dmel\CG32859, ...
 
 
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Disease relevance of eIF4E-7

 

High impact information on eIF4E-7

  • Thus, d4E-BP is an important downstream effector of a dFOXO phenotype, and regulation of translation by eIF4E is vital during environmental stress [3].
  • Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP [3].
  • We furthermore show that cup and eIF4E interact genetically, because a reduction in the level of eIF4E activity deteriorates the development and growth of ovaries bearing homozygous cup mutant alleles [4].
  • Cup is required for the correct accumulation and localization of eIF4E within the posterior cytoplasm of developing oocytes [4].
  • We generated lk6 loss-of-function alleles and found that eIF4E phosphorylation is dramatically reduced in lk6 mutants [5].
 

Biological context of eIF4E-7

 

Associations of eIF4E-7 with chemical compounds

  • To overcome this protective mechanism, we introduced alanine substitutions at four phosphorylation/inactivation sites in 4EBP1 to constitutively activate a 4EBP mu to block eIF4E [9].

References

  1. Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Bernal, A., Kimbrell, D.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Structural analysis of the eukaryotic initiation factor 4E gene controlling potyvirus resistance in pepper: exploitation of a BAC library. Ruffel, S., Caranta, C., Palloix, A., Lefebvre, V., Caboche, M., Bendahmane, A. Gene (2004) [Pubmed]
  3. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N., Lasko, P.F. Genes Dev. (2005) [Pubmed]
  4. Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development. Zappavigna, V., Piccioni, F., Villaescusa, J.C., Verrotti, A.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development. Arquier, N., Bourouis, M., Colombani, J., Léopold, P. Curr. Biol. (2005) [Pubmed]
  6. Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. Hernández, G., Vázquez-Pianzola, P., Sierra, J.M., Rivera-Pomar, R. RNA (2004) [Pubmed]
  7. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. Lavoie, C.A., Lachance, P.E., Sonenberg, N., Lasko, P. J. Biol. Chem. (1996) [Pubmed]
  8. Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis. Nakamura, A., Sato, K., Hanyu-Nakamura, K. Dev. Cell (2004) [Pubmed]
  9. Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth. Lynch, M., Fitzgerald, C., Johnston, K.A., Wang, S., Schmidt, E.V. J. Biol. Chem. (2004) [Pubmed]
 
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