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Gene Review

EIF4E  -  eukaryotic translation initiation factor 4E

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High impact information on EIF4E

  • In BAEC, TNF promotes phosphorylation of eukaryotic initiation factor 4E (eIF-4E), c-Jun N-terminal kinase (JNK) and ceramide-activated protein kinase activities, Jun-b expression, prostacyclin production, and, when protein synthesis is inhibited, cytotoxicity [1].
  • Bovine kidney eIF-4E enhanced up to 1.8-fold globin synthesis in m7GTP-Sepharose-treated reticulocyte lysates [2].
  • We present evidence that a specific repressor of eIF4E, the binding protein 4E-BP1, is present and could be involved in preventing eIF4E function in metaphase II stage oocytes [3].
  • Regulation of translation during in vitro maturation of bovine oocytes: the role of MAP kinase, eIF4E (cap binding protein) phosphorylation, and eIF4E-BP1 [3].
  • The inability of Hsc70 to fully protect protein synthesis from inhibition induced by heat shock or GSSG was due to inability of Hsc70 to protect eIF-4 E from heat-induced dephosphorylation, and its inability to protect translational elongation from GSSG-induced inhibition, respectively [4].

Biological context of EIF4E

  • The eIF-4E mRNA level was significantly higher in the lactating mammary gland compared to the mammary tissues obtained from heifers during the third estrous cycle [5].
  • Elevated eIF-4E expression during lactation may be related to increased translation of certain mRNA or the acceleration of overall protein synthesis [5].
  • The results suggest that cPK could contribute to the insulin-stimulated phosphorylation of eIF-4E, but that protein phosphatase 2A may confer the site specificity of this response [2].
  • We show that during meiotic maturation of bovine oocytes, the translation initiation factor, eIF4E (the cap binding protein), gradually becomes phosphorylated [3].
  • However, although eIF4E is nearly fully phosphorylated in metaphase II oocytes, protein synthesis reaches only basal levels at this stage, similar to that of prophase I oocytes, in which the factor remains unphosphorylated [3].

Anatomical context of EIF4E


Associations of EIF4E with chemical compounds


Regulatory relationships of EIF4E


Other interactions of EIF4E

  • By contrast, purified preparations of two forms of mitogen-activated protein kinase, casein kinase II and two forms of a distinct autophosphorylation-activated protein kinase exhibited little activity, if any, with eIF-4E [6].

Analytical, diagnostic and therapeutic context of EIF4E


  1. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine. Marino, M.W., Dunbar, J.D., Wu, L.W., Ngaiza, J.R., Han, H.M., Guo, D., Matsushita, M., Nairn, A.C., Zhang, Y., Kolesnick, R., Jaffe, E.A., Donner, D.B. J. Biol. Chem. (1996) [Pubmed]
  2. Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase. Makkinje, A., Xiong, H., Li, M., Damuni, Z. J. Biol. Chem. (1995) [Pubmed]
  3. Regulation of translation during in vitro maturation of bovine oocytes: the role of MAP kinase, eIF4E (cap binding protein) phosphorylation, and eIF4E-BP1. Tomek, W., Melo Sterza, F.A., Kubelka, M., Wollenhaupt, K., Torner, H., Anger, M., Kanitz, W. Biol. Reprod. (2002) [Pubmed]
  4. Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate. Thulasiraman, V., Xu, Z., Uma, S., Gu, Y., Chen, J.J., Matts, R.L. Eur. J. Biochem. (1998) [Pubmed]
  5. Cloning of bovine eukaryotic translation initiation factor 4E (eIF-4E) and its expression in the bovine mammary gland at different physiological stages. Long, E., Capuco, A.V., Zhao, X. DNA Seq. (2001) [Pubmed]
  6. Protamine kinase phosphorylates eukaryotic protein synthesis initiation factor 4E. Amick, G.D., Damuni, Z. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
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