Gene Review:
Thor - CG8846 gene product from transcript CG8846-RA
Drosophila melanogaster
Synonyms:
153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, ...
- Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Bernal, A., Kimbrell, D.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback. Marr, M.T., D'Alessio, J.A., Puig, O., Tjian, R. Genes Dev. (2007)
- 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Teleman, A.A., Chen, Y.W., Cohen, S.M. Genes Dev. (2005)
- Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Tettweiler, G., Miron, M., Jenkins, M., Sonenberg, N., Lasko, P.F. Genes Dev. (2005)
- Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Miron, M., Lasko, P., Sonenberg, N. Mol. Cell. Biol. (2003)
- The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Miron, M., Verdú, J., Lachance, P.E., Birnbaum, M.J., Lasko, P.F., Sonenberg, N. Nat. Cell Biol. (2001)
- Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth. Lynch, M., Fitzgerald, C., Johnston, K.A., Wang, S., Schmidt, E.V. J. Biol. Chem. (2004)
- Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Puig, O., Marr, M.T., Ruhf, M.L., Tjian, R. Genes Dev. (2003)
- The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. Jünger, M.A., Rintelen, F., Stocker, H., Wasserman, J.D., Végh, M., Radimerski, T., Greenberg, M.E., Hafen, E. J. Biol. (2003)